Tomek Wlodarski
@twlodarski.bsky.social
POLONEZ BIS Research Fellow in the Institute of Biochemistry and Biophysics PAS || Previously @UCL @Cambridge || @EMBO Fellow || Computational biophysicist || Protein folding on the ribosome || hiking/running || https://tomekwlodarski.com/
Just in time for 2026! 🎆 Presenting a nascent-centric view on the shape of the ribosomal exit tunnel topology, based on MD-derived occupancy maps for 55 distinct ribosomes. 🧶🧬🖥️
📄 Read the preprint: biorxiv.org/content/10.6...
#StructuralBiology #Ribosome #CryoEM #Evolution #Biophysics
📄 Read the preprint: biorxiv.org/content/10.6...
#StructuralBiology #Ribosome #CryoEM #Evolution #Biophysics
Evolution of the ribosomal exit tunnel through the eyes of the nascent chain
The ribosomal exit tunnel is a universally conserved feature of the large subunit that directs the nascent polypeptide chain into the cellular environment and is involved in co-translational folding, ...
biorxiv.org
December 30, 2025 at 10:30 PM
Just in time for 2026! 🎆 Presenting a nascent-centric view on the shape of the ribosomal exit tunnel topology, based on MD-derived occupancy maps for 55 distinct ribosomes. 🧶🧬🖥️
📄 Read the preprint: biorxiv.org/content/10.6...
#StructuralBiology #Ribosome #CryoEM #Evolution #Biophysics
📄 Read the preprint: biorxiv.org/content/10.6...
#StructuralBiology #Ribosome #CryoEM #Evolution #Biophysics
Reposted by Tomek Wlodarski
In press!! NMR & MD simulations reveal how non-native contacts stabilise a key transient intermediate in the lysozyme amyloid cascade. Well done Minkoo and all!! @phar.cam.ac.uk For CMD ❤️ advanced.onlinelibrary.wiley.com/doi/10.1002/...
Amyloid Forming Human Lysozyme Intermediates are Stabilized by Non‐Native Amide‐π Interactions
Mutational variants of human lysozyme cause fatal systemic amyloidosis by depositing kilograms of protein in the viscera of patients. Central to this process is a partially unfolded protein intermedi....
advanced.onlinelibrary.wiley.com
June 25, 2025 at 11:32 AM
In press!! NMR & MD simulations reveal how non-native contacts stabilise a key transient intermediate in the lysozyme amyloid cascade. Well done Minkoo and all!! @phar.cam.ac.uk For CMD ❤️ advanced.onlinelibrary.wiley.com/doi/10.1002/...
Reposted by Tomek Wlodarski
Preprint! All-atom structures of 2 folding intermediates on the ribosome, along parallel pathways & conserved across Ig domains, by 19F NMR & MD
Co-led by @julianstreit.bsky.social, & thanks twlodarski.bsky.social, Alki, Lisa & John Christodoulou!
#nmrchat #compbio
www.biorxiv.org/content/10.1...
Co-led by @julianstreit.bsky.social, & thanks twlodarski.bsky.social, Alki, Lisa & John Christodoulou!
#nmrchat #compbio
www.biorxiv.org/content/10.1...
Structures of protein folding intermediates on the ribosome
The ribosome biases the conformations sampled by nascent polypeptide chains along folding pathways towards biologically active states. A hallmark of the co-translational folding (coTF) of many protein...
www.biorxiv.org
April 11, 2025 at 7:45 PM
Preprint! All-atom structures of 2 folding intermediates on the ribosome, along parallel pathways & conserved across Ig domains, by 19F NMR & MD
Co-led by @julianstreit.bsky.social, & thanks twlodarski.bsky.social, Alki, Lisa & John Christodoulou!
#nmrchat #compbio
www.biorxiv.org/content/10.1...
Co-led by @julianstreit.bsky.social, & thanks twlodarski.bsky.social, Alki, Lisa & John Christodoulou!
#nmrchat #compbio
www.biorxiv.org/content/10.1...
Reposted by Tomek Wlodarski
We’re looking for fellow nerds to help us make disordered proteins druggable. Love #IDPs, #MD, #NMR, #AI, #DrugDiscovery, or #MassSpec? Let’s talk.
@bindresearch.org is hiring across the board: bindresearch.org/careers/
#compchem #compbio #NMRChat #TeamMassSpec #chemjobs @chemjobber.bsky.social
@bindresearch.org is hiring across the board: bindresearch.org/careers/
#compchem #compbio #NMRChat #TeamMassSpec #chemjobs @chemjobber.bsky.social
Careers
Careers
bindresearch.org
March 24, 2025 at 10:51 AM
We’re looking for fellow nerds to help us make disordered proteins druggable. Love #IDPs, #MD, #NMR, #AI, #DrugDiscovery, or #MassSpec? Let’s talk.
@bindresearch.org is hiring across the board: bindresearch.org/careers/
#compchem #compbio #NMRChat #TeamMassSpec #chemjobs @chemjobber.bsky.social
@bindresearch.org is hiring across the board: bindresearch.org/careers/
#compchem #compbio #NMRChat #TeamMassSpec #chemjobs @chemjobber.bsky.social