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Tim Frayling @timfrayling.bsky.social · 8d

Congratulations to our Liza Darrous for winning the women in data science award last week: tinyurl.com/lizaprize

Still buzzing from an incredible day at WiDS Belgium 2025 👩‍💻 ✨ ! Usually WiDS leaves me inspired by all the amazing women sharing their work on stage. This year, I had the chance to be on stage… | L...

Still buzzing from an incredible day at WiDS Belgium 2025 👩‍💻 ✨ ! Usually WiDS leaves me inspired by all the amazing women sharing their work on stage. This year, I had the chance to be on stage myse...

tinyurl.com

Tim Frayling @timfrayling.bsky.social · Sep 8

For more details about the Swiss personalised Health Network and the safe way trained researchers can work with data from multiple hospitals : sphn.ch/network/proj...

Projects - SPHN

Projects Implementation Projects The SPHN implementation projects aim at developing the core infrastructure which is required to make health-related data FAIR* at the national level. Using a top-down ...

sphn.ch

Tim Frayling @timfrayling.bsky.social · Sep 8

thanks to @laraedw001.bsky.social for highlighting this micro.green-park.co.uk/hdrs/. I suggest whoever gets this position, pops over to Switzerland as the SPHN have achieved great things with consented data from 10% of the population available for study a few months after application & in a TRE

HDRS

micro.green-park.co.uk

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Tim Frayling @timfrayling.bsky.social · Sep 8

When you say "nobody" do you mean "nobody outside of your health care providers" ? your hospital will use your data all the time to help audit and improve their services ?

Tim Frayling @timfrayling.bsky.social · Sep 5

smart work aged 8. but possibly redundant for 17 years time when birth rates in europe may be 0.1 per couple. Maybe aged 85 : lose large amount of money to pay for private social care ?

Tim Frayling @timfrayling.bsky.social · Sep 5

Oh dear. Sad and presumably another lead statistician to be fired ? www.bbc.com/news/live/c5...

US economy adds fewer jobs than expected in August, confirming slowdown

After the previous month's release, Trump fired then-Bureau of Labor Statistics chief Erika McEntarfer.

www.bbc.com

Tim Frayling @timfrayling.bsky.social · Sep 1

thanks Laura. Yes I think the 1st slide on PRS talks needs to be "do not compare PRS to clinical genetics, compare to the common, equally bad & equally good , stuff your doctor measures all the time to stratify you - LDLC, blood pressure, family history, ancestry and BMI" (to add to your age & sex)

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Tim Frayling @timfrayling.bsky.social · Sep 1

yes . I guess my slight air of frustration is that we have known for while that PRS are complementary to other risk factors e.g. journals.plos.org/plosmedicine...

Polygenic risk scores in cardiovascular risk prediction: A cohort study and modelling analyses

Luanluan Sun and colleagues investigate whether adding polygenic risk scores to conventional risk factors of cardiovascular disease helps predict disease risk.

journals.plos.org

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Tim Frayling @timfrayling.bsky.social · Aug 30

the first one does not seem to be the right question.

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Tim Frayling @timfrayling.bsky.social · Aug 30

great stuff but why compare with PRS ? I do not think anyone is suggesting we should use one and not the other ? Can we not have our PRS cake and eat the EHRs :-)

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Tim Frayling @timfrayling.bsky.social · Aug 20

Amazing study. A simple but important question affecting up to 50% of the population yet previously understudied . And an exemplar in the power of multi-modal data linkage. www.bristol.ac.uk/alspac/news/...

2025: Periods and GCSE results | Avon Longitudinal Study of Parents and Children | University of Bristol

www.bristol.ac.uk

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Tim Frayling @timfrayling.bsky.social · Aug 18

Deadline 31/08. Join a friendly team in the heart of Europe. Build your research career in human genetics & genomics using data from millions of individuals to address important causes and consequences of disease. Apply here lnkd.in/dyZcgc-g More information on the team here: lnkd.in/dzZ2aU4Z

This link will take you to a page that’s not on LinkedIn

lnkd.in

Tim Frayling @timfrayling.bsky.social · Aug 18

New position in Geneva jobs.unige.ch/www/wd_porta...

