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Reposted by T cell Vaccines Lab (Swadling UCL) 🧬👩🏽‍🔬

yEFIS @yefis-immunology.bsky.social · Aug 25

👶✈️ Balancing caregiving and academic travel?

Join Dr. Laura Pallett for "The Dual Demands of Academic Travel and Caregiving"

🗓️ Sept 25 | 🕒15:00 CEST
🔗https://tinyurl.com/yefis2025-ia2

Hosted by the Improving Academia group of yEFIS

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T cell Vaccines Lab (Swadling UCL) 🧬👩🏽‍🔬 @tcellvaccineucl.bsky.social · Jul 3

An HA/NP/IL-1B adenovirus led to a different profile of lung-resident Trms than natural H1N1 infection with the adjuvanted vaccine leading to longer lived lung-resident Trms than infection.
pmc.ncbi.nlm.nih.gov/articles/PMC...
#immunology #vaccine #Tcell #memory

Inflammatory conditions shape phenotypic and functional characteristics of lung-resident memory T cells in mice

Lung tissue-resident memory T cells (TRM) are critical for the local control of respiratory tract infections caused by influenza A viruses (IAV). Here we compare TRM populations induced by intranasal ...

pmc.ncbi.nlm.nih.gov

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T cell Vaccines Lab (Swadling UCL) 🧬👩🏽‍🔬 @tcellvaccineucl.bsky.social · Jun 19

5 charts that show #vaccineswork
www.nature.com/articles/d41...

154 million lives and counting: 5 charts reveal the power of vaccines

But public-health specialists worry that misinformation and funding cuts could affect vaccination rates.

www.nature.com

T cell Vaccines Lab (Swadling UCL) 🧬👩🏽‍🔬 @tcellvaccineucl.bsky.social · Jun 18

www.thelancet.com/journals/ebi...
#tcell #vaccineswork #immunology #vaccine

Intranasal recombinant protein subunit vaccine targeting TLR3 induces respiratory tract IgA and CD8 T cell responses and protects against respiratory virus infection

This study demonstrates that intranasal subunit vaccines containing TLR3-stimulating cationic liposomes effectively induce airway IgA and T cell responses, which could be utilised in future viral pand...

www.thelancet.com

T cell Vaccines Lab (Swadling UCL) 🧬👩🏽‍🔬 @tcellvaccineucl.bsky.social · Jun 18

In vivo challenge after vaccination also showed strong protection for the i.n. administered vaccine, although protection wasn’t compared to the i.m. vaccine. Further evidence for targeting the local mucosa to facilitate protective immunity.

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T cell Vaccines Lab (Swadling UCL) 🧬👩🏽‍🔬 @tcellvaccineucl.bsky.social · Jun 18

Another nice study illustrating that targeting responses to the nasal mucosa could be superior to systemic administration. The CAF09b adjuvant plus recombinant protein in an i.n. vaccine induced better nasal IgA and CD8 responses than i.m. mRNA.

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T cell Vaccines Lab (Swadling UCL) 🧬👩🏽‍🔬 @tcellvaccineucl.bsky.social · Jun 17

Cool to see this upcoming phase 2 clinical trial for aerosolised vaccine formulations, with planned measurements of lung T cell responses
publications.ersnet.org/content/erjo...
#clinicaltrial #tcell #vaccineswork #immunology #vaccine

publications.ersnet.org

T cell Vaccines Lab (Swadling UCL) 🧬👩🏽‍🔬 @tcellvaccineucl.bsky.social · Jun 16

T cell repertoire analysis: www.thelancet.com/journals/ebi...

#tcell #vaccineswork #vaccine #clinicaltrial #immunology

Vaccine-induced T cell responses correlate with reduced risk of severe COVID-19 in a placebo-controlled efficacy trial

Our findings show that higher vaccine-elicited T cell responses are significantly correlated with decreased risk of severe COVID-19, but not with risk of any symptomatic COVID-19. These results repres...

www.thelancet.com

T cell Vaccines Lab (Swadling UCL) 🧬👩🏽‍🔬 @tcellvaccineucl.bsky.social · Jun 16

Full phase 3 study: www.nejm.org/doi/full/10....

Safety and Efficacy of Single-Dose Ad26.COV2.S Vaccine against Covid-19 | NEJM

The Ad26.COV2.S vaccine is a recombinant, replication-incompetent human adenovirus type 26 vector encoding full-length severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike protein in ...

www.nejm.org

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T cell Vaccines Lab (Swadling UCL) 🧬👩🏽‍🔬 @tcellvaccineucl.bsky.social · Jun 16

Lots of food for thought from these two studies.
1) It’s great to see comprehensive repertoire analysis being applied to clinical trial data
2) Could a bespoke T cell targeting vaccine have added benefit?
3) How does site of injection affect systemic vs local immune responses?

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T cell Vaccines Lab (Swadling UCL) 🧬👩🏽‍🔬 @tcellvaccineucl.bsky.social · Jun 16

This follow-up used repertoire analysis and functional assays to show
1) T cells were only partially correlated with the protective immunity to SARS-CoV-2.
2) In those with breakthrough infection, T cell responses correlated with less severe symptoms.
A great analysis overall!

