Alex Mackintosh
@thymelicus.bsky.social
210 followers 200 following 6 posts
Population genetics | Uppsala
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Reposted by Alex Mackintosh
vincentcastric.bsky.social
Very happy to announce that the next POPGROUP meeting will take place in Lille on 7-9 January !

Follow ‪@popgroup2026.bsky.social for all updates.

📢 Please share widely ! 📢‬
popgroup2026.bsky.social
Exciting news!
The next #PopGroup meeting will take place in Lille 🍟, France, 7–9 January 2026 – just 1 hour by train from London, Brussels, and Paris.

This year, PopGroup will also host ALPHY, the annual meeting of Evolutionary Genomics.

More info: populationgeneticsgroup.org.uk

See you there !
Population Genetics group 59
populationgeneticsgroup.org.uk
thymelicus.bsky.social
You went to preschool with Naoyuki Takahata?!
thymelicus.bsky.social
HiC. Not particularly cheap, but it is probably the only (non-trio) method where you can accurately phase SNPs across a whole chromosome.
Reposted by Alex Mackintosh
bobmuscarella.bsky.social
🚨New paper out in PNAS🚨

Soil eDNA reflects regionally dominant species rather than local composition of tropical tree communities 🧬🌿🌳🌺🧬

We asked about the spatial scale of biodiversity captured by samples of DNA from tropical soils #Luquillo #eDNA. A short 🧵....

www.pnas.org/doi/10.1073/...
PNAS
Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...
www.pnas.org
Reposted by Alex Mackintosh
biorxiv-genomic.bsky.social
A model-free method for genealogical inference without phasing and its application for topology weighting https://www.biorxiv.org/content/10.1101/2025.07.22.666161v1
Reposted by Alex Mackintosh
thymelicus.bsky.social
Our new work on estimation of background selection (BGS) is up on bioRxiv.

We investigated the problem using simulations and also developed a method for joint inference of BGS, demography and partial selfing from windowed site frequency spectra along the genome.

Feedback is welcome. #BGS
biorxiv-evobio.bsky.social
Estimating the reduction in genetic diversity from background selection under non-equilibrium demography and partial selfing https://www.biorxiv.org/content/10.1101/2025.06.30.662370v1
thymelicus.bsky.social
Our new work on estimation of background selection (BGS) is up on bioRxiv.

We investigated the problem using simulations and also developed a method for joint inference of BGS, demography and partial selfing from windowed site frequency spectra along the genome.

Feedback is welcome. #BGS
biorxiv-evobio.bsky.social
Estimating the reduction in genetic diversity from background selection under non-equilibrium demography and partial selfing https://www.biorxiv.org/content/10.1101/2025.06.30.662370v1
Reposted by Alex Mackintosh
couplingdmi.bsky.social
#PopGen New preprint of the team on the discovery of a very high rate of polymorphic duplication in a marine bivalve.

Imagine looking at the distribution of the allelic coverage fraction at heterozygous calls in an indivdual and getting this distribution 👇 😱😱😱
Reposted by Alex Mackintosh
biorxiv-evobio.bsky.social
The 229 chromosomes of the Atlas blue butterfly reveal rules constraining chromosome evolution in Lepidoptera https://www.biorxiv.org/content/10.1101/2025.03.14.642909v1
Reposted by Alex Mackintosh
Reposted by Alex Mackintosh
kamilsjaron.bsky.social
🚨Registration open🚨 1st - 6th of June, me, Katie Jenike, @rayanchikhi.bsky.social and Gene Myers will run a week long workshop on k-mers for biodiversity genomics organised by @connectingscience.bsky.social at @sangerinstitute.bsky.social. Join us & get equipped to wrestle large genomic datasets!
https://coursesandconferences.wellcomeconnectingscience.org/event/k-mer-workshop-for-biodiversity-genomics-20250601/
thymelicus.bsky.social
The test requires just one unphased diploid from each population and makes few assumptions about the underlying demographic history. I hope that others find the paper/method useful. 2/2
thymelicus.bsky.social
My and Derek Setter's work on gene flow is now published in the latest issue of Genetics. We show that it is possible to detect past gene flow between two populations by summarising the asymmetry in pop-specific external branch lengths. 1/2
tinyurl.com/5ff8ch9e
Genealogical asymmetry under the isolation with migration model and a two-taxon test for gene flow
Abstract. Methods for detecting gene flow between populations often rely on asymmetry in the average length of particular genealogical branches, with the A
tinyurl.com
thymelicus.bsky.social
Sadly I am no longer working on butterfly genomics. I am currently focused on popgen methods with application to plant genomes (mostly simulated plant genomes for now...) Perhaps I'll return one day 🦋
Reposted by Alex Mackintosh