sykoram.bsky.social
@sykoram.bsky.social
🎉 Great to see our work getting attention — with a few clarifications!
I was pleased to spot recent media coverage of our Nature Communications study — it’s always exciting when fundamental research sparks broader interest.
January 9, 2026 at 12:18 AM
Reposted
A new study in Nature Communications has challenged 50-year-old dogma by revealing that vaccinia virus mRNAs with 5'-poly(A) leaders lack the 5' m7G caps. This unexpected finding reshapes our understanding of poxvirus RNA polymerase function and viral gene expression.

More: rdcu.be/eXksT
Vaccinia virus mRNAs containing long 5′-poly(A)-leaders lack a canonical 5′-methylguanosine cap
Nature Communications - The vaccinia virus produces mRNA lacking the 5′ m7G cap structure. These uncapped mRNAs have long poly(A) leaders and dominate late in infection, suggesting a novel...
rdcu.be
January 5, 2026 at 8:41 AM
🎄 Christmas came early this year!
Very happy to see this story published. This project was particularly meaningful to me, as it is the first study where I developed the original hypothesis, defined the experimental strategy, and generated most of the data underlying the initial manuscript.
Vaccinia virus mRNAs containing long 5′-poly(A)-leaders lack a canonical 5′-methylguanosine cap - Nature Communications
The vaccinia virus produces mRNA lacking the 5′ m7G cap structure. These uncapped mRNAs have long poly(A) leaders and dominate late in infection, suggesting a novel viral strategy for host takeover.
www.nature.com
December 22, 2025 at 10:55 PM
Reposted
🚨 All right, since this is a place of sanity now, let’s kick things off with an open PhD position in my team to work on simulating glycans and their interactions. If you’re passionate about computational biophysics and glycobiology, go ahead and apply! Any shares would be greatly appreciated. 🙃
CHARMM-GUI
www.charmm-gui.org
February 27, 2025 at 7:48 PM