Nature Chemical Biology
@natchembio.nature.com
A scientific journal devoted to publishing the most compelling research, opinion and analysis at the intersection of chemistry and biology.
January 13, 2026 at 8:50 PM
Structural basis for the catalytic mechanism of human lipid phosphate phosphatases
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January 13, 2026 at 8:48 PM
Structural basis for the catalytic mechanism of human lipid phosphate phosphatases
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Ubiquitin acts as a proteinaceous glue to fasten the intersubunit interaction within the Polycomb repressive deubiquitinase complex to allosterically enhance its activity
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January 13, 2026 at 8:47 PM
Ubiquitin acts as a proteinaceous glue to fasten the intersubunit interaction within the Polycomb repressive deubiquitinase complex to allosterically enhance its activity
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LipoID profiles lipid droplet interactions and identifies interorganelle regulators
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January 13, 2026 at 8:44 PM
LipoID profiles lipid droplet interactions and identifies interorganelle regulators
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RNA capped with dinucleoside polyphosphates has been recently discovered in bacteria and eukaryotes. A new paper provides a structural explanation of how dinucleoside polyphosphates initiate RNA transcription
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January 13, 2026 at 8:43 PM
RNA capped with dinucleoside polyphosphates has been recently discovered in bacteria and eukaryotes. A new paper provides a structural explanation of how dinucleoside polyphosphates initiate RNA transcription
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Activity-based protein profiling covalent small molecules that potentiate the activity of the METTL5:TRMT112 complex through binding to a complexoform-restricted allosteric pocket absent in other TRMT112:methyltransferase complexes
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January 12, 2026 at 5:12 PM
Activity-based protein profiling covalent small molecules that potentiate the activity of the METTL5:TRMT112 complex through binding to a complexoform-restricted allosteric pocket absent in other TRMT112:methyltransferase complexes
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Engineering polymerases to synthesize alternative genetic polymers remains a challenge. Using DNA shuffling and droplet microfluidics, this study provides a short evolutionary path from a DNA polymerase to one with robust RNA-synthesizing activity
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January 12, 2026 at 5:09 PM
Engineering polymerases to synthesize alternative genetic polymers remains a challenge. Using DNA shuffling and droplet microfluidics, this study provides a short evolutionary path from a DNA polymerase to one with robust RNA-synthesizing activity
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Glycosylation often functions to mediate protein folding, stability, and protein-protein interactions. Here, O-GlcNAcylation of histone H2B S112 allosterically activates E2 enzyme RAD6A and directly enhances its activity for H2B K120 monoubiquitylation
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January 12, 2026 at 4:57 PM
Glycosylation often functions to mediate protein folding, stability, and protein-protein interactions. Here, O-GlcNAcylation of histone H2B S112 allosterically activates E2 enzyme RAD6A and directly enhances its activity for H2B K120 monoubiquitylation
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A new paper developed a photo-crosslinking platform to capture ligands from complex samples, identifying Little-LEN as a ligand for GPR50 which coordinately regulates body metabolism
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January 12, 2026 at 4:54 PM
A new paper developed a photo-crosslinking platform to capture ligands from complex samples, identifying Little-LEN as a ligand for GPR50 which coordinately regulates body metabolism
www.nature.com/articles/s41...
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A new paper reports the upper S1-S4 pocket as a multifunctional regulatory hub for TRPM5. Its probing reveals the mechanism of communication between the transmembrane and intracellular domains in the modulation of TRPM5 activity
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January 12, 2026 at 4:53 PM
A new paper reports the upper S1-S4 pocket as a multifunctional regulatory hub for TRPM5. Its probing reveals the mechanism of communication between the transmembrane and intracellular domains in the modulation of TRPM5 activity
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A new paper reports on a synthetic yeast toolbox that programs cell-cell adhesion and cross-feeding, enabling spatial patterning coupled with division of labor, boosting high-value antioxidant resveratrol production
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January 12, 2026 at 4:50 PM
A new paper reports on a synthetic yeast toolbox that programs cell-cell adhesion and cross-feeding, enabling spatial patterning coupled with division of labor, boosting high-value antioxidant resveratrol production
www.nature.com/articles/s41...
