Nature Chemical Biology
@natchembio.nature.com
A scientific journal devoted to publishing the most compelling research, opinion and analysis at the intersection of chemistry and biology.
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Our January issue is live!
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The cover depicts a method for real-time monitoring of microenvironmental changes in protein substructures using site-specific integration of a noncanonical amino acid with a rotor-based fluorophore
www.nature.com/nchembio/vol...
The cover depicts a method for real-time monitoring of microenvironmental changes in protein substructures using site-specific integration of a noncanonical amino acid with a rotor-based fluorophore
January 13, 2026 at 8:50 PM
Structural basis for the catalytic mechanism of human lipid phosphate phosphatases
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January 13, 2026 at 8:48 PM
Structural basis for the catalytic mechanism of human lipid phosphate phosphatases
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Ubiquitin acts as a proteinaceous glue to fasten the intersubunit interaction within the Polycomb repressive deubiquitinase complex to allosterically enhance its activity
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January 13, 2026 at 8:47 PM
Ubiquitin acts as a proteinaceous glue to fasten the intersubunit interaction within the Polycomb repressive deubiquitinase complex to allosterically enhance its activity
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LipoID profiles lipid droplet interactions and identifies interorganelle regulators
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January 13, 2026 at 8:44 PM
LipoID profiles lipid droplet interactions and identifies interorganelle regulators
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RNA capped with dinucleoside polyphosphates has been recently discovered in bacteria and eukaryotes. A new paper provides a structural explanation of how dinucleoside polyphosphates initiate RNA transcription
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January 13, 2026 at 8:43 PM
RNA capped with dinucleoside polyphosphates has been recently discovered in bacteria and eukaryotes. A new paper provides a structural explanation of how dinucleoside polyphosphates initiate RNA transcription
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Activity-based protein profiling covalent small molecules that potentiate the activity of the METTL5:TRMT112 complex through binding to a complexoform-restricted allosteric pocket absent in other TRMT112:methyltransferase complexes
www.nature.com/articles/s41...
www.nature.com/articles/s41...
January 12, 2026 at 5:12 PM
Activity-based protein profiling covalent small molecules that potentiate the activity of the METTL5:TRMT112 complex through binding to a complexoform-restricted allosteric pocket absent in other TRMT112:methyltransferase complexes
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Reposted by Nature Chemical Biology
Short fatty acids, custom synthesized by engineered yeast 🧫
Here it is: doi.org/10.1038/s415...
🤝✨ Fantastic team effort — thanks to Yongjin Zhou!
Science made possible at @goetheuni.bsky.social 🏛️🔬
Here it is: doi.org/10.1038/s415...
🤝✨ Fantastic team effort — thanks to Yongjin Zhou!
Science made possible at @goetheuni.bsky.social 🏛️🔬
January 8, 2026 at 8:49 PM
Short fatty acids, custom synthesized by engineered yeast 🧫
Here it is: doi.org/10.1038/s415...
🤝✨ Fantastic team effort — thanks to Yongjin Zhou!
Science made possible at @goetheuni.bsky.social 🏛️🔬
Here it is: doi.org/10.1038/s415...
🤝✨ Fantastic team effort — thanks to Yongjin Zhou!
Science made possible at @goetheuni.bsky.social 🏛️🔬
Engineering polymerases to synthesize alternative genetic polymers remains a challenge. Using DNA shuffling and droplet microfluidics, this study provides a short evolutionary path from a DNA polymerase to one with robust RNA-synthesizing activity
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www.nature.com/articles/s41...
January 12, 2026 at 5:09 PM
Engineering polymerases to synthesize alternative genetic polymers remains a challenge. Using DNA shuffling and droplet microfluidics, this study provides a short evolutionary path from a DNA polymerase to one with robust RNA-synthesizing activity
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Glycosylation often functions to mediate protein folding, stability, and protein-protein interactions. Here, O-GlcNAcylation of histone H2B S112 allosterically activates E2 enzyme RAD6A and directly enhances its activity for H2B K120 monoubiquitylation
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www.nature.com/articles/s41...
January 12, 2026 at 4:57 PM
Glycosylation often functions to mediate protein folding, stability, and protein-protein interactions. Here, O-GlcNAcylation of histone H2B S112 allosterically activates E2 enzyme RAD6A and directly enhances its activity for H2B K120 monoubiquitylation
www.nature.com/articles/s41...
www.nature.com/articles/s41...
A new paper developed a photo-crosslinking platform to capture ligands from complex samples, identifying Little-LEN as a ligand for GPR50 which coordinately regulates body metabolism
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January 12, 2026 at 4:54 PM
A new paper developed a photo-crosslinking platform to capture ligands from complex samples, identifying Little-LEN as a ligand for GPR50 which coordinately regulates body metabolism
www.nature.com/articles/s41...
www.nature.com/articles/s41...
