Trever Greene
@trevergreene.bsky.social
Investigating how Dendritic Cells adapt their metabolism and function. | Unraveling the intricacies of the immune system. | Enjoying coffee, books, and learning to be a parent.
Excited to finally share this work! pDCs make more IFN than any other cell, but they stop when an infection lasts too long. Why is that? Turns out it’s because their metabolism is suppressed. Moreover, when we restore pDC function, it looks like this loss of function protects against colitis!
Metabolic Deficiencies Underlie Plasmacytoid Dendritic Cell Exhaustion After Viral Infection https://www.biorxiv.org/content/10.1101/2024.02.28.582551v1
Metabolic Deficiencies Underlie Plasmacytoid Dendritic Cell Exhaustion After Viral Infection https://www.biorxiv.org/content/10.1101/2024.02.28.582551v1
Type I Interferons (IFN-I) are central to host protection against viral infections. While any cell c
www.biorxiv.org
March 4, 2024 at 10:51 PM
Excited to finally share this work! pDCs make more IFN than any other cell, but they stop when an infection lasts too long. Why is that? Turns out it’s because their metabolism is suppressed. Moreover, when we restore pDC function, it looks like this loss of function protects against colitis!