Stijn Nuiten
@stijnnuiten.bsky.social
140 followers 200 following 6 posts
Postdoctoral researcher at the Translational Psychiatry Lab, University of Basel & UPK Basel. Interested in the role of neuromodulatory systems and arousal on perception in health and disease.
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Reposted by Stijn Nuiten
n41c0.bsky.social
To celebrate the defence of my PhD, and thanks to
@ibbamsterdam.bsky.social, I will host a symposium titled "Vision as prediction: learning, action, and biases" on June 6. Program, registration and more information here: bit.ly/43reOgR
stijnnuiten.bsky.social
Neural and computational analyses further revealed that task effects on preparatory activity over motor cortex, resembling a starting point bias, were smallest on trials with high phasic pupil-linked arousal. (5/6)
Bias manipulation modulates pre-stimulus motor cortex lateralisation, reflecting a starting point bias. This task-related modulation of lateralised activity is weakest on trials with large phasic pupil-linked arousal.
stijnnuiten.bsky.social
Where increased tonic arousal (pupil-linked; trend for drugs) was related to more liberal ('yes') decisions independent of task, increased phasic arousal was uniquely associated with weaker task-related shifts in decision bias. Tonic & phasic arousal thus distinctly shaped decision bias. (4/6)
Tonic and phasic pupil-linked arousal distinctly related to human decision bias. Where increased tonic pupil-linked arousal is related to more liberal decision-making across experimental conditions, increased phasic pupil-linked arousal specifically relates to a minimisation of task-related bias.
stijnnuiten.bsky.social
Here, we aimed to 1) uncover the neural mechanisms by which arousal governs decision bias and 2) causally test if/how tonic arousal affects bias. To do so, we combined correlational measures (pupillometry) & causal manipulations (pharmacology) of arousal with EEG and two bias-inducing tasks. (3/6)
stijnnuiten.bsky.social
Earlier work from our group revealed profound behavioral arousal effects: e.g. elevated tonic arousal improves centroparietal sensory evidence accumulation but impairs prefrontal metacognitive processes (doi.org/10.1523/ENEU...), while phasic arousal modulates bias (De Gee et al, eLife, 2017). (2/6)
Pharmacological Elevation of Catecholamine Levels Improves Perceptual Decisions, But Not Metacognitive Insight
Perceptual decisions are often accompanied by a feeling of decision confidence. Where the parietal cortex is known for its crucial role in shaping such perceptual decisions, metacognitive evaluations ...
doi.org