Unreal/Unreal Tournament! A multiplayer juggernaut when it was released (with a fire soundtrack), but if you ask people today what Unreal is they're gonna probably answer "a game engine almost every developer uses."

*taps the sign*

This isn't a spoiler because it's not in the show, but the Ikuto Yamashita's "fan art" of the Zakrello is something.

Rebirth has the distinction of being the first and only game I've invested many hours into but never finished. At least it came with another "Collapsed Expressway"-esque Suzuki banger in the Mt Corel song.

Who controls what medical literature it uses? There's a lot of bogus published research that's just driving home the author's political point or selling a drug that doesn't work. Citation counts are also inflated (people cite a paper because similar studies to theirs cite it).