🤩Big thanks to:
@wickedneuro.bsky.social
@brainaddiction.bsky.social
@abepalmer.bsky.social
Lieselot Carrette
Leah Solberg Woods
@snehyanka
Lisa Maturin, Mackenzie Gamble
@Ben_in_vivo

👍Take home: Opioid-induced, sex-specific changes last into withdrawal and abstinence and may contribute to relapse risk, highlighting the SCN as a potential therapeutic target for opioid use disorder.

〰️Link to rhythmic genes: The highest proportion of sex-specific rhythmic genes emerged during abstinence, suggesting that chronic opioid exposure leads to long-lasting, sex-dependent disruptions to the brain’s internal clock, persisting well after drug use ends.

✨During abstinence, females continued to show lasting alterations in stress-related pathways, energy metabolism, and neurotransmission, whereas males exhibited persistent oxidative stress and ongoing changes in cell detoxification processes.

Key findings ⤵️
✨During intoxication and withdrawal, females showed disruptions in genes involved in synaptic signaling, circadian rhythms, and inflammation, while males exhibited activation of DNA damage and immune response pathways.

We performed RNAseq on the SCN from genetically diverse female and male rats during 4 key stages:
1⃣Naïve
2⃣Intoxication
3⃣Acute withdrawal
4⃣Prolonged abstinence
We also linked SCN molecular changes to addiction-like behaviors.

Opioid Use Disorder is a global crisis.
〰️Chronic use worsens sleep/circadian rhythms, which can elevate cravings, negative affect, and relapse risk.
🧠The SCN drives daily rhythms, but how opioids alter its molecular machinery is unknown.

How do opioids disrupt the brain’s internal clock, and how does this differ between sexes? Our new study uses RNAseq to examine the suprachiasmatic nucleus across different opioid exposure states in genetically diverse rats. ✨https://sciencedirect.com/science/article/pii/S2772392525000458

Ryan W. Logan, PhD, is a principal investigator on three recently funded NIH grants that examine the underlying biology of opioid use disorder and the role of sleep and circadian rhythms in relapse vulnerability: direc.to/nKbm

#opioid #sleep #circadian @wickedneuro.bsky.social @cmu.edu

Delighted to be among the ERC Starting Grant awardees for 2025 !!! This grant will investigate how adolescent exploration or risk-taking shapes brain development and behavioral outcomes. More info coming soon ! #ERCStG 🇪🇺

New collaborative study from our team lead by PIN student alum Tanya Pareek examined the effect of chronic alcohol on the brain region involved in contextual memories and identified potential new therapeutic targets. www.biorxiv.org/content/10.1...

Tara Delorme, PhD, a postdoctoral fellow in the lab of Ryan Logan, PhD, is one of 14 researchers from Quebec working in the U.S. to be honored by the Fonds de recherche du Québec-Santé: direc.to/n1KM

#opiod #addiction #communautéFRQ @fondsrechercheqc.bsky.social @wickedneuro.bsky.social

Great 1st day at #AAIC25! We're here for the rest of the week, stop by our @touchscreencog.bsky.social booth that's located in the Canadian Pavilion. 🎉

@maximoprado.bsky.social @westernubrainscan.bsky.social @lisasaksida.bsky.social @timbussey.bsky.social @tcnlab.bsky.social @pradobsky.bsky.social

McGill researchers discover how disrupted daily rhythms can affect adolescent brain development 🧠➡️ www.mcgill.ca/newsroom/cha... @healthsciences.mcgill.ca @douglasresearch.bsky.social

🤔 Interested in examining brain structure and function in unparalleled resolution?
🧠 🔬 The Mesoscopic Integrated Neuroimaging Data (MIND) Platform is searching for a postdoc to assist in the initiative that combines 15.2T MRI and light sheet microscopy.
👇 See the attachment below for details.

Congratulations!!:)

Thrilled to share that I have obtained a permanent position at CNRS 🎉🎉🎉

Thanks so much to everyone that supported me along the way, and especially @faurelab.bsky.social !

New preprint from postdoc, Tara Delorme, in my laboratory!

Opioid use disorder disrupts sleep and the brain’s clock, affecting the SCN, with studies showing sex-specific gene and pathway changes in rats, linking SCN alterations to addiction.

www.biorxiv.org/content/10.1...