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T cell Vaccines Lab (Swadling UCL) 🧬👩🏽‍🔬 @tcellvaccineucl.bsky.social · Jun 16

New interesting data on the role of T cells in Ad26-COV2.S-mediated immunity to SARS-CoV-2! Back in 2021, a phase 3 study showed that single dose was able to confer protection from symptomatic COVID-19 and reduced severity of any breakthrough infections.

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T cell Vaccines Lab (Swadling UCL) 🧬👩🏽‍🔬 @tcellvaccineucl.bsky.social · Jun 3

We'll be in the City & Guilds Building Exhibition Road, Eureka Zone.

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T cell Vaccines Lab (Swadling UCL) 🧬👩🏽‍🔬 @tcellvaccineucl.bsky.social · Jun 3

Great exhibition Road Festival

South Kensington
7 – 8 June 2025
12.00 ⁠–⁠ 18.00
Led by Imperial College London

hundreds of free workshops, performances, talks & interactive exhibits celebrating science & art

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T cell Vaccines Lab (Swadling UCL) 🧬👩🏽‍🔬 @tcellvaccineucl.bsky.social · Jun 3

Jamie and Leo will be at #ExRdFest Saturday representing IMMPROVE

🧪🧬at the "would you get sick for science" stand 🧪🧬

talking about human challenge, vaccines and immunology!

www.greatexhibitionroadfestival.co.uk

www.imperial.ac.uk/institute-of...

immprove.ac.uk

Home - The Great Exhibition Road Festival

The Great Exhibition Road Festival is an annual celebration of science and the arts in South Kensington, London.

www.greatexhibitionroadfestival.co.uk

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Reposted by T cell Vaccines Lab (Swadling UCL) 🧬👩🏽‍🔬

medRxivpreprint @medrxivpreprint.bsky.social · May 29

Extensive Intra-host evolution and T cell escape by SARS-CoV-2 in a 2.5-year persistent infection of an immunocompromised host https://www.medrxiv.org/content/10.1101/2025.05.28.25328480v1

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T cell Vaccines Lab (Swadling UCL) 🧬👩🏽‍🔬 @tcellvaccineucl.bsky.social · May 16

We also have two new students, Priya and Nistha. Priya will be using wet and dry lab work to identify conserved T cell targets in HCoVs for vaccine design, and Nishtha will be studying how varied inhaled vaccines stimulate innate immunity and effects on T cell responses (3/3)

T cell Vaccines Lab (Swadling UCL) 🧬👩🏽‍🔬 @tcellvaccineucl.bsky.social · May 16

We're proud to host Dr Xiuyuan Lu from Osaka University as part of the IIT & IFReC exchange programme. She comes with great skills in analysing T cell vaccination responses. We're looking forward to her upcoming talk and of course future collaboration! (2/3)

#UCL #IFReC #vaccine

T cell Vaccines Lab (Swadling UCL) 🧬👩🏽‍🔬 @tcellvaccineucl.bsky.social · May 16

Standing room only our recent lab meeting! The group is growing fast, and lots of great science will surely come soon! (1/3)

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T cell Vaccines Lab (Swadling UCL) 🧬👩🏽‍🔬 @tcellvaccineucl.bsky.social · Apr 10

(2/2)

My final thought for the day, is that from mechanistic insights or enhancing and developing medicines, it’s exciting to see quantitative research taking increasing space in immunology. Let’s keep the momentum going!

Postdoc Peter, signing off.

#qimmunoday

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T cell Vaccines Lab (Swadling UCL) 🧬👩🏽‍🔬 @tcellvaccineucl.bsky.social · Apr 10

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Another successful #qimmuno day has drawn to a close, but discussions continue in the pub around the corner! Congrats to the organising committee @qimmuno.bsky.social for an excellent day and to all the speakers for engaging talks.

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T cell Vaccines Lab (Swadling UCL) 🧬👩🏽‍🔬 @tcellvaccineucl.bsky.social · Apr 10

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Xiaowen Chen was the final presenter, and presented novel research into how we can infer resource competition from dynamic abundance data. A very interesting topic, which has some cool potential overlaps with T and B cell competition for antigens and/or cytokines.

Now for posters!

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T cell Vaccines Lab (Swadling UCL) 🧬👩🏽‍🔬 @tcellvaccineucl.bsky.social · Apr 10

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Pebs Edwards presented some interesting data on the TCR repertoire in patients with lynch syndrome. A personal highlight for me was the 2 year persistence of neo-antigen clonotypes with apparent subsequent reactivation in at least one patient.

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T cell Vaccines Lab (Swadling UCL) 🧬👩🏽‍🔬 @tcellvaccineucl.bsky.social · Apr 10

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Final set of talks now. Aubin Ramon started by describing his work to develop NanoMelt for nanobody thermostability assessment. The model uses ensemble learning on just 640 sequences, but accurately predicted Tm in a selection of nanobodies with at least 30% distance from the training set.

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T cell Vaccines Lab (Swadling UCL) 🧬👩🏽‍🔬 @tcellvaccineucl.bsky.social · Apr 10

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Alastar Phelan then spoke about his mathematical modelling approach to enhance signal detection in dual pulse nucleoside labelling experiments for improving cell cycle analysis.

Both speakers showcased their work really well, armed with only a pen and whiteboard!

#qimmunoday

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