Toni Martinez
@tonimarber.bsky.social
PhD 🧬 - Translational Oncology Multidisciplinary Group (GMOT) at University of Balearic Islands (UIB) - Mitochondria, p53 and colorectal cancer
Not all TP53 mutations are equal.
This study reveals that R175H and R175G variants in ovarian cancer differ in partners and pathways driving platinum resistance - with CHD1–IL7R emerging as mutation-specific therapeutic targets.
#OvarianCancer
www.nature.com/articles/s41...
This study reveals that R175H and R175G variants in ovarian cancer differ in partners and pathways driving platinum resistance - with CHD1–IL7R emerging as mutation-specific therapeutic targets.
#OvarianCancer
www.nature.com/articles/s41...
Distinct functional heterogeneity of TP53 R175 mutations in platinum-resistant ovarian cancer: unveiling molecular mechanisms and therapeutic targets - Cell Death & Disease
Cell Death & Disease - Distinct functional heterogeneity of TP53 R175 mutations in platinum-resistant ovarian cancer: unveiling molecular mechanisms and therapeutic targets
www.nature.com
November 23, 2025 at 11:18 AM
Not all TP53 mutations are equal.
This study reveals that R175H and R175G variants in ovarian cancer differ in partners and pathways driving platinum resistance - with CHD1–IL7R emerging as mutation-specific therapeutic targets.
#OvarianCancer
www.nature.com/articles/s41...
This study reveals that R175H and R175G variants in ovarian cancer differ in partners and pathways driving platinum resistance - with CHD1–IL7R emerging as mutation-specific therapeutic targets.
#OvarianCancer
www.nature.com/articles/s41...
Mutant p53 fuels breast cancer growth through a positive feedback loop with PDK1, boosting proliferation and migration.
Inhibiting PDK1 enhances the effect of APR-246, pointing to a promising combo therapy for TP53-mutant tumors.
#p53 #CancerMetabolism
onlinelibrary.wiley.com/doi/10.1111/...
Inhibiting PDK1 enhances the effect of APR-246, pointing to a promising combo therapy for TP53-mutant tumors.
#p53 #CancerMetabolism
onlinelibrary.wiley.com/doi/10.1111/...
Mutant p53 Regulates Pyruvate Dehydrogenase Kinase 1 (PDK1) to Promote Proliferation and Migration in Breast Cancer
PDK1 is a direct transcriptional repression target of wtp53 and mutp53 can sustain its own stability by upregulating PDK1 in breast cancer.
onlinelibrary.wiley.com
November 23, 2025 at 11:18 AM
Mutant p53 fuels breast cancer growth through a positive feedback loop with PDK1, boosting proliferation and migration.
Inhibiting PDK1 enhances the effect of APR-246, pointing to a promising combo therapy for TP53-mutant tumors.
#p53 #CancerMetabolism
onlinelibrary.wiley.com/doi/10.1111/...
Inhibiting PDK1 enhances the effect of APR-246, pointing to a promising combo therapy for TP53-mutant tumors.
#p53 #CancerMetabolism
onlinelibrary.wiley.com/doi/10.1111/...
Featured paper: “Correlation between p53 IHC and TP53 testing in endometrial carcinomas”
🧬 Strong overall concordance, but a small group shows WT p53 staining despite TP53 mutations - key for diagnosis & treatment.
#p53 #oncology #mutations #diagnosis
🔗 doi.org/10.1111/his....
🧬 Strong overall concordance, but a small group shows WT p53 staining despite TP53 mutations - key for diagnosis & treatment.
#p53 #oncology #mutations #diagnosis
🔗 doi.org/10.1111/his....
Correlation between P53 immunohistochemical staining and TP53 molecular testing in endometrial carcinomas: a detailed assessment of discrepant cases with implications for patient management
Our study demonstrates a good overall concordance between p53 immunohistochemical staining and TP53 molecular results in endometrial carcinomas. The concordance can be increased by reviewing the p53 ....
doi.org
November 3, 2025 at 8:10 PM
Featured paper: “Correlation between p53 IHC and TP53 testing in endometrial carcinomas”
🧬 Strong overall concordance, but a small group shows WT p53 staining despite TP53 mutations - key for diagnosis & treatment.
#p53 #oncology #mutations #diagnosis
🔗 doi.org/10.1111/his....
🧬 Strong overall concordance, but a small group shows WT p53 staining despite TP53 mutations - key for diagnosis & treatment.
#p53 #oncology #mutations #diagnosis
🔗 doi.org/10.1111/his....
