UC Santa Cruz Genomics Institute
@ucscgenomics.bsky.social
1.4K followers 130 following 110 posts
Focusing the power of genomics to create a healthier world. Leader in pangenomics, conservation genomics, cancer genomics, pathogen genomics, and nanopore sequencing. Home of the UCSC Genome Browser, @ucscxena, UShER, Dockstore, and other high-power tools.
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ucscgenomics.bsky.social
A court ruling in favor of @ucsantacruz.bsky.social Genomics Institute associate Ed Geen's startup Astrea Forensics paves the way for whole-genome sequencing, a cutting-edge technique used on degraded DNA in fossilized remains, to be admitted as evidence in trials 🦴🔍 www.nature.com/articles/d41...
A man in a lab coat and glasses examines a snip of hair in a plastic bag.
Reposted by UC Santa Cruz Genomics Institute
genomebrowser.bsky.social
We are pleased to announce the release of the Developmental Disorders Genotype-to-Phenotype (DDG2P) track for hg19 and hg38. The DDG2P track displays genes associated with severe developmental disorders.

Learn more at:
genome.ucsc.edu/gold...
ucscgenomics.bsky.social
Breakthrough disease treatments are being developed, but they need #NIH funding! @khmiga.bsky.social and Krizia Chambers joined #RallyForMedicalResearch on Capitol Hill to tell lawmakers how important federal funding is to their research.

🧪🔬 Message your lawmakers: news.ucsc.edu/2025/09/advo...
Karen Miga and Krizia Chambers standing on the steps of Capitol Hill Krizia Chambers, Karen Miga, and two other women sit at a coffee table. Krizia is speaking to Representative Jimmy Panetta, who is standing listening to her with his hands clasped in front of him.
ucscgenomics.bsky.social
Scientists at @ucsc have built an automated platform to grow and monitor brain organoids (brain tissue in a dish) 24/7 🧠🤖. It captures neural activity missed by manual methods—boosting reproducibility & paving the way for breakthroughs in brain research.
www.sciencedirect.com/science/arti...
A decorative illustration of a petri dish underneath what looks like a high-powered microscope. It is attached via a tube to another dish.
ucscgenomics.bsky.social
📢 Announcing the AnVIL Data Explorer!
This tool makes it easier to access and reuse high-value datasets, including those that focus on specific diseases like Alzheimer’s, cancer, and rare genetic disorders. Over 280 datasets are already available, with more to come.
news.ucsc.edu/2025/08/new-...
AnVIL Data Explorer logo
ucscgenomics.bsky.social
🧑🧬🐒 Are humans and chimps *really* 99% similar? New telomere-to-telomere (T2T) genomes and other sequencing advancements are helping scientists reveal more differences, primarily in the "non-coding" regions of DNA that turn genes on and off.

www.livescience.com/archaeology/...
Do humans and chimps really share nearly 99% of their DNA?
The frequently cited 99% similarity between human and chimp DNA overlooks key differences in the genomes.
www.livescience.com
ucscgenomics.bsky.social
🌎 The Earth BioGenome Project is proposing to sequence 150,000 species over 4 years--which means releasing 3,000 new genomes a month ‼️

We're proud to be participating in this effort to create a rich resource to inform conservation, ensure food security, and even advance medicine.
ebpgenome.bsky.social
🚀🧬🔥 Hot off the press — 2025!
Don’t miss this must-read publication: bit.ly/4mJwFb7

This groundbreaking paper sets the stage for Earth BioGenome Project Phase II — where EBP is gearing up to scale genome sequencing 10× faster than ever before! 🌍✨
Reposted by UC Santa Cruz Genomics Institute
aidemm.bsky.social
Congratulations to lab member Maria! Maria joined us this summer as an NHGRI GREAT scholar @ucscgenomics.bsky.social Within 8 weeks she learned new wet lab techniques, bioinformatics, and carried out independent research. Proud to share that she received an award for outstanding research poster.
Woman standing in front of a poster at a conference Woman smiling holding a certificate
Reposted by UC Santa Cruz Genomics Institute
genomebrowser.bsky.social
We are excited to announce the release of the MaveDB Experiment Heatmaps and Alignment track for hg38. Each heatmap shows the results of many small substitutions that were tested within a gene to examine their functional consequences.

