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These Patients Got the Cure. Then It Went Away.

UCLA Broad Stem Cell Research Center @uclastemcell.bsky.social · 5d

Our center director, Dr. Thomas Rando, is among the 13 distinguished researchers who have joined the Stem Cell Reports Editorial Board! 📖

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UCLA Broad Stem Cell Research Center @uclastemcell.bsky.social · 6d

After decades developing a proven gene therapy for ADA-SCID,
UCLA's Dr. Donald Kohn talks to @nytimes.com about his new mission: getting the life-saving therapy to the patients and families who've been waiting years. #ResearchPowersProgress

www.nytimes.com/2025/09/22/h...

www.nytimes.com

UCLA Broad Stem Cell Research Center @uclastemcell.bsky.social · 8d

UCLA scientists have received $4.7 million in @cirmnews.bsky.social grants to advance stem cell-based treatments for female-specific diseases and childhood leukemia in Down syndrome.

Congratulations to Dr. Kathrin Plath and Dr. Hanna Mikkola!

bit.ly/42ekrPN

#ResearchPowersProgress

UCLA scientists receive $4.7 million in CIRM grants to advance novel stem cell-based treatments for female-specific diseases and leukemia in Down syndrome

Researchers at the Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research at UCLA have received $4.7 million in grants from the California Institute for Regenerative Medicine, the...

UCLA Broad Stem Cell Research Center @uclastemcell.bsky.social · 12d

Join us on Thursday, October 2 as Dr. Alex Shcheglovitov of the University of Utah presents, "Neural rosette-based brain organoids: A controlled stem cell-derived model to study human neurodevelopment and disease” at 12pm in CHS 13-105.

Register today: ➡️ bit.ly/3W7cXKK

Headspace invaders: How mosquito-borne viruses breach the brain’s defenses

UCLA Broad Stem Cell Research Center @uclastemcell.bsky.social · 13d

A UCLA study from the lab of Melody Li reveals how some mosquito-borne viruses, including chikungunya, breach the blood-brain barrier — and points toward new ways of stopping them. 🦟🧠

#ResearchPowersProgress

stemcell.ucla.edu/news/headspa...

Mosquito-borne viruses can cause more than fevers and joint pain. In severe cases, they invade the brain, leading to seizures, encephalitis, lasting memory loss and sometimes death. But thanks to a ne...

UCLA researchers find how epilepsy genes disrupt different brain regions using stem cell models

Reposted by UCLA Broad Stem Cell Research Center

Emily R. Trunnell, Ph.D. @ertrunnell.bsky.social · 19d

Researchers at @uclastemcell.bsky.social & @dgsomucla.bsky.social created the first human hippocampal #assembloid model, which can be used to study epilepsy as well as neurodevelopmental, neurodegenerative, and other brain disorders.

stemcell.ucla.edu/news/ucla-re...

#devbio #neuroskyence 🧪

For families of children with severe epilepsy, controlling seizures is often just the beginning of their challenges. Even in cases where powerful medications can reduce seizures, many children continu...

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UCLA Broad Stem Cell Research Center @uclastemcell.bsky.social · 20d

A UCLA research team led by Dr. Donald Kohn is developing a one-time stem cell gene therapy treatment for deadly blood disorder alpha thalassemia major that’s potentially curative.

#ResearchPowersProgress: newsroom.ucla.edu/releases/ste...

UCLA scientists reprogram stem cells to create renewable cancer-fighting T cells

Reposted by UCLA Broad Stem Cell Research Center

California Institute for Regenerative Medicine (CIRM) @cirmnews.bsky.social · 28d

CIRM-funded @uclastemcell.bsky.social researchers reprogrammed blood #StemCells to produce #cancer-targeting T cells—offering a renewable path for immunotherapy. Early results are promising for treatment-resistant tumors.

#BlueskyBiotech

In a first-of-its-kind clinical trial, UCLA scientists have shown it’s possible to reprogram a patient’s blood-forming stem cells to generate a continuous supply of functional T cells, the immune syst...

ScaleReady Awards G-Rex® Grants to Support Cell and Gene Therapy Manufacturing in California

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UCLA Broad Stem Cell Research Center @uclastemcell.bsky.social · 26d

Congratulations to Dr. Dawn Ward of the UCLA Human Gene and Cell Therapy Facility for receiving a G-Rex Grant that will support production of a novel iNKT cell therapy developed by Dr. Lili Yang! 🦠🧪🧫

🔗 bit.ly/46bUIso

#ResearchPowersProgress

/PRNewswire/ -- ScaleReady, in collaboration with Wilson Wolf Manufacturing, Bio-Techne Corporation (NASDAQ: TECH) and CellReady, today announced that eight...

UCLA Broad Stem Cell Research Center @uclastemcell.bsky.social · Sep 8

Live recordings show neural activity in hippocampal assembloids derived from patient stem cells. In the healthy control (left), neurons fire independently. In the assembloid with the SCN8A gene variant (right), neurons fire together in sudden flashes — an abnormal pattern associated with seizures.

UCLA Broad Stem Cell Research Center @uclastemcell.bsky.social · Sep 8

Using #stemcell models, @ucla.edu scientists find how epilepsy genes disrupt different brain regions. The study establishes the first hippocampal assembloid model, creating a new platform for studying epilepsy, autism and Alzheimer’s disease.

#ResearchPowersProgress 🔗 bit.ly/3JTyjbR

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UCLA Broad Stem Cell Research Center @uclastemcell.bsky.social · Sep 5

These findings suggest that both blood stem cells and their environments should be considered to develop more effective interventions that improve overall blood production as we age, helping people live healthier for longer.

