Tycho Mevissen
@tychomevissen.bsky.social
Postdoc in Johannes Walter's lab at Harvard Medical School. Interested in transcription, DNA repair, and ubiquitin. Formerly @MRC_LMB in David Komander's lab.
Pinned
Tycho Mevissen
@tychomevissen.bsky.social
· Nov 14
STK19 positions TFIIH for cell-free transcription-coupled DNA repair
Together with structural analyses, a cell-free system for transcription-coupled nucleotide
excision repair (TC-NER) shows that STK19 is an integral component of the TC-NER complex
that couples RNA pol...
cell.com
Let's get this site started. I'm excited to share that our work on transcription-coupled DNA repair is now published! We recapitulated TC-NER in Xenopus egg extract and identified STK19 as a core repair factor that couples lesion-stalled RNA Pol II to TFIIH. 🧬🐸
➡️ cell.com/cell/fulltex...
➡️ cell.com/cell/fulltex...
Reposted by Tycho Mevissen
Thrilled to share that the final piece of my PhD work is now on bioRxiv! biorxiv.org/content/10.1... With support from @nvidia and the @NSF, we used AlphaFold to screen 1.6M+ protein pairs, revealing thousands of potential novel PPIs. All data can be viewed at predictomes.org/hp
Proteome-wide in silico screening for human protein-protein interactions
Protein-protein interactions (PPIs) drive virtually all biological processes, yet most PPIs have not been identified and even more remain structurally unresolved. We developed a two-step computational...
biorxiv.org
November 12, 2025 at 9:26 PM
Thrilled to share that the final piece of my PhD work is now on bioRxiv! biorxiv.org/content/10.1... With support from @nvidia and the @NSF, we used AlphaFold to screen 1.6M+ protein pairs, revealing thousands of potential novel PPIs. All data can be viewed at predictomes.org/hp
Reposted by Tycho Mevissen
🧬 Transcription elongation by RNA polymerase II relies on a web of elongation factors. Our new work shows how IWS1 acts as a modular scaffold to stabilize & stimulate elongation. Fantastic work by Della Syau! www.biorxiv.org/content/10.1...
August 29, 2025 at 10:14 AM
🧬 Transcription elongation by RNA polymerase II relies on a web of elongation factors. Our new work shows how IWS1 acts as a modular scaffold to stabilize & stimulate elongation. Fantastic work by Della Syau! www.biorxiv.org/content/10.1...
Reposted by Tycho Mevissen
STK19
Transcription coupled repair
With TFIIH
#ChromatinHaiku
www.cell.com/cell/fulltex...
www.cell.com/cell/fulltex...
www.cell.com/molecular-ce...
Transcription coupled repair
With TFIIH
#ChromatinHaiku
www.cell.com/cell/fulltex...
www.cell.com/cell/fulltex...
www.cell.com/molecular-ce...
November 15, 2024 at 2:46 PM
STK19
Transcription coupled repair
With TFIIH
#ChromatinHaiku
www.cell.com/cell/fulltex...
www.cell.com/cell/fulltex...
www.cell.com/molecular-ce...
Transcription coupled repair
With TFIIH
#ChromatinHaiku
www.cell.com/cell/fulltex...
www.cell.com/cell/fulltex...
www.cell.com/molecular-ce...
Let's get this site started. I'm excited to share that our work on transcription-coupled DNA repair is now published! We recapitulated TC-NER in Xenopus egg extract and identified STK19 as a core repair factor that couples lesion-stalled RNA Pol II to TFIIH. 🧬🐸
➡️ cell.com/cell/fulltex...
➡️ cell.com/cell/fulltex...
STK19 positions TFIIH for cell-free transcription-coupled DNA repair
Together with structural analyses, a cell-free system for transcription-coupled nucleotide
excision repair (TC-NER) shows that STK19 is an integral component of the TC-NER complex
that couples RNA pol...
cell.com
November 14, 2024 at 4:18 PM
Let's get this site started. I'm excited to share that our work on transcription-coupled DNA repair is now published! We recapitulated TC-NER in Xenopus egg extract and identified STK19 as a core repair factor that couples lesion-stalled RNA Pol II to TFIIH. 🧬🐸
➡️ cell.com/cell/fulltex...
➡️ cell.com/cell/fulltex...