@subletterdave.bsky.social
Our new pre-print is out! The result of a wonderful collaboration with the Tanaka lab at RIKEN Center for Brain Science.
We investigate the question: what can yeast prions teach us about the connection between amyloid polymorphism and phenotype?
www.researchsquare.com/article/rs-7...
We investigate the question: what can yeast prions teach us about the connection between amyloid polymorphism and phenotype?
www.researchsquare.com/article/rs-7...
How Sup35 monomer conformation and amyloid fibril polymorphism determine yeast strain phenotypes
In the [PSI+] prion system, the yeast prion protein Sup35 can form structurally distinct amyloid fibrils that lead to distinct transmissible prion states, or strains. However, our understanding of how...
www.researchsquare.com
November 3, 2025 at 10:17 PM
Our new pre-print is out! The result of a wonderful collaboration with the Tanaka lab at RIKEN Center for Brain Science.
We investigate the question: what can yeast prions teach us about the connection between amyloid polymorphism and phenotype?
www.researchsquare.com/article/rs-7...
We investigate the question: what can yeast prions teach us about the connection between amyloid polymorphism and phenotype?
www.researchsquare.com/article/rs-7...
Reposted
These members of the NIH Council of Councils are voicing serious concerns about NIH grant terminations, restructure, and budget cuts
go.nature.com/46Vr8t2
go.nature.com/46Vr8t2
Protect the integrity of the US National Institutes of Health
Letter to the Editor
go.nature.com
July 23, 2025 at 12:03 PM
These members of the NIH Council of Councils are voicing serious concerns about NIH grant terminations, restructure, and budget cuts
go.nature.com/46Vr8t2
go.nature.com/46Vr8t2
Reposted
Learn about our work towards earlier detection of Alzheimer's disease. Despite NIH-funding being delayed, terminated, and uncertain, we are fiercely committed to these goals! Link for donations to support our work is at the bottom of the page, or reach out.
giving.massgeneral.org/stories/earl...
giving.massgeneral.org/stories/earl...
Earlier Detection of Alzheimer’s Could Help Reduce Its Most Devastating Effects
Heidi Jacobs, PhD, is a leader in Alzheimer’s disease research whose personal experience with the disease strengthens her passion for finding a cure — something she is well on her way to achieving.
giving.massgeneral.org
July 23, 2025 at 11:24 PM
Learn about our work towards earlier detection of Alzheimer's disease. Despite NIH-funding being delayed, terminated, and uncertain, we are fiercely committed to these goals! Link for donations to support our work is at the bottom of the page, or reach out.
giving.massgeneral.org/stories/earl...
giving.massgeneral.org/stories/earl...
Reposted
More than a decade-old story, but it resonates again now.
"NIA is in an exceptional predicament. In recent years, it has made big commitments to costly clinical trials and large group projects."
www.nature.com/articles/468...
The value of top-down big projects needs to be reevaluated, especially now
"NIA is in an exceptional predicament. In recent years, it has made big commitments to costly clinical trials and large group projects."
www.nature.com/articles/468...
The value of top-down big projects needs to be reevaluated, especially now
Funding crisis hits US ageing research - Nature
Shortfalls hamper scientists' efforts to address a predicted epidemic of age-related diseases.
www.nature.com
July 20, 2025 at 10:47 PM
More than a decade-old story, but it resonates again now.
"NIA is in an exceptional predicament. In recent years, it has made big commitments to costly clinical trials and large group projects."
www.nature.com/articles/468...
The value of top-down big projects needs to be reevaluated, especially now
"NIA is in an exceptional predicament. In recent years, it has made big commitments to costly clinical trials and large group projects."
www.nature.com/articles/468...
The value of top-down big projects needs to be reevaluated, especially now
I believe in fairness and an end to Big Money in politics.
Was one of the 36,000 ppl at the largest ever Sanders rally and was not paid to be there 😉
Was one of the 36,000 ppl at the largest ever Sanders rally and was not paid to be there 😉
April 13, 2025 at 7:27 AM
I believe in fairness and an end to Big Money in politics.
Was one of the 36,000 ppl at the largest ever Sanders rally and was not paid to be there 😉
Was one of the 36,000 ppl at the largest ever Sanders rally and was not paid to be there 😉