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Cryo-EM structures of type-I and type-II Lamassu systems in apo and double-stranded DNA-bound states reveal the unique architecture and mechanisms of this prokaryotic antiphage system
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January 8, 2026 at 9:01 PM
Cryo-EM structures of type-I and type-II Lamassu systems in apo and double-stranded DNA-bound states reveal the unique architecture and mechanisms of this prokaryotic antiphage system
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Biopolymers can couple to membrane lipids and condense to prewet membranes. A new paper shows prewetting is sensitive to membrane composition and phase transitions and can drive interorganelle contact #lipidtime
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January 8, 2026 at 8:58 PM
Biopolymers can couple to membrane lipids and condense to prewet membranes. A new paper shows prewetting is sensitive to membrane composition and phase transitions and can drive interorganelle contact #lipidtime
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A DNA nanoruler platform enables precise measurement of the labeling radii of TurboID and APEX2, uncovering their contact-dependent mechanisms
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January 8, 2026 at 8:55 PM
A DNA nanoruler platform enables precise measurement of the labeling radii of TurboID and APEX2, uncovering their contact-dependent mechanisms
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A new Perspective highlights advances in BRET technology for measuring intracellular drug-target engagement
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January 8, 2026 at 8:51 PM
A new Perspective highlights advances in BRET technology for measuring intracellular drug-target engagement
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The enzyme PCMT1 was found to install a C-terminal cyclic imide modification on proteins that marks them for degradation by CRBN, uncovering a conserved protein turnover pathway with implications in metabolism and neurological function
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January 8, 2026 at 8:49 PM
The enzyme PCMT1 was found to install a C-terminal cyclic imide modification on proteins that marks them for degradation by CRBN, uncovering a conserved protein turnover pathway with implications in metabolism and neurological function
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Our January issue is live!
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The cover depicts a method for real-time monitoring of microenvironmental changes in protein substructures using site-specific integration of a noncanonical amino acid with a rotor-based fluorophore
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The cover depicts a method for real-time monitoring of microenvironmental changes in protein substructures using site-specific integration of a noncanonical amino acid with a rotor-based fluorophore
January 8, 2026 at 4:38 PM
Our January issue is live!
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The cover depicts a method for real-time monitoring of microenvironmental changes in protein substructures using site-specific integration of a noncanonical amino acid with a rotor-based fluorophore
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The cover depicts a method for real-time monitoring of microenvironmental changes in protein substructures using site-specific integration of a noncanonical amino acid with a rotor-based fluorophore
Our December issue is live!
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The cover depicts a diffusion-based generative deep learning pipeline for de novo design of a macrocyclic peptide targeting the protein, myeloid cell leukemia 1
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The cover depicts a diffusion-based generative deep learning pipeline for de novo design of a macrocyclic peptide targeting the protein, myeloid cell leukemia 1
December 3, 2025 at 8:58 PM
Our December issue is live!
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The cover depicts a diffusion-based generative deep learning pipeline for de novo design of a macrocyclic peptide targeting the protein, myeloid cell leukemia 1
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The cover depicts a diffusion-based generative deep learning pipeline for de novo design of a macrocyclic peptide targeting the protein, myeloid cell leukemia 1
Our November issue is live!
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The cover depicts a SEM image of a dorsal surface of liverwort M. polymorpha female thallus. Liverwort were found to have a noncanonical pathway for the regulation of master growth repressor DELLA.
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The cover depicts a SEM image of a dorsal surface of liverwort M. polymorpha female thallus. Liverwort were found to have a noncanonical pathway for the regulation of master growth repressor DELLA.
October 31, 2025 at 2:00 PM
Our November issue is live!
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The cover depicts a SEM image of a dorsal surface of liverwort M. polymorpha female thallus. Liverwort were found to have a noncanonical pathway for the regulation of master growth repressor DELLA.
www.nature.com/nchembio/vol...
The cover depicts a SEM image of a dorsal surface of liverwort M. polymorpha female thallus. Liverwort were found to have a noncanonical pathway for the regulation of master growth repressor DELLA.