#Aging #AgingResearch #StemCellResearch #RegenerativeMedicine

UCLA Broad Stem Cell Research Center @uclastemcell.bsky.social · Sep 5

First, inflammatory responses within blood stem cells themselves reduce their ability to produce blood cells of all kinds. Second, inflammatory signaling in the surrounding milieu — the cells that support blood stem cells — directly impacts the types of blood cells produced.

UCLA scientists use mini organ models to uncover secrets of deadly hantaviruses and point to new treatments

UCLA Broad Stem Cell Research Center @uclastemcell.bsky.social · Sep 5

New in @cp-cellreports.bsky.social ➡️ bit.ly/4mVlAUO

Aging is associated with chronic inflammation and altered blood cell production, reducing immunity and increasing blood cancer risk. Dr. Jennifer Chia and team find that chronic inflammation plays two distinct roles in blood system aging.

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Reposted by UCLA Broad Stem Cell Research Center

cniostopcancer.bsky.social @cniostopcancer.bsky.social · Sep 4

👥#CFM_MolCellAging: In the second session, we'll hear talks on cancer and aging from:

Thomas_Rando @uclastemcell.bsky.social
@efeyanlab.bsky.social at #CNIOStopCancer
@EileenWhitePhD @rutgerscancer.bsky.social

Register at: bit.ly/4kOyYch

🤝With support of @caixaresearch.bsky.social

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UCLA Broad Stem Cell Research Center @uclastemcell.bsky.social · Aug 27

Researchers at UCLA built mini models of human lungs, hearts and brains to study hantaviruses and identify potential therapies. With no current treatments, these deadly rodent-borne viruses pose a serious threat to public health. #ResearchPowersProgress

stemcell.ucla.edu/news/ucla-sc...

UCLA researchers have created miniature stem cell-based organoid models of human lungs, hearts and brains to study how hantaviruses — rare but often deadly viruses spread by rodents — infect the body....

UCLA scientists map primate ovarian reserve development, offering key insights into women’s health

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UCLA Broad Stem Cell Research Center @uclastemcell.bsky.social · Aug 26

UCLA scientists have developed the first comprehensive road map showing how the ovarian reserve forms in primates. The findings could lead to better treatments for #infertility and hormonal disorders like #PCOS. #ResearchPowersProgress
stemcell.ucla.edu/news/ucla-sc...

UCLA scientists have developed the first comprehensive road map showing how the ovarian reserve forms in primates, providing crucial insights into women’s health that could revolutionize treatments fo...

Rejuvenating our bodies through regenerative medicine

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UCLA Broad Stem Cell Research Center @uclastemcell.bsky.social · Aug 22

UCLA neuroscience Ph.D. candidate Elle Rathbun studies potential treatments that could help repair the brain after stroke. Grant suspensions have halted this life-saving research. #ResearchPowersProgress

🔗 ucla.in/4oIH9t3
➡️ Help protect UCLA's future: www.ucla.edu/research

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UCLA Broad Stem Cell Research Center @uclastemcell.bsky.social · Aug 14

To fight aging, injury and disease, UCLA researchers are imagining ways to restore function at the deepest cellular level. Learn how #RegenerativeMedicine is offering hope to expand the body's ability to heal:

#ResearchPowersProgress

stemcell.ucla.edu/news/rejuven...

In ancient Greek mythology, the Titan Prometheus stole fire from Zeus and gifted it to humankind. Zeus took his vengeance by chaining Prometheus to a mountain and torturing him. Every day, an eagle wo...

Scientists create organoids with specialized blood vessels

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UCLA Broad Stem Cell Research Center @uclastemcell.bsky.social · Aug 13

UCLA scientists have developed a new type of immunotherapy that's more effective at fighting ovarian cancer than conventional CAR-T cell therapy in preclinical studies. The team will now seek FDA approval to open a clinical trial.

newsroom.ucla.edu/stories/immu...

#ResearchPowersProgress

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UCLA Broad Stem Cell Research Center @uclastemcell.bsky.social · Aug 6

With support from the NIH, UCLA researcher Dr. @mingxiagu.bsky.social & her team have created the first mini-lungs with specialized blood vessels — offering insights into how lungs develop and function, and unlocking new approaches to tackling pulmonary vascular disease. www.nih.gov/news-events/...

Scientists made mini-lungs and intestines, called organoids, that generate their own specialized blood vessels.

www.nih.gov

UCLA scientists reprogram stem cells to create renewable cancer-fighting T cells

UCLA Broad Stem Cell Research Center @uclastemcell.bsky.social · Jul 31

In a first-of-its-kind clinical trial, UCLA scientists have shown it’s possible to reprogram a patient’s own stem cells to create a continuous supply of functional T cells, the immune system’s most powerful cancer-killing agents. bit.ly/4fhvMnv

#CancerResearch #StemCellResearch

In a first-of-its-kind clinical trial, UCLA scientists have shown it’s possible to reprogram a patient’s blood-forming stem cells to generate a continuous supply of functional T cells, the immune syst...

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UCLA Broad Stem Cell Research Center @uclastemcell.bsky.social · Jul 28

Meet Dr. D'Juan Farmer, a UCLA scientist who studies the cellular and molecular mechanisms that regulate the development of the skull and face. He shares the impact he hopes to make for patients with congenital anomalies and his affinity for fantasy novels. ➡️ bit.ly/4l4GpLN

#StemCellResearch