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Reposted by Tommaso Patriarchi

Joachim Goedhart @joachimgoedhart.bsky.social · 13d

Time-resolved fluorescent proteins expand fluorescent microscopy in temporal and spectral domains.
Is it impressive? Yes
Is it new? No
Should you use it? Probably not.
www.cell.com/cell/fulltex...

Time-resolved fluorescent proteins expand fluorescent microscopy in temporal and spectral domains

A family of rationally designed time-resolved fluorescent proteins with controllable lifetimes across the visible spectrum enables simultaneous multiplexed live imaging, super-resolution microscopy, a...

www.cell.com

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Tommaso Patriarchi @tpatriarchi.bsky.social · Aug 28

Congrats Martin, great work!

Martin Pacesa @martinpacesa.bsky.social · Aug 27

Exciting to see our protein binder design pipeline BindCraft published in its final form in @Nature ! This has been an amazing collaborative effort with Lennart, Christian, @sokrypton.org, Bruno and many other amazing lab members and collaborators.

www.nature.com/articles/s41...

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Tommaso Patriarchi @tpatriarchi.bsky.social · Jun 6

Amazing work by the Andermann Lab showcasing a perfect use-case for FLIM imaging of dopamine sensors - looking at tonic [DA] changes and adaptations over days! Honored to be part of this effort.

Praneel Sunkavalli @praneelsunkavalli.bsky.social · Jun 2

I am excited to share our preprint on how hypothalamic dopamine neurons govern slow changes in motivation over days! Below are our findings:

www.biorxiv.org/content/10.1...

Slow-Timescale Regulation of Dopamine Release and Mating Drive over Days

The rise and fall of motivational states may take place over timescales as long as many days. We used mouse mating behavior to model how the brain orchestrates slow-timescale changes in motivation. Ma...

www.biorxiv.org

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Reposted by Tommaso Patriarchi

Libby Whittemore @libbage55.bsky.social · Feb 24

#BlueskyResistance #Voices4Victory #ProudBlur
Advertisement at a London bus stop. Ya gotta love the British…

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Tommaso Patriarchi @tpatriarchi.bsky.social · Feb 23

www.nature.com/articles/s41...

This study is absolutely mind-blowing.

Topological segregation of stress sensors along the gut crypt–villus axis - Nature

Serotonergic enterochromaffin cells of the intestine exhibit distinct sensory, secretory and physiological properties depending on their location within the complex crypt–villus architecture of t...

www.nature.com

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Tommaso Patriarchi @tpatriarchi.bsky.social · Feb 20

Congratulations Tal!! It's so great to see this out, I am very happy for you and your lab!!

Tal Laviv @lavivtal.bsky.social · Feb 20

I started my lab more then 4 years ago, and we have endured some very challenging times ever since.…I am very excited to share the first paper from my lab, published now in @naturemethods.bsky.social
www.nature.com/articles/s41...

Genetically encoded biosensor for fluorescence lifetime imaging of PTEN dynamics in the intact brain - Nature Methods

A first-in-class fluorescence lifetime-based FRET sensor for phosphatase and tensin homolog (PTEN) enables the dynamic monitoring of PTEN activity in cultured cells and in vivo with high spatiotempora...

www.nature.com

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Tommaso Patriarchi @tpatriarchi.bsky.social · Feb 10

REQUIREMENTS:
• Master’s degree in Biotechnology, Biochemistry, Bioengineering, Molecular Biology or a
related discipline.
• good experience in (and/or): molecular cloning, mammalian cell culture, microscopy, FACS
• Good organizational skills, attention to details, reliability, and teamwork

Tommaso Patriarchi @tpatriarchi.bsky.social · Feb 10

Our lab has an open PhD student position in Protein Engineering - Neurotechnology. Apply if interested!

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Tommaso Patriarchi @tpatriarchi.bsky.social · Dec 18

Amazing work by @massecklab.bsky.social PinkyCaMP the first mScarlet based Ca2+ indicator! Congrats to all, proud to have contributed to this

Masseck Lab @massecklab.bsky.social · Dec 18

🎄PinkyCaMP- our christmas gift to you! 🎁: We are excited to present PinkyCaMP, the first mScarlet based calcium sensor with:
✨exceptional, brightness
✨phototability
✨and optogenetic compatability.
Check out our new preprint:
www.biorxiv.org/content/10.1...

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Tommaso Patriarchi @tpatriarchi.bsky.social · Dec 15

Thank you Tal!!

Tommaso Patriarchi @tpatriarchi.bsky.social · Dec 13

Extremely proud to see my second PhD student (now Dr.) Xuehan Zhou defending her thesis so brilliantly and successfully! Such happy moments :)

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Tommaso Patriarchi @tpatriarchi.bsky.social · Dec 13

Our lab is looking for a motivated Research Assistant with hands-on experience with molecular cloning techniques, mammalian cell culture and confocal imaging. If you are interested in joining or know anyone who is, please email me your application. Thanks

Tommaso Patriarchi @tpatriarchi.bsky.social · Dec 5

This is really fascinating work, congrats to the whole team!

Alice Ting @aliceyting.bsky.social · Dec 4

with the antagonist, leading to relief of receptor inhibition. Drug or agonist can then turn on PAGER.

www.nature.com/articles/s41...

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Reposted by Tommaso Patriarchi

Tim Behrens @behrenstimb.bsky.social · Dec 1

OK If we are moving to Bluesky I am rescuing my favourite ever twitter thread (Jan 2019).

The renamed:

Bluesky-sized history of neuroscience (biased by my interests)

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