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Nina Tsvetanova @tsvetanovalab.bsky.social · 4d

The lab had an excellent time at the annual Duke Pharmacology & Cancer Bio retreat! Katherine gave a great talk, and she and Matt each won a department award to recognize success in obtaining a fellowship and an impactful publication, respectively. 🎉

Nina Tsvetanova @tsvetanovalab.bsky.social · Aug 28

Functionally, these molecular changes translate into remodeled neuronal architecture:

➡️ Enhanced dendritic arborization
➡️ Synapse formation

This highlights a mechanism by which receptor trafficking can contribute to neuronal plasticity. Intracellular GPCRs for the win! 4/4

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Nina Tsvetanova @tsvetanovalab.bsky.social · Aug 28

We show that internalized receptors are not silent passengers: they remain active on endosomes and drive extensive neuronal gene expression rewiring through CREB-dependent transcription and mTOR-dependent translation. 3/4

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Nina Tsvetanova @tsvetanovalab.bsky.social · Aug 28

GPCRs are classically known for their signaling at the plasma membrane. But what happens after they internalize into endosomes? We asked how endocytosis of the β2-adrenergic receptor influences neuronal function. 2/4

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Nina Tsvetanova @tsvetanovalab.bsky.social · Aug 28

Our preprint “GPCR endocytosis rewires neuronal gene expression and cellular architecture” is now live on bioRxiv.
🔗 doi.org/10.1101/2025...

We uncover how GPCR trafficking shapes protein content and neuronal structure. Congratulations to our team members, Katherine Hall and Matt Klauer!

A short🧵

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Nina Tsvetanova @tsvetanovalab.bsky.social · Jul 2

📣 We are looking for a full-time research technician. This is a great opportunity for recent grads seeking additional hands-on experience before grad or med school. Join our team in exploring GPCR signaling and pharmacology at @dukemedschool.bsky.social Description: careers.duke.edu/job/Durham-R...

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Nina Tsvetanova @tsvetanovalab.bsky.social · Jun 26

Great science and stunning views of the Niagara Falls at the GRK and arrestin @faseborg.bsky.social meeting. Thanks to @sudarrajagopal.bsky.social @calebirolab.bsky.social @joann-trejo.bsky.social and Irene Coin for organizing an excellent conference and for the invitation. #GKASRC

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Nina Tsvetanova @tsvetanovalab.bsky.social · Jun 20

Congrats to our grad student Peter on successfully passing his prelim 🎉

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Nina Tsvetanova @tsvetanovalab.bsky.social · Jun 11

Celebrating all wins- big and small. Marking our new grant with a great evening of bowling and bonding with our collaborators, the Walsh lab at UNC!

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Reposted by Nina Tsvetanova

Nature Chemical Biology @natchembio.nature.com · Jun 3

A new Review highlights recent advances in understanding compartmentalized GPCR signaling using chemical biology approaches with a focus on tools for real-time monitoring, site-selective tuning of signaling protein networks and mechanistic screening

www.nature.com/articles/s41...

Chemical biology approaches to resolve the subcellular GPCR signaling landscape - Nature Chemical Biology

This Review highlights recent advances in understanding compartmentalized GPCR signaling using chemical biology approaches with a focus on tools for real-time monitoring, site-selective tuning of sign...

www.nature.com

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Nina Tsvetanova @tsvetanovalab.bsky.social · Jun 4

Check out our later take on GPCR signaling in space and time and the toolbox of chemogenetic and chemical biology approaches to explore this cool phenomenon ⬇️. I had a blast working with my colleagues @MiriamStoeber, @cyclic_Andreas and Braden Lobingier.

doi.org/10.1038/s415...

Chemical biology approaches to resolve the subcellular GPCR signaling landscape - Nature Chemical Biology

This Review highlights recent advances in understanding compartmentalized GPCR signaling using chemical biology approaches with a focus on tools for real-time monitoring, site-selective tuning of sign...

doi.org

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Nina Tsvetanova @tsvetanovalab.bsky.social · May 30

Congratulations to Malarie on passing her prelim exam with flying colors 🎉🍾

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Nina Tsvetanova @tsvetanovalab.bsky.social · Apr 24

Celebrating some exciting wins in the Tlab lately (grants awarded, papers accepted, new jobs, and experiments finally behaving) with 🍹🌮

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Nina Tsvetanova @tsvetanovalab.bsky.social · Apr 15

🎉 Thrilled to announce we have received the NoA for our new NIMH R01! Excited for the discoveries ahead and grateful to the NIH for the support.

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Nina Tsvetanova @tsvetanovalab.bsky.social · Apr 9

Congrats!

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Nina Tsvetanova @tsvetanovalab.bsky.social · Mar 27

Huge congratulations to Dr. Matt Klauer on a terrific PhD defense 🎊! Matt excelled consistently throughout his candidacy and has started a number of exciting new directions in the lab 🔬. We wish him all the best as he embarks on the next chapters of his scientific journey 👨🏻‍🎓🍾🎉

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Nina Tsvetanova @tsvetanovalab.bsky.social · Mar 12

Excellent news! Congratulations, Gavin.

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Nina Tsvetanova @tsvetanovalab.bsky.social · Feb 18

We used ribosome profiling to uncover a vast translational regulatory program controlled by a prototypical GPCR and second messenger. This is dependent on receptor compartmentalization and driven by spatially confined GPCR-dependent activation of #mTOR.

Nina Tsvetanova @tsvetanovalab.bsky.social · Feb 18

Excited to share the publication of our latest #NIH funded work led by Matt Klauer where we determine how #GPCRs shape the translational landscape of cells: www.pnas.org/doi/10.1073/...

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Nina Tsvetanova @tsvetanovalab.bsky.social · Feb 13

@bookmarkth.is; great question, I bet many of us I would love to know

Nina Tsvetanova @tsvetanovalab.bsky.social · Jan 28

Thank you, Karen!

Nina Tsvetanova @tsvetanovalab.bsky.social · Jan 27

Some much-needed good news 🎉: I am honored to receive the ASPET Molecular Pharmacology Division Early Career Award. Big thanks to Mikel Garcia-Marcos for the nomination. I am very grateful for the support and recognition by my colleagues at #ASPET and beyond.
ow.ly/nYiB50UNQLF

2025 Award Winners

ow.ly

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Nina Tsvetanova @tsvetanovalab.bsky.social · Jan 3

Excellent work @amanglik.bsky.social @willowcoyote.bsky.social and @justingenglish.bsky.social!!

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Nina Tsvetanova @tsvetanovalab.bsky.social · Dec 16

Congrats, Dan!!

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Nina Tsvetanova @tsvetanovalab.bsky.social · Dec 12

I am thrilled to congratulate Katherine Hall in the lab on being awarded an @americanheart.bsky.social predoctoral fellowship 🎉! Way to go!!

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