Tasuku Ishida
@tasukuishida.bsky.social
うだつの上がらない某製薬会社の研究員からAI創薬の領域に転身しました。でもTPD領域は継続してウォッチしていきます。
Reposted by Tasuku Ishida
Exciting @biorxivpreprint.bsky.social by the groups of @pjcossar.bsky.social and @alessiociulli.bsky.social. They use a molecular glue between 14-3-3 and an intrinsically disordered domain of ERα to develop a molecular glue-based PROTAC recruiting VHL. doi.org/10.1101/2025...
#TPD #ChemSky #ChemBio
#TPD #ChemSky #ChemBio
Induced ubiquitination of the partially disordered Estrogen Receptor alpha protein via a 14-3-3-directed molecular glue-based PROTAC design
Proteins lacking defined ligandable pockets remain challenging drug targets. Here, we develop a molecular glue-based PROTAC (MGPROTACs) approach that chemically conjugates a molecular glue stabilizer ...
doi.org
November 19, 2025 at 9:04 AM
Exciting @biorxivpreprint.bsky.social by the groups of @pjcossar.bsky.social and @alessiociulli.bsky.social. They use a molecular glue between 14-3-3 and an intrinsically disordered domain of ERα to develop a molecular glue-based PROTAC recruiting VHL. doi.org/10.1101/2025...
#TPD #ChemSky #ChemBio
#TPD #ChemSky #ChemBio