Thanks @cancerdynamics.bsky.social for highlighting this interview with @columbiacancer.bsky.social for Blood Cancer Awareness Month and our work in @cohesinlab

🚨 Excited to share our new preprint: Stag2 dependent chromatin remodeling enforces the erythroid-specific Gata1 cistrome. This work was led by Columbia VP&S MD student Varun Sudunagunta (‼️ Program Directors: Varun is applying to IM residencies this year!) www.biorxiv.org/content/10.1...

Can’t wait to read it John!

Educational Session: “Dysregulation of nuclear topology in cancer: Clinical implications and emerging mechanisms”
Presenter:
@thedoctorisvin.bsky.social
April 25, 2025, 3:30 PM - 3:50 PM CST/ 4:30 PM - 4:50 PM EST

If you’re at @theaacr.bsky.social don’t miss today’s session on 3D Topology & Cancer featuring giants of the field: Jane Skok @nyulangone.bsky.social & Brad Cairns @utah.edu

Imposter syndrome at an all time high! 😬

Proud to represent @cohesinlab.bsky.social @columbiacancer.bsky.social #AACR25

And is it just FLI1? We don’t think so! Actually a HUGE part of this mechanism coming into focus was it helps us unify our prior PU.1 finding and may explain your zebrafish runx1 data that has been the inspiration for so much of our work! journals.biologists.com/dev/article/...

Nope! No change in my overall expression by RNA or protein—but a redistribution of the protein towards a much higher chromatin-bound fraction.

And we think this disordering of the FLI1 cistrome is a big part of the mechanism!

Hey! Check out @drjanexu.bsky.social discussing @cohesinlab.bsky.social’s first preprint on @isehsociety.bsky.social simply blood preprint watch! www.simplyblood.org/2025/04/prep...

👇👇 Check out our first pre-print!

@damonrunyon.org @dorisdukefdn.bsky.social @columbiacancer.bsky.social @clevelandclinic.bsky.social @mskcancercenter.bsky.social @euralumni.bsky.social @columbiamed.bsky.social @cohesinlab.bsky.social