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Ting Wu Lab

@tingwu-lab.bsky.social

200 followers 710 following 1 posts

We are the Ting Wu Lab @ HMS. Our laboratory studies how chromosome behavior and positioning influence genome function, with implications for gene regulation, genome stability, and disease. Managed by WuLab members https://www.transvection.org/home

www.transvection.org

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Ting Wu Lab @tingwu-lab.bsky.social · Aug 13

What better way to launch our new account with the publication of @jmstein.bsky.social latest paper from the lab! 🧪 Check out the 🧵 below to learn more about tkPAINT and how we use it to image proteins, DNA, and RNA in the nucleus using DNA-PAINT.

Johannes Stein @jmstein.bsky.social · Aug 13

(1/n) DNA-PAINT imaging inside the nucleus at single antibody resolution using TIRF? Ultrathin sectioning makes it happen!

Grateful to share my postdoctoral work introducing “tomographic & kinetically-enhanced DNA-PAINT” or in brief: tkPAINT. Out in @pnas.org!
doi.org/10.1073/pnas...
👇🧵

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Reposted by Ting Wu Lab

Laura Breimann @laurabreimann.bsky.social · Aug 16

Excited that our paper was published in Science Advances 🧪
Great work by first author Merrick Pierson Smela who will carry this work forward in his new start-up!

The Wyss Institute at Harvard University @wyssinstitute.bsky.social · Aug 15

Wyss researchers have induced human stem cells to initiate meiosis – a key step in creating eggs and sperm – in the lab for the first time. This work was published in @science.org Advances.

Recapitulating egg and sperm development in the dish

By Benjamin Boettner (BOSTON) — More than one-sixth of adults around the world experience infertility in their lifetime. There is a high unmet need not only for increased access to affordable, high-q...

wyss.harvard.edu

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Reposted by Ting Wu Lab

Cedric Boeckx @cedricboeckx.bsky.social · Aug 14

New preprint from @apombo1.bsky.social’s lab on gene regulation; insights into super-enhancers and their role in establishing complex regulatory networks of cell-type specific interactions with other enhancers and genes with specialized cellular functions 🧪🧬
www.biorxiv.org/content/10.1...

Specialised super-enhancer networks in stem cells and neurons

Super-enhancers (SEs) are clusters of enhancers with high transcriptional activity that play essential roles in defining cell identity through regulation of nearby genes. SEs preferentially form multi...

www.biorxiv.org

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Reposted by Ting Wu Lab

Laura Breimann @laurabreimann.bsky.social · Aug 13

Excited that tkPAINT is finally published! 🔬 Check out the latest version at @pnas.org and see this thread from @jmstein.bsky.social for the overview! Thank you for this fun collaboration! 🤗

Johannes Stein @jmstein.bsky.social · Aug 13

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Reposted by Ting Wu Lab

Eric Joyce @ericjoyce.bsky.social · Aug 14

🚨New preprint from the lab🚨
🧬 What keeps certain chromatin domains anchored at the nuclear periphery? Our new genome-wide HiDRO screen uncovers a key role for RNA-binding protein hnRNPK.
www.biorxiv.org/content/10.1...

Mechanistic and Epigenetic Partitioning of Lamina-Associated Chromatin Revealed by a Genome-Wide Imaging Screen

The nuclear periphery is a key site for heterochromatin organization in eukaryotic cells, where lamina-associated domains (LADs) promote transcriptional repression and genome stability. Despite their ...

www.biorxiv.org

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Ting Wu Lab @tingwu-lab.bsky.social · Aug 13

Johannes Stein @jmstein.bsky.social · Aug 13

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