Nature Communications - MUTYH removes A mis-incorporated opposite oxidized guanine to thwart mutations. Here, the authors present crystal structures and assess functional impacts and molecular...

Reactive oxygen species induce mutagenic DNA lesions, such as 8-oxo-2′-deoxyguanosine (8-oxodG), which acts as a template for dCMP and dAMP incorporation through its anti and syn conformations. Speci....