The Babak Lab
@thebabaklab.bsky.social
150 followers
93 following
85 posts
Research group of Prof. Maria (Masha) Babak at City University of Hong Kong
#anticancerdrugdiscovery #globalpublichealth #AI-assisteddrugdisovery
thebabaklab.com
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The Babak Lab
@thebabaklab.bsky.social
· Jun 30
Encorafenib, Cetuximab, and mFOLFOX6 in BRAF-Mutated Colorectal Cancer | NEJM
First-line treatment with encorafenib plus cetuximab (EC) with or without chemotherapy
(oxaliplatin, leucovorin, and fluorouracil [mFOLFOX6]) for BRAF V600E–mutated metastatic
colorectal cancer, an...
www.nejm.org
The Babak Lab
@thebabaklab.bsky.social
· Jun 27
Overcoming cisplatin resistance via deep learning-assisted de novo design of platinum complexes
Resistance to cisplatin poses a significant challenge in cancer treatment for patients globally. Despite the continuous efforts of both the pharmaceutical industry and academia, no new platinum drugs ...
chemrxiv.org
The Babak Lab
@thebabaklab.bsky.social
· Jun 25
A framework for evaluating the chemical knowledge and reasoning abilities of large language models against the expertise of chemists - Nature Chemistry
Large language models are increasingly used for diverse tasks, yet we have limited insight into their understanding of chemistry. Now ChemBench—a benchmarking framework containing more than 2,700 ques...
www.nature.com
The Babak Lab
@thebabaklab.bsky.social
· Jun 23
Neoadjuvant and Adjuvant Pembrolizumab in Locally Advanced Head and Neck Cancer | NEJM
The benefit of the addition of perioperative pembrolizumab to standard care with surgery
and adjuvant therapy for patients with locally advanced head and neck squamous-cell
carcinoma (HNSCC) is unc...
www.nejm.org
The Babak Lab
@thebabaklab.bsky.social
· Jun 21
Overcoming cisplatin resistance via deep learning-assisted de novo design of platinum complexes
Resistance to cisplatin poses a significant challenge in cancer treatment for patients globally. Despite the continuous efforts of both the pharmaceutical industry and academia, no new platinum drugs ...
chemrxiv.org
The Babak Lab
@thebabaklab.bsky.social
· Jun 18
Iron at the crossroads of host–microbiome interactions in health and disease - Nature Microbiology
Choi and Bessman discuss the role of iron in host–microbiome interactions, including iron acquisition strategies by the host, commensals and pathogens, and implications for disease and therapeutics.
nature.com
The Babak Lab
@thebabaklab.bsky.social
· Jun 16
Anti-sporozoite monoclonal antibody for malaria prevention: secondary efficacy outcome of a phase 2 randomized trial - Nature Medicine
A single dose of the anti-sporozoite monoclonal antibody CIS43LS can achieve durable, sterile protection against Plasmodium falciparum infection.
nature.com
The Babak Lab
@thebabaklab.bsky.social
· Jun 11
Development and validation of an autonomous artificial intelligence agent for clinical decision-making in oncology - Nature Cancer
Ferber et al. present an autonomous artificial intelligence agent system for deployment of specialized medical oncology computational tools, validating their system across various clinical scenarios r...
www.nature.com