A new paper reports the upper S1-S4 pocket as a multifunctional regulatory hub for TRPM5. Its probing reveals the mechanism of communication between the transmembrane and intracellular domains in the modulation of TRPM5 activity
www.nature.com/articles/s41...
www.nature.com/articles/s41...
January 12, 2026 at 4:53 PM
A new paper reports the upper S1-S4 pocket as a multifunctional regulatory hub for TRPM5. Its probing reveals the mechanism of communication between the transmembrane and intracellular domains in the modulation of TRPM5 activity
www.nature.com/articles/s41...
www.nature.com/articles/s41...
A new paper reports on a synthetic yeast toolbox that programs cell-cell adhesion and cross-feeding, enabling spatial patterning coupled with division of labor, boosting high-value antioxidant resveratrol production
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www.nature.com/articles/s41...
January 12, 2026 at 4:50 PM
A new paper reports on a synthetic yeast toolbox that programs cell-cell adhesion and cross-feeding, enabling spatial patterning coupled with division of labor, boosting high-value antioxidant resveratrol production
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Cryo-EM structures of type-I and type-II Lamassu systems in apo and double-stranded DNA-bound states reveal the unique architecture and mechanisms of this prokaryotic antiphage system
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January 8, 2026 at 9:01 PM
Cryo-EM structures of type-I and type-II Lamassu systems in apo and double-stranded DNA-bound states reveal the unique architecture and mechanisms of this prokaryotic antiphage system
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Biopolymers can couple to membrane lipids and condense to prewet membranes. A new paper shows prewetting is sensitive to membrane composition and phase transitions and can drive interorganelle contact #lipidtime
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January 8, 2026 at 8:58 PM
Biopolymers can couple to membrane lipids and condense to prewet membranes. A new paper shows prewetting is sensitive to membrane composition and phase transitions and can drive interorganelle contact #lipidtime
www.nature.com/articles/s41...
www.nature.com/articles/s41...
A DNA nanoruler platform enables precise measurement of the labeling radii of TurboID and APEX2, uncovering their contact-dependent mechanisms
www.nature.com/articles/s41...
www.nature.com/articles/s41...
January 8, 2026 at 8:55 PM
A DNA nanoruler platform enables precise measurement of the labeling radii of TurboID and APEX2, uncovering their contact-dependent mechanisms
www.nature.com/articles/s41...
www.nature.com/articles/s41...
A new Perspective highlights advances in BRET technology for measuring intracellular drug-target engagement
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January 8, 2026 at 8:51 PM
A new Perspective highlights advances in BRET technology for measuring intracellular drug-target engagement
www.nature.com/articles/s41...
www.nature.com/articles/s41...
The enzyme PCMT1 was found to install a C-terminal cyclic imide modification on proteins that marks them for degradation by CRBN, uncovering a conserved protein turnover pathway with implications in metabolism and neurological function
www.nature.com/articles/s41...
www.nature.com/articles/s41...
January 8, 2026 at 8:49 PM
The enzyme PCMT1 was found to install a C-terminal cyclic imide modification on proteins that marks them for degradation by CRBN, uncovering a conserved protein turnover pathway with implications in metabolism and neurological function
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Our January issue is live!
www.nature.com/nchembio/vol...
The cover depicts a method for real-time monitoring of microenvironmental changes in protein substructures using site-specific integration of a noncanonical amino acid with a rotor-based fluorophore
www.nature.com/nchembio/vol...
The cover depicts a method for real-time monitoring of microenvironmental changes in protein substructures using site-specific integration of a noncanonical amino acid with a rotor-based fluorophore
January 8, 2026 at 4:38 PM
Our January issue is live!
www.nature.com/nchembio/vol...
The cover depicts a method for real-time monitoring of microenvironmental changes in protein substructures using site-specific integration of a noncanonical amino acid with a rotor-based fluorophore
www.nature.com/nchembio/vol...
The cover depicts a method for real-time monitoring of microenvironmental changes in protein substructures using site-specific integration of a noncanonical amino acid with a rotor-based fluorophore
Reposted by Nature Chemical Biology
Thrilled to share our latest study, led by @reikatei.bsky.social, in @natchembio.nature.com! We began by asking a simple question—how do cells know if they have too much of a lipid in a particular membrane, and how do they respond to rectify this imbalance?
www.nature.com/articles/s41...
More info 👇
www.nature.com/articles/s41...
More info 👇
Membrane editing with proximity labeling reveals regulators of lipid homeostasis - Nature Chemical Biology
Coupling an optogenetic lipid-modifying enzyme with proximity labeling reveals protein networks and mechanisms regulating lipid homeostasis in the membranes of target organelles.
www.nature.com
January 7, 2026 at 2:59 PM
Thrilled to share our latest study, led by @reikatei.bsky.social, in @natchembio.nature.com! We began by asking a simple question—how do cells know if they have too much of a lipid in a particular membrane, and how do they respond to rectify this imbalance?
www.nature.com/articles/s41...
