Steven Shaw
@steven-shaw.bsky.social
Postdoctoral Researcher at the University of Bristol examining Anti-phage systems in the Szczelkun Lab| Biochemical, Biophysical and Nanopore
Exciting PhD opportunity! Uncover the molecular mechanism of the MADS bacterial immune system and its synergy with CRISPR-Cas. Based in the Szczelkun lab in Bristol with strong collaboration with the Blower lab at NEB and opportunities to work with other amazing research groups! Link below:
November 8, 2025 at 5:48 PM
Exciting PhD opportunity! Uncover the molecular mechanism of the MADS bacterial immune system and its synergy with CRISPR-Cas. Based in the Szczelkun lab in Bristol with strong collaboration with the Blower lab at NEB and opportunities to work with other amazing research groups! Link below:
New preprint!
Using single-molecule and kinetic assays combined with nanopore, myself, @alex-hg.bsky.social, @oscart32.bsky.social & co showed that the SauUSI restriction enzyme from S. aureus recognizes methylated DNA and initiates a motor-driven shredding process.
www.biorxiv.org/cgi/content/...
Using single-molecule and kinetic assays combined with nanopore, myself, @alex-hg.bsky.social, @oscart32.bsky.social & co showed that the SauUSI restriction enzyme from S. aureus recognizes methylated DNA and initiates a motor-driven shredding process.
www.biorxiv.org/cgi/content/...
October 20, 2025 at 8:53 AM
New preprint!
Using single-molecule and kinetic assays combined with nanopore, myself, @alex-hg.bsky.social, @oscart32.bsky.social & co showed that the SauUSI restriction enzyme from S. aureus recognizes methylated DNA and initiates a motor-driven shredding process.
www.biorxiv.org/cgi/content/...
Using single-molecule and kinetic assays combined with nanopore, myself, @alex-hg.bsky.social, @oscart32.bsky.social & co showed that the SauUSI restriction enzyme from S. aureus recognizes methylated DNA and initiates a motor-driven shredding process.
www.biorxiv.org/cgi/content/...
Reposted by Steven Shaw
Happy that the final version of our Lamassu work @yli18smc.bsky.social is now out:
www.nature.com/articles/s41...
Thanks again to our awesome collaborators @mblokesch.bsky.social and David and co and Mark Szczelkun and @steven-shaw.bsky.social and the DCI Lausanne @fbm-unil.bsky.social
www.nature.com/articles/s41...
Thanks again to our awesome collaborators @mblokesch.bsky.social and David and co and Mark Szczelkun and @steven-shaw.bsky.social and the DCI Lausanne @fbm-unil.bsky.social
Glad to share the work of @yli18smc.bsky.social and co on Lamassu, a bacterial defense system related to Rad50/Mre11 (RM). While RM carefully trims DNA ends for repair, Lamassu chops up the host chromosome. Our study reveals how it is regulated to minimize damage, activating only during infection.
October 14, 2025 at 9:28 AM
Happy that the final version of our Lamassu work @yli18smc.bsky.social is now out:
www.nature.com/articles/s41...
Thanks again to our awesome collaborators @mblokesch.bsky.social and David and co and Mark Szczelkun and @steven-shaw.bsky.social and the DCI Lausanne @fbm-unil.bsky.social
www.nature.com/articles/s41...
Thanks again to our awesome collaborators @mblokesch.bsky.social and David and co and Mark Szczelkun and @steven-shaw.bsky.social and the DCI Lausanne @fbm-unil.bsky.social
Reposted by Steven Shaw
Glad to share the work of @yli18smc.bsky.social and co on Lamassu, a bacterial defense system related to Rad50/Mre11 (RM). While RM carefully trims DNA ends for repair, Lamassu chops up the host chromosome. Our study reveals how it is regulated to minimize damage, activating only during infection.
March 16, 2025 at 9:15 AM
Glad to share the work of @yli18smc.bsky.social and co on Lamassu, a bacterial defense system related to Rad50/Mre11 (RM). While RM carefully trims DNA ends for repair, Lamassu chops up the host chromosome. Our study reveals how it is regulated to minimize damage, activating only during infection.