Lightnews — Scholar-powered news

Twist Bioscience @twistbioscience.com · 21h

“Biothreat hunters catch dangerous DNA before it gets made.”

We are super proud to be part of this red team effort with @erichorvitz.bsky.social & @msftresearch.bsky.social.

@silverjacket.bsky.social, @ibbis-bio.bsky.social, @jaimeyassif.bsky.social, @twistbioscience.com

Biothreat hunters catch dangerous DNA before it gets made

Microsoft researchers found a biological zero-day vulnerability — and created a software patch.

www.nature.com

1

Twist Bioscience @twistbioscience.com · 1d

Red-team testing is critical in strengthening biosecurity and we’re proud to be at the forefront of this work with such a great team!

@twistbioscience.com
@jdiggans.bsky.social

Microsoft Research @msftresearch.bsky.social · 1d

In “Ideas,” collaborators Eric Horvitz, Bruce Wittmann, Tessa Alexanian, & James Diggans discuss a red-teaming effort that exposed & secured a biosecurity vulnerability in AI-driven protein design—& what the work shows about managing AI’s dual-use risks. msft.it/6010sLYsr

Twist Bioscience @twistbioscience.com · 1d

Twist Bioscience’s high-throughput DNA synthesis platform is enabling AI researchers to compress protein discovery timelines and expand therapeutic possibilities.

👉 www.asianscientist.com/2025/10/spon...

@twistbioscience.com

2

Twist Bioscience @twistbioscience.com · 2d

New product announcement! Today we’re launching 🚀 Twist’s new Trinity Freestyle Fast Hybridization workflow for Element's AVITI™.

Go from sample to sequencer in as little as five hours.

Learn more here: investors.twistbioscience.com/news-release...

@twistbioscience.com, @elembio.bsky.social

Reposted by Twist Bioscience

Element Biosciences @elembio.bsky.social · 2d

📢 Alongside @twistbioscience.com, we’re excited to launch the Trinity Freestyle™ Fast Hybridization workflow for our #AVITI! This end-to-end #sequencing solution enables researchers to go from sample to sequencer in as little as five hours. Learn more here: https://bit.ly/4gYq2jo

Twist Bioscience and Element Biosciences Advance Collaboration with Launch of New Trinity Freestyle Sequencing Workflow for the AVITI System

Twist’s Trinity Freestyle Fast Hybridization workflow for AVITI is a user-friendly, end-to-end solution that combines speed, scalability, and flexibility.

bit.ly

1 1

Reposted by Twist Bioscience

Tina Han @tingfordha.bsky.social · 2d

Look forward to seeing everyone at #ASHG25! Our poster will showcase how we can bring exome sequencing to the next level -

Board 8011F: Utilization of Twist CNV Backbone Spike-in Panel with exome for replacing cytogenetic arrays

Stop by @twistbioscience.com booth #559 for more info

1 4

Twist Bioscience @twistbioscience.com · 5d

Blogs: www.twistbioscience.com/blog?topic=6...

Twist tools for cancer researchers: www.twistbioscience.com/applications...

Cancer Research eBook: www.twistbioscience.com/applications...

@twistbioscience.com

Blog | Twist Bioscience

Stories from biotech's leading edge

www.twistbioscience.com

1

Twist Bioscience @twistbioscience.com · 5d

Webinar: “Precision with a Purpose: Benchmark 659 for Cancer Care” discusses how target enrichment equips oncologists and pathologists with insightful genomic data: www.twistbioscience.com/resources/we...

Precision with a Purpose: Benchmark 659 for Cancer Care - Powered by Twist Bioscience | Twist Bioscience

www.twistbioscience.com

1

Twist Bioscience @twistbioscience.com · 5d

Case Study: “Detecting Cancer’s Methylation Fingerprint in Blood Plasma” is available here: www.twistbioscience.com/resources/ca...

Detecting Cancer’s Methylation Fingerprint in Blood Plasma | Twist Bioscience

www.twistbioscience.com

1

Twist Bioscience @twistbioscience.com · 5d

October is #CancerAwarenessMonth, a time to honor the patients, families, advocates, and researchers who are rewriting what’s possible.

We’ve curated some of our relevant resources below 👇

1

Twist Bioscience @twistbioscience.com · 6d

“Strengthening nucleic acid biosecurity screening against generative protein design tools.”

Read the press release here: investors.twistbioscience.com/news-release...

Read the paper here: www.science.org/doi/10.1126/...

@twistbioscience.com, @msftresearch.bsky.social, @erichorvitz.bsky.social

Strengthening nucleic acid biosecurity screening against generative protein design tools

Advances in artificial intelligence (AI)–assisted protein engineering are enabling breakthroughs in the life sciences but also introduce new biosecurity challenges. Synthesis of nucleic acids is a cho...

www.science.org

1

Twist Bioscience @twistbioscience.com · 6d

🎉 Announcing our publication, now out in Science!