More info 👇
www.nature.com/articles/s41...
More info 👇
A new paper developed a deep-learning-based de novo design strategy that enables simultaneous scaffolding of three distinct epitopes and demonstrates the potential of generative models for complex multisite protein engineering
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Accurate single-domain scaffolding of three nonoverlapping protein epitopes using deep learning - Nature Chemical Biology
A deep-learning-based de novo design strategy was developed that enables simultaneous scaffolding of three distinct epitopes derived from respiratory syncytial virus within small single-domain immunog...
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December 12, 2025 at 9:47 PM
A new paper developed a deep-learning-based de novo design strategy that enables simultaneous scaffolding of three distinct epitopes and demonstrates the potential of generative models for complex multisite protein engineering
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Come join our team! The deadline is December 7, but the application is quick. Only a cover letter, CV, and a short Research Highlight are needed #chemsky #chemjob #chembio
Job vacancy: Nature Chemical Biology is hiring
Nature Chemical Biology is seeking an Associate or Senior Editor. This is a permanent full-time position within the editorial team. The vacancy is for one of the offices based in USA or China.
springernature.wd3.myworkdayjobs.com/en-US/Spring...
Nature Chemical Biology is seeking an Associate or Senior Editor. This is a permanent full-time position within the editorial team. The vacancy is for one of the offices based in USA or China.
springernature.wd3.myworkdayjobs.com/en-US/Spring...
Associate or Senior Editor, Nature Chemical Biology
Job Title: Associate or Senior Editor, Nature Chemical Biology Organization: Nature Portfolio Location: New York, Washington DC, Jersey City, Beijing or Shanghai – Hybrid working Model Closing date: D...
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December 3, 2025 at 9:22 PM
Selinexor is a covalent inhibitor of the nuclear export receptor exportin 1 (XPO1). A new paper reveals that selinexor mediates XPO1 degradation through an allosteric molecular glue mechanism
www.nature.com/articles/s41...
www.nature.com/articles/s41...
SINE compounds activate exportin 1 degradation through an allosteric mechanism - Nature Chemical Biology
Selinexor is a covalent inhibitor of the nuclear export receptor exportin 1 (XPO1). Wing, Fung and Kwanten et al. found that selinexor mediates XPO1 degradation through an allosteric molecule glue mec...
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December 3, 2025 at 9:15 PM
Selinexor is a covalent inhibitor of the nuclear export receptor exportin 1 (XPO1). A new paper reveals that selinexor mediates XPO1 degradation through an allosteric molecular glue mechanism
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Radical Fe(II)/α-ketoglutarate-dependent halogenases are powerful biocatalysts for C-H functionalization. A new paper reveals the mechanistic basis for chemoselectivity in a lysine halogenase
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Dynamic metal coordination controls chemoselectivity in a radical halogenase - Nature Chemical Biology
Radical FeII/α-ketoglutarate-dependent halogenases are powerful biocatalysts for C–H functionalization. Here, the authors reveal the mechanistic basis for chemoselectivity in a lysine halogenase.
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December 3, 2025 at 9:09 PM
Radical Fe(II)/α-ketoglutarate-dependent halogenases are powerful biocatalysts for C-H functionalization. A new paper reveals the mechanistic basis for chemoselectivity in a lysine halogenase
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Molecular basis of SAM-AMP synthesis and degradation in the type III-B CRISPR-Cas system
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Molecular basis of SAM-AMP synthesis and degradation in the type III-B CRISPR–Cas system - Nature Chemical Biology
The CorA-associated type III-B CRISPR–Cas system synthesizes S-adenosyl methionine (SAM)-AMP, triggering immune responses. Through structural characterization and biochemical validation, Duan and Jin ...
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December 3, 2025 at 9:04 PM
Molecular basis of SAM-AMP synthesis and degradation in the type III-B CRISPR-Cas system
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Our December issue is live!
www.nature.com/nchembio/vol...
The cover depicts a diffusion-based generative deep learning pipeline for de novo design of a macrocyclic peptide targeting the protein, myeloid cell leukemia 1
www.nature.com/nchembio/vol...
The cover depicts a diffusion-based generative deep learning pipeline for de novo design of a macrocyclic peptide targeting the protein, myeloid cell leukemia 1
December 3, 2025 at 8:58 PM
Our December issue is live!
www.nature.com/nchembio/vol...
The cover depicts a diffusion-based generative deep learning pipeline for de novo design of a macrocyclic peptide targeting the protein, myeloid cell leukemia 1
www.nature.com/nchembio/vol...
The cover depicts a diffusion-based generative deep learning pipeline for de novo design of a macrocyclic peptide targeting the protein, myeloid cell leukemia 1