the Hoffman Lab
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thehoffmanlab.bsky.social
the Hoffman Lab
@thehoffmanlab.bsky.social
We are The Hoffman Lab based at Bielefeld University, Germany!

Our group aims to understand the genetic basis of fitness variation in and among natural populations. We work on pinnipeds 🦭, fungi 🍄 and birds 🐥.

https://thehoffmanlab.com/
We found that viability selection targets exonic evolutionarily conserved mutations 🤔 Read more: doi.org/10.1016/j.cu...
Redirecting
doi.org
December 8, 2025 at 12:16 PM
October 10, 2025 at 7:52 AM
For the full publication, check out Nature Ecology and Evolution
@natecoevo.nature.com 👉 www.nature.com/articles/s41... 6/6
www.nature.com
September 22, 2025 at 1:47 PM
For a lay summary by the university, check out the press release (in German) 👉 aktuell.uni-bielefeld.de/2025/08/11/s... 5/6
Schädliche Gene mindern den Paarungserfolg bei Birkhühnern
Die Studie eines Forschungsteams unter der Leitung der Biologin Rebecca Chen wurde im Fachjournal Nature Ecology & Evolution veröffentlicht.
aktuell.uni-bielefeld.de
September 22, 2025 at 1:35 PM
We analysed if coding and non-coding mutations have different fitness effects, and showed that mutations in regulatory regions of the genome seem to play a disproportionate role in explaining lifetime reproductive success! 4/6
September 22, 2025 at 1:35 PM
Black grouse aggregate on leks where males fight to defend non-resource holding territories. Their ability to attend leks during the lekking season is critical to secure matings with females, and we show that lek attendance indicates their underlying genetic quality. 3/6
September 22, 2025 at 1:35 PM
Our PhD candidate @rebeccachen.bsky.social showed that predicted deleterious mutations, both in homo- and heterozygosity, are associated with lower lek attendance in black grouse males, which reduces their mating success. 2/6
September 22, 2025 at 1:35 PM
Reposted by the Hoffman Lab
@annekep.bsky.social shows us a super impressive long term study in Antarctica fur seals to explore interactions between inbreeding and climate change 🦭
August 20, 2025 at 10:08 AM
August 19, 2025 at 7:52 AM