Maître assistant-e - Fonds National (6461)

jobs.unige.ch

Tim Frayling @timfrayling.bsky.social · Aug 8

similar scenario for height. even though the common genetics is "saturated" the height range one person could be based on their PRS is very wide. (which is of course a separate argument compared to using PRS to stratify people)

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Tim Frayling @timfrayling.bsky.social · Aug 7

nice summary thanks Andrea. I wonder if this challenge will become easier in a few years if and when clinicians inform a young adult patient they would like to "do" their genetics at the same time as their first blood pressure/FEV/LDL-cholesterol etc test.

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Reposted by Tim Frayling

fbm-unil.bsky.social @fbm-unil.bsky.social · Aug 7

Dirigée par @zkutalik.bsky.social et @rjhfmstr.bsky.social à la @fbm-unil.bsky.social, au @sib.swiss et à #unisanté, une nouvelle étude publiée dans @nature.com présente une méthode computationnelle innovante pour étudier ces effets liés à l’origine parentale.
🔗 www.nature.com/articles/s41...

Parent-of-origin effects on complex traits in up to 236,781 individuals - Nature

A novel multistep strategy reveals how parent-of-origin effects shape complex traits in large-scale biobanks.

www.nature.com

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Tim Frayling @timfrayling.bsky.social · Aug 2

Best of British : Black Sabbath’s Paranoid played by the Coldstream guards to commemorate Ozzy Osborne

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Tim Frayling @timfrayling.bsky.social · Aug 1

well done part I @erinltempleman.bsky.social

erinltempleman.bsky.social @erinltempleman.bsky.social · Jul 23

🚨Big news! Excited to share my first PhD paper!🎉
We validated & improved a T1D risk model using TrialNet data (originally from TEDDY), boosting accuracy 📈
bmcmedicine.biomedcentral.com/articles/10....
Try the web tool 👉 t1dpredictor.diabetesgenes.org
#T1D #RiskPrediction #PrecisionMedicine #TrialNet

Development and recalibration of a multivariable type 1 diabetes prediction model for type 1 diabetes across multiple screening studies - BMC Medicine

Background Accurate type 1 diabetes prediction is important to facilitate screening for pre-clinical type 1 diabetes to enable potential early disease-modifying interventions and to reduce the risk of...

bmcmedicine.biomedcentral.com

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Tim Frayling @timfrayling.bsky.social · Jul 16

Does it even make sense to compare PGS to proteomic risk scores though ? one is a once in a lifetime assay that costs about $40. the other....is not. The most relevant comparison for proteomic scores is likely to be routine biochemistry ?

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Tim Frayling @timfrayling.bsky.social · Jul 14

The Pope Song by Tim Minchin would be a controversial choice

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Tim Frayling @timfrayling.bsky.social · Jul 14

Which sports (and formats) come closest to test match cricket where no runs / points / goals / scores are being made but the tension and adrenaline levels are so high (for players and spectators alike )? www.espncricinfo.com/series/india...

3rd Test, Lord's, July 10 - 14, 2025, India tour of England (Ravindra Jadeja 61*, Shoaib Bashir 1/6, ENG vs IND live score, 3rd Test, day 4, Lord's, London, July 10 - 14, 2025

Check England vs India 3rd Test 2025 live cricket score from London. Get the live score updates and ball by ball commentary of ENG vs IND 3rd Test, 2025. Fastest scorecard and detailed analysis of the...

www.espncricinfo.com

Tim Frayling @timfrayling.bsky.social · Jul 12

Best wishes to this sports star Amanda Anismova. You don’t beat Anya Sabalenka in the semi finals of Wimbledon without being a superb tennis player : www.theguardian.com/sport/2025/j...

Iga Swiatek races to first Wimbledon title with 6-0, 6-0 thrashing of Anisimova

Iga Swiatek crushed Amanda Anisimova in the most one-sided Wimbledon final for 114 years, racing to a 6-0, 6-0 victory in only 57 minutes

www.theguardian.com

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Tim Frayling @timfrayling.bsky.social · Jul 9

BBC radio 4´s more or less programme on obesity : www.bbc.co.uk/sounds/play/...

More or Less - Can drinking one less bottle of coke a day halve obesity? - BBC Sounds

Plus, the UK’s expensive electricity, church counts and babies in the City of London.

www.bbc.co.uk

Tim Frayling @timfrayling.bsky.social · Jul 7

true. given the input and outputs involved maybe the MRC and WT will chip in :-)

Tim Frayling @timfrayling.bsky.social · Jul 6

Wow. Amazing investigative journalism: observer.co.uk/news/nationa...