Uddalok Jana
@uddalok.bsky.social
PhD student @ University of Louisville
Reposted by Uddalok Jana
New BCR reconstruction tool for scRNA-seq: assembles full heavy & light chains and annotates constant regions. Check it out:
www.biorxiv.org/content/10.1...
#scRNAseq #immunology
www.biorxiv.org/content/10.1...
#scRNAseq #immunology
GATHeR: Graph-based Accurate Tool for Immunoglobulin HEavy- and Light-chain Reconstruction
Recovering full-length, paired B-cell receptor (BCR) sequences from scRNA-seq reads remains difficult, especially in naive and memory B cells where immunoglobulin transcripts are sparse. Current metho...
www.biorxiv.org
September 22, 2025 at 4:50 AM
New BCR reconstruction tool for scRNA-seq: assembles full heavy & light chains and annotates constant regions. Check it out:
www.biorxiv.org/content/10.1...
#scRNAseq #immunology
www.biorxiv.org/content/10.1...
#scRNAseq #immunology
Reposted by Uddalok Jana
Turns out...just like in the antibody heavy chain repertoire, germline variants in the immunoglobulin lambda and kappa loci influence the composition of light chain B cell receptors!
Way to go Eric @e-engelbrecht1.bsky.social !!!!
www.biorxiv.org/content/10.1...
Way to go Eric @e-engelbrecht1.bsky.social !!!!
www.biorxiv.org/content/10.1...
Germline polymorphism in the immunoglobulin kappa and lambda loci explain variation in the expressed light chain antibody repertoire
Variation in antibody (Ab) responses contributes to disease outcomes and therapeutic responsiveness, the determinants of which remain incompletely understood. This study demonstrates that polymorphism...
www.biorxiv.org
June 2, 2025 at 1:13 AM
Turns out...just like in the antibody heavy chain repertoire, germline variants in the immunoglobulin lambda and kappa loci influence the composition of light chain B cell receptors!
Way to go Eric @e-engelbrecht1.bsky.social !!!!
www.biorxiv.org/content/10.1...
Way to go Eric @e-engelbrecht1.bsky.social !!!!
www.biorxiv.org/content/10.1...
Reposted by Uddalok Jana
Very proud of this collective effort to enhance understanding of immunoglobulin diversity in rhesus macaque @guryaari.bsky.social @williamlees.bsky.social
www.biorxiv.org/content/10.1...
--> NEW and IMPROVED germline sets for this important animal model...explore here: vdjbase.org/reference_bo...
www.biorxiv.org/content/10.1...
--> NEW and IMPROVED germline sets for this important animal model...explore here: vdjbase.org/reference_bo...
A Broad Survey and Functional Analysis of Immunoglobulin Loci Variation in Rhesus Macaques
Rhesus macaques (RMs) are a vital model for studying human disease and invaluable to pre-clinical vaccine research, particularly for the study of broadly neutralizing antibody responses. Such studies ...
www.biorxiv.org
March 6, 2025 at 7:43 PM
Very proud of this collective effort to enhance understanding of immunoglobulin diversity in rhesus macaque @guryaari.bsky.social @williamlees.bsky.social
www.biorxiv.org/content/10.1...
--> NEW and IMPROVED germline sets for this important animal model...explore here: vdjbase.org/reference_bo...
www.biorxiv.org/content/10.1...
--> NEW and IMPROVED germline sets for this important animal model...explore here: vdjbase.org/reference_bo...