‘Pausing for stress’ – Check out the associated News & Views by Amy Strom on how MED1 acetylation tunes transcriptional condensates and RNA Pol II pausing during stress responses
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October 27, 2025 at 3:44 PM
‘Pausing for stress’ – Check out the associated News & Views by Amy Strom on how MED1 acetylation tunes transcriptional condensates and RNA Pol II pausing during stress responses
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Our October issue is live!
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The cover image depicts synergistic yeast consortia that mimic the collaborative interactions in plant multicellular systems, enabling the de novo biosynthesis of complex natural product lignans
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The cover image depicts synergistic yeast consortia that mimic the collaborative interactions in plant multicellular systems, enabling the de novo biosynthesis of complex natural product lignans
September 29, 2025 at 3:58 PM
Our October issue is live!
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The cover image depicts synergistic yeast consortia that mimic the collaborative interactions in plant multicellular systems, enabling the de novo biosynthesis of complex natural product lignans
www.nature.com/nchembio/vol...
The cover image depicts synergistic yeast consortia that mimic the collaborative interactions in plant multicellular systems, enabling the de novo biosynthesis of complex natural product lignans
Our September issue is live!
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The cover image depicts translocation of synthetic condensates and DNA and RNA, facilitated by engineered DNA- and RNA-binding proteins, from the cytoplasm to the nucleus in the presence of small molecules.
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The cover image depicts translocation of synthetic condensates and DNA and RNA, facilitated by engineered DNA- and RNA-binding proteins, from the cytoplasm to the nucleus in the presence of small molecules.
August 28, 2025 at 7:21 PM
Our September issue is live!
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The cover image depicts translocation of synthetic condensates and DNA and RNA, facilitated by engineered DNA- and RNA-binding proteins, from the cytoplasm to the nucleus in the presence of small molecules.
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The cover image depicts translocation of synthetic condensates and DNA and RNA, facilitated by engineered DNA- and RNA-binding proteins, from the cytoplasm to the nucleus in the presence of small molecules.
The 21st annual Tri-Institutional Chemical Biology Symposium will be held on Thursday, August 28, 2025, 9:00 am – 6:00 pm, on the campus of Memorial Sloan Kettering Cancer Center. Registration will close on Wednesday, August 20.
August 19, 2025 at 6:51 AM
The 21st annual Tri-Institutional Chemical Biology Symposium will be held on Thursday, August 28, 2025, 9:00 am – 6:00 pm, on the campus of Memorial Sloan Kettering Cancer Center. Registration will close on Wednesday, August 20.
Our August issue is live!
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The cover image depicts a phage-defense system TdpABC, wherein a phosphorothioate (PT) modification is made to bacterial DNA by TdpC and the invading PT-free phage DNA is degraded by the TdpAB complex
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The cover image depicts a phage-defense system TdpABC, wherein a phosphorothioate (PT) modification is made to bacterial DNA by TdpC and the invading PT-free phage DNA is degraded by the TdpAB complex
July 30, 2025 at 3:06 PM
Our August issue is live!
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The cover image depicts a phage-defense system TdpABC, wherein a phosphorothioate (PT) modification is made to bacterial DNA by TdpC and the invading PT-free phage DNA is degraded by the TdpAB complex
www.nature.com/nchembio/vol...
The cover image depicts a phage-defense system TdpABC, wherein a phosphorothioate (PT) modification is made to bacterial DNA by TdpC and the invading PT-free phage DNA is degraded by the TdpAB complex
Our July issue is live!
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The cover image depicts a target protein bound to a high-affinity aptamer that gets enriched after a single selection round with multiple elution steps.
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The cover image depicts a target protein bound to a high-affinity aptamer that gets enriched after a single selection round with multiple elution steps.
June 27, 2025 at 1:59 PM
Our July issue is live!
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The cover image depicts a target protein bound to a high-affinity aptamer that gets enriched after a single selection round with multiple elution steps.
www.nature.com/nchembio/vol...
The cover image depicts a target protein bound to a high-affinity aptamer that gets enriched after a single selection round with multiple elution steps.