Proud to see this story come to life after years of work!
If you’re interested in how mutant p53 rewires mitochondrial metabolism to shape tumor adaptation and chemoresistance, take a look 👇
doi.org/10.1016/j.bb...
#p53 #Mitochondria #ColorectalCancer #Oxaliplatin #Metabolism #CancerResearch
If you’re interested in how mutant p53 rewires mitochondrial metabolism to shape tumor adaptation and chemoresistance, take a look 👇
doi.org/10.1016/j.bb...
#p53 #Mitochondria #ColorectalCancer #Oxaliplatin #Metabolism #CancerResearch
Redirecting
doi.org
October 29, 2025 at 9:58 AM
Proud to see this story come to life after years of work!
If you’re interested in how mutant p53 rewires mitochondrial metabolism to shape tumor adaptation and chemoresistance, take a look 👇
doi.org/10.1016/j.bb...
#p53 #Mitochondria #ColorectalCancer #Oxaliplatin #Metabolism #CancerResearch
If you’re interested in how mutant p53 rewires mitochondrial metabolism to shape tumor adaptation and chemoresistance, take a look 👇
doi.org/10.1016/j.bb...
#p53 #Mitochondria #ColorectalCancer #Oxaliplatin #Metabolism #CancerResearch
This work was a collaborative effort between @gmot16.bsky.social and colleagues from the University of Verona 🇮🇹, Prof. Massimo Donadelli and Dr. Alessandra Fiore. Huge thanks to @peremmb.bsky.social, @jordio2.bsky.social, @jordisastreserra.bsky.social, and @danielponsmiro.bsky.social!
October 29, 2025 at 9:58 AM
This work was a collaborative effort between @gmot16.bsky.social and colleagues from the University of Verona 🇮🇹, Prof. Massimo Donadelli and Dr. Alessandra Fiore. Huge thanks to @peremmb.bsky.social, @jordio2.bsky.social, @jordisastreserra.bsky.social, and @danielponsmiro.bsky.social!
We also observed that p53-R273H correlates with poor prognosis and metastatic behavior, promoting cell migration through vimentin upregulation - linking this mutation to EMT and enhanced invasive potential. 🧩
October 29, 2025 at 9:58 AM
We also observed that p53-R273H correlates with poor prognosis and metastatic behavior, promoting cell migration through vimentin upregulation - linking this mutation to EMT and enhanced invasive potential. 🧩
The primary CRC line showed diverse subpopulations under oxaliplatin, with some partially resistant, while the metastatic line responded uniformly - highlighting cell plasticity and tumor heterogeneity in treatment adaptation. 🔬
October 29, 2025 at 9:58 AM
The primary CRC line showed diverse subpopulations under oxaliplatin, with some partially resistant, while the metastatic line responded uniformly - highlighting cell plasticity and tumor heterogeneity in treatment adaptation. 🔬
We found that p53 R273H triggers mitochondrial biogenesis via PGC1β and NRF1, driving a metabolic shift that boosts energy and cell migration in primary colorectal cancer - revealing how metabolism fuels tumor adaptation under chemo stress. ⚡
October 29, 2025 at 9:58 AM
We found that p53 R273H triggers mitochondrial biogenesis via PGC1β and NRF1, driving a metabolic shift that boosts energy and cell migration in primary colorectal cancer - revealing how metabolism fuels tumor adaptation under chemo stress. ⚡
Reposted by Toni Martinez
Torn del Dr. Toni Martínez @tonimarber.bsky.social per explicar la seva tesi doctoral realitzada al grup @gmot16.bsky.social
September 25, 2025 at 10:36 AM
Torn del Dr. Toni Martínez @tonimarber.bsky.social per explicar la seva tesi doctoral realitzada al grup @gmot16.bsky.social
Reposted by Toni Martinez
Per altra banda, el Dr. Toni Martínez @tonimarber.bsky.social, sota la direcció dels Drs. J. Oliver i J. Sastre, va centrar-se en l’estudi d’una mutació freqüent de la proteïna p53 i com pot impactar en la progressió del càncer colorectal. Enhorabona i bona sort amb el que t’espera a partir d’ara!🎉🔬
July 31, 2025 at 4:01 PM
Per altra banda, el Dr. Toni Martínez @tonimarber.bsky.social, sota la direcció dels Drs. J. Oliver i J. Sastre, va centrar-se en l’estudi d’una mutació freqüent de la proteïna p53 i com pot impactar en la progressió del càncer colorectal. Enhorabona i bona sort amb el que t’espera a partir d’ara!🎉🔬