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taylorlab.bsky.social
Alex Taylor
@taylorlab.bsky.social
140 followers 110 following 1 posts
Sir Henry Dale Fellow, King's College London. Chemical / Synthetic biologist developing artificial nucleic acids (XNA) for precision medicine. https://www.kcl.ac.uk/people/alex-taylor-1
www.kcl.ac.uk
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taylorlab.bsky.social
Alex Taylor @taylorlab.bsky.social · Sep 8
New paper online! In a distillation of years of painful lessons we've learnt exploring applications of RNA-cleaving DNAzymes as agents for knockdown in cells, we showcase the troubling variety of ways that false positives & negatives can creep in - and how to avoid them. pubs.rsc.org/en/Content/A...
Sources of mismeasurement of RNA knockdown by DNAzymes and XNAzymes
RNA-cleaving olignucleotide catalysts composed of DNA and/or nucleic acid analogues (DNAzymes, modified DNAzymes and XNAzymes) are promising agents for specific knockdown of disease-associated RNAs. H...
pubs.rsc.org
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