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Tyler Ekins

@tylerekins.bsky.social

640 followers 360 following 20 posts

(Psychedelic) neurophysiology researcher (postdoc) at University of Michigan (https://www.omarlab.org)

www.omarlab.org)

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Tyler Ekins @tylerekins.bsky.social · 22d

Excited to share our latest publication -- psychedelic drugs can enhance synaptic connectivity of neurons not expressing 5-HT2ARs (but requiring 5-HT2AR expression in the input neurons -- lots in the supplementals too!)

www.nature.com/articles/s41...

Psychedelic neuroplasticity of cortical neurons lacking 5-HT2A receptors - Molecular Psychiatry

Molecular Psychiatry - Psychedelic neuroplasticity of cortical neurons lacking 5-HT2A receptors

www.nature.com

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Tyler Ekins @tylerekins.bsky.social · 21d

Thank you!

Tyler Ekins @tylerekins.bsky.social · 22d

Psychedelic neuroplasticity of cortical neurons lacking 5-HT2A receptors - Molecular Psychiatry

Molecular Psychiatry - Psychedelic neuroplasticity of cortical neurons lacking 5-HT2A receptors

www.nature.com

7 19

Tyler Ekins @tylerekins.bsky.social · Sep 8

Got mine too -- thank you @cllantz.bsky.social !

Tyler Ekins @tylerekins.bsky.social · Aug 30

Much better 🤨

Tyler Ekins @tylerekins.bsky.social · Aug 13

Our latest manuscript (from www.omarlab.org) is now published and available online --
Long lasting enhancement in reversal learning after a single psychedelic dose

pmc.ncbi.nlm.nih.gov/articles/PMC...

Single-dose psychedelic enhances cognitive flexibility and reversal learning in mice weeks after administration

Psychedelic compounds have demonstrated remarkable therapeutic potential for treating neuropsychiatric disorders by promoting sustained neuroplasticity in the prefrontal cortex (PFC). Cognitive flexib...

pmc.ncbi.nlm.nih.gov

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Reposted by Tyler Ekins

CL @cllantz.bsky.social · Jul 20

Did you go to #GRCpsychedelics and not get soap? Don't worry, our themed soap will be ready in 2-3 weeks. Mouse brain toppers, rainbow swirl, dendrite+spine embed. Happy to send a free bar to ~10 people/ attendees.

These are handmade by an amateur, so expect imperfections.

Set a rainbow swirl cold process soap on a railing

A blue gloved hand holding a rainbow swirl bar of cold process soap.

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Tyler Ekins @tylerekins.bsky.social · Jul 20

Thank you so much!!

Tyler Ekins @tylerekins.bsky.social · Jul 20

Incredible! If any are still available i would
love one too!

1 1

Reposted by Tyler Ekins

Alaina Jaster, PhD @jasteralaina.bsky.social · Jul 18

Somehow we got almost all the students and postdocs in one photo!!

Until next time #GRCPsychedelics 🫡

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Reposted by Tyler Ekins

Alaina Jaster, PhD @jasteralaina.bsky.social · Jul 18

#GRCPsychedelics is squad goals !!

I learned so much, laughed even more, and slept even less

Grateful for the new connections, strengthening of old ones and for the opportunity to view my favorite topics from a different lens.

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Reposted by Tyler Ekins

Alex Kwan @alexkwan.bsky.social · Jul 8

A starter pack including all attendees (that I can find for now)

Please let me know if I missed anyone!

#GRCPsychedelics

go.bsky.app/2ExXJcr

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Tyler Ekins @tylerekins.bsky.social · May 1

Also interesting that insula is loaded with Htr2a!

Reposted by Tyler Ekins

Alex Kwan @alexkwan.bsky.social · Apr 10

Awhile back we started a Slack group for psychedelic science.

Researchers used it to organize meetups and panels at conferences. We discuss papers, including a lively discussion now of the Lu et al. preprint.

DM @mikaelpalner.bsky.social or I if you work in academia and want to join

An AI generated image of a psychedelic slack discussion group

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Reposted by Tyler Ekins

Alex Kwan @alexkwan.bsky.social · Apr 2

Our latest study identifies a specific cell type and receptor essential for psilocybin’s long-lasting neural and behavioral effects 🍄🔬🧠🧪

Led by Ling-Xiao Shao and @ItsClaraLiao

Funded by @NIH @NIMHgov

📄 Read in @nature.com - www.nature.com/articles/s41...

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Psilocybin’s lasting action requires pyramidal cell types and 5-HT2A receptors - Nature

A pyramidal cell type and the 5-HT2A receptor in the medial frontal cortex have essential roles in psilocybin’s long-term drug action.

www.nature.com

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Tyler Ekins @tylerekins.bsky.social · Feb 27

Congratulations!

Tyler Ekins @tylerekins.bsky.social · Jan 21

not quite the same!

Tyler Ekins @tylerekins.bsky.social · Jan 19

nice! looking forward to reading this

Tyler Ekins @tylerekins.bsky.social · Jan 8

Our latest preprint -- a single psychedelic dose induces a long-lasting improvement in reversal learning ability

www.biorxiv.org/content/10.1...

Psychedelic enhancement of flexible learning weeks after a single dose

Psychedelic drugs have shown therapeutic potential for the treatment of multiple neuropsychiatric disorders chiefly by promoting long-lasting plasticity in the prefrontal cortex (PFC). A critical func...

www.biorxiv.org

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Reposted by Tyler Ekins

Alex Kwan @alexkwan.bsky.social · Jan 6

Our latest work led by @claraliao.bsky.social is a collaboration with the other Kwan lab @kwanlab.bsky.social

We used single-nucleus RNA sequencing to measure transcriptional responses in the mouse medial frontal cortex following a single dose of psilocybin. 🍄 🧠 🧬

www.biorxiv.org/content/10.1...

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Tyler Ekins @tylerekins.bsky.social · Dec 27

many books!

Tyler Ekins @tylerekins.bsky.social · Dec 17

really interesting paper!

Reposted by Tyler Ekins

Seán Froudist-Walsh @seanfw.bsky.social · Dec 17

Psilocybin slows and reduces complexity of neural dynamics in medial prefrontal cortex.

New paper with Ross Purple, Rahul Gupta, Matt Jones & Co.

bioRxiv Neuroscience @biorxiv-neursci.bsky.social · Dec 14

Short- and long-term reconfiguration of rat prefrontal cortical networks following single doses of psilocybin https://www.biorxiv.org/content/10.1101/2024.12.10.627734v1

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Tyler Ekins @tylerekins.bsky.social · Dec 15

Mathematica, A Secret World of Intuition and Curiosity
yalebooks.yale.edu/book/9780300...

and

Poisoner in Chief
us.macmillan.com/books/978125...

Mathematica

A fascinating look into how the transformative joys of mathematical experience are available to everyone, not just specialists Math has a reputation for ...

yalebooks.yale.edu

Reposted by Tyler Ekins

bioRxiv Neuroscience @biorxiv-neursci.bsky.social · Dec 14

Short- and long-term reconfiguration of rat prefrontal cortical networks following single doses of psilocybin https://www.biorxiv.org/content/10.1101/2024.12.10.627734v1

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Tyler Ekins @tylerekins.bsky.social · Dec 12

Great work!