Led by Microsoft & co-authored with a consortium of scientific & industry experts including the IGSC, we examining biosecurity screening practices in AI-assisted protein design…

1

Twist Bioscience @twistbioscience.com · 6d

🩸 Steve Mack, Henry Erlich, and team chose a Twist custom panel for non-invasive testing of cfDNA in blood for neonatal testing for blood disorders: pmc.ncbi.nlm.nih.gov/articles/PMC...

Non-invasive prenatal testing of beta-hemoglobinopathies using next generation sequencing, in-silico sequence size selection, and haplotyping

To develop a non-invasive prenatal test for beta-hemoglobinopathies based on analyzing maternal plasma by using next generation sequencing. We applied next generation sequencing (NGS) of maternal plas...

pmc.ncbi.nlm.nih.gov

Twist Bioscience @twistbioscience.com · 6d

🧬 Researchers from Keio University School of Medicine used Twist Exome 2.0 and RNA Exome together to detect variants and uncover how mRNA decay escape works.
Read “ARID1A gene variants and fetal hydrocephalus: First evidence of mRNA decay escape” here:
www.sciencedirect.com/science/arti...

ARID1A gene variants and fetal hydrocephalus: First evidence of mRNA decay escape

Germline variants in ARID1A have been associated with the so-called BAFopathies, including Coffin-Siris syndrome, which is characterized by hypertrich…

www.sciencedirect.com

1 1

Twist Bioscience @twistbioscience.com · 6d

🤖 New groundbreaking research from @brianhie.bsky.social, Samuel King, and team, leverages genomic foundation models like Evo2 to generate viable bacteriophage genomes, pushing the boundaries of synthesis at scale combined with GenAI, powered by Twist DNA: www.biorxiv.org/content/10.1...

Generative design of novel bacteriophages with genome language models

Many important biological functions arise not from single genes, but from complex interactions encoded by entire genomes. Genome language models have emerged as a promising strategy for designing biol...

www.biorxiv.org

1

Twist Bioscience @twistbioscience.com · 6d

🌉 Patrick Hsu’s Lab reports the discovery and engineering of the bridge recombinase ortholog ISCro4 for universal rearrangements of the human genome.
www.science.org/doi/10.1126/...

Megabase-scale human genome rearrangement with programmable bridge recombinases

Bridge recombinases are naturally occurring RNA-guided DNA recombinases that we previously demonstrated can programmably insert, excise, and invert DNA in vitro and in Escherichia coli. In this study,...

www.science.org

1

Twist Bioscience @twistbioscience.com · 6d

Customer spotlight! We’ve rounded up some of the hardest hitting science for your reading pleasure. Take a look…

1

Twist Bioscience @twistbioscience.com · 7d

Hoa, Angela, Alex and Ketan having a great time at #FestivalofBiologics! Come say 👋

@twistbioscience.com

1

Twist Bioscience @twistbioscience.com · 7d

Go ahead and zoom in on that slide!

We hosted an exclusive lunch and learn with New Haven pizza at Yale recently. Our talk kicking off cancer awareness month: Advancing Cancer Research with @twistbioscience.com focused on our new Oncology DNA CGP Panel.

Thank you to @yalecancer.bsky.social

Twist Bioscience @twistbioscience.com · 8d

What are you doing tomorrow? Joining us for a webinar hopefully: “Advancing Cancer Research with Next-Generation Sequencing: Custom Panels, Liquid Biopsy, and Methylation Profiling”

RSVP: www.labroots.com/webinar/adva...

#LRcancer

Twist Bioscience @twistbioscience.com · 8d

Now on demand!

For a deep dive into how next-generation perturbation datasets are enabling more predictive AI in biology, watch now: www.technologynetworks.com/tn/webinars/...

Twist Bioscience @twistbioscience.com · 9d

September highlights are here- the best of the best news from Twist:

We've rounded up the top news that happened this month including the new and very cool AI paper from Brian Hie's lab, our NGS grant winners, bioengineering plastics, and long read panels for primary care.
@twistbioscience.com

Base Pair Bulletin

Twist Bioscience News from September 2025 about NGS, AI, synthetic genomes, DNA, biosecurity, synthetic biology, biopharma, and more

www.linkedin.com

Twist Bioscience @twistbioscience.com · 12d

If you like this kind of content, we think you'll love our upcoming webinar on October 8th with @elembio.bsky.social! Learn more and RSVP here: event.on24.com/wcc/r/507032...

Twist Bioscience @twistbioscience.com · 12d

What's happening in high-throughput agrigenomics right now?

Get an inside look at the tools and techniques transforming agrigenomics with Josh Clevenger, from the Hudson Alpha Institute for Biotechnology: www.twistbioscience.com/resources/we...

1

Twist Bioscience @twistbioscience.com · 13d

Why settle for limited sequence space when you could screen everything?
Multiplexed Gene Fragments remove complexity barriers so you can design, build, and test like never before
✅ More variants
✅ More precision
✅ Less cost

👉 Explore the full potential here: www.twistbioscience.com/products/gen...