Surrey Lab
@surreylab.bsky.social
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Thomas Surrey's lab @crg.eu MICROTUBULES | Molecular Biochemistry | In vitro Reconstitutions 🦋 posts by lab members
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crg.eu
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surreylab.bsky.social
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surreylab.bsky.social
🚨New paper out @pnas.org!

Do you want to know how do mitotic motors organize the spindle? Wei Xiang's simulations show that just a plus & a minus motor are enough to drive bipolar spindle assembly. Could this explain why kinesin-5 & dynein evolved their unique properties? 🤔
doi.org/10.1073/pnas...
Molecular design principles for bipolar spindle organization by two opposing motors | PNAS
During cell division in animal cells, a bipolar spindle assembles to segregate the chromosomes. Various motor proteins with different properties ar...
www.pnas.org
surreylab.bsky.social
A huge thank you to Michel Steinmetz and his team at the Paul Scherrer Institute for their invaluable collaboration on this project!
surreylab.bsky.social
We're on a roll!🚀
Check our latest research @naturecomms.bsky.social: rdcu.be/ecXzr
We reveal how mosaic MTs faithfully mimic the GTP cap, highlighting lattice expansion (not pf twist) as the structural cornerstone of MT stability and dynamic instability.

Congrats to Juan and everybody involved! 🎉
Hydrolysis-deficient mosaic microtubules as faithful mimics of the GTP cap
Nature Communications - Estévez Gallego et al. present a study demonstrating that mosaic microtubules consisting of a mix of GTP hydrolysis-deficient tubulin mutants are faithful microtubule...
rdcu.be
surreylab.bsky.social
Also, huge congrats to Sabina @bilirubina.bsky.social for not only publishing her work in JCB but also successfully defending her PhD thesis last Friday! 🎉 We're so proud of all you've accomplished over the past few years and excited to see what amazing things you will do next, Dr. Sabina! 🥳
bilirubina.bsky.social
Se acabó! I finally got a #PhD 🎓🥂
4 years of tears & anxiety mixed with euphoria, the most genuine laughs & precious friendships. Fabulously chaotic.
Thanks to all those big little #proteins, inside my body and inside the #microscopy chambers 🧪🔬✨
@crg.eu @upf.edu @prbb.org @surreylab.bsky.social
surreylab.bsky.social
Fresh off the press! 🔬
Our team's new publication in the JCB sheds light on the intricate dance of spindle proteins and microtubules! 🕺💃Sabina (@bilirubina.bsky.social) demonstrates that NuMA acts as a mitotic dynein adaptor, binding and capping minus ends to focus them at mitotic spindle poles!