Learn more at:
http://bit.ly/4lCIlLq
ucscgenomics.bsky.social
It's exciting to see the continuing legacy of T2T sequencing methods being discussed on @scifri.bsky.social ! 🧬
Complete genomes are helping us understand more and more about genetic function and diversity in areas of our DNA that were unreadable just a few years ago.
Reposted by UC Santa Cruz Genomics Institute
genomebrowser.bsky.social
We’re excited to announce support for bedMethyl and bigMethyl, new track formats for visualizing base-resolution DNA methylation from bisulfite sequencing or similar methods at single-base resolution across the genome in the UCSC Genome Browser. More info: genome.ucsc.edu/gold...
ucscgenomics.bsky.social
The @nativebio.bsky.social is working to create the D4I Tribal Data Repository to uphold Indigenous data sovereignty 🧬🤝

In this video, a few of our collaborators on this project explain what it means to protect tribal data, and why it matters: www.youtube.com/watch?v=twp6...
D4I Tribal Data Repository - Protecting Tribal Data & Why It Matters
YouTube video by D4I TDR
www.youtube.com
ucscgenomics.bsky.social
Can a father’s stress influence the health of his future children?

Science says yes. Affiliate @upasnasharma.bsky.social studies this effect in mice, and she has received a new McKnight Foundation award to uncover the molecular signals in sperm that are behind it: news.ucsc.edu/2025/07/upas...
A scared-looking rat with a hunched back stands in a corner looking wearily in the direction of the viewer.
ucscgenomics.bsky.social
🦭🧬 After nearly going extinct, northern elephant seals bounced back, but lost almost all genetic variation.

Now, thanks to a new tool out of @ucsantacruz.bsky.social, we can trace family lines for species with low genetic diversity and improve conservation strategies.

📄: doi.org/10.1111/acv....
Two male elephant seals face each other in a display of dominance, with chests puffed and their large noses in the air. Female seals and their pups lie around the bull on the left.
ucscgenomics.bsky.social
Over 1,100 members of the National Academies of the Sciences, representing both political parties, have signed a letter urging Congress to reject the FY26 science budget cuts that threaten U.S. leadership in science, health, and national security. #StandUpForScience www.youtube.com/watch?v=Vkv0...
Letter from NAS Members to the Honorable Senators and Representatives of the United States
YouTube video by Biochemistry Channel
www.youtube.com
ucscgenomics.bsky.social
🧪🧬🖥️ We have a new variation graphs (vg) update: github.com/vgteam/vg/re...

Changes include:
🤝Improved compatibility with other GFA graph files and transcript annotation files
🪲Various bug fixes, especially for mis-named or broken command-line options
vg graphs logo
ucscgenomics.bsky.social
📣 JOB ALERT: We are looking for a Senior Software Engineer to join our pathogen genomics team! Be a part of creating and maintaining tools that public health officials are using to track the spread of dangerous pathogens 🦠

Apply here:
careerspub.universityofcalifornia.edu/psc/ucsc/EMP...
An error has occurred.
careerspub.universityofcalifornia.edu
ucscgenomics.bsky.social
Our work on the AnVIL Explorer is facilitating better data sharing ☁️ This database of roughly 12.9K biosamples allows users to explore public and controlled-access data to find datasets that are relevant to their work.
geneticssociety.bsky.social
Data sharing is crucial to advancing health research. @ajhgnews.bsky.social's latest article provides policy recommendations to facilitate future use & sharing of heterogeneous data sources w/ a goal of improving polygenic risk prediction: www.cell.com/ajhg/abstrac... @prsdiversity.bsky.social