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Golnaz Vahedi @vahedilab.bsky.social · 1d

In this article, I share my perspective on leveraging AI and single-cell profiling to predict type 1 diabetes. It’s great to see the diverse insights contributed by other experts in the field: www.nature.com/articles/s42...

Artificial intelligence in metabolic research - Nature Metabolism

The recent developments in artificial intelligence (AI) have created both intrigue and apprehension in the world of research. In this Viewpoint, we asked 12 experts in the field of metabolism to share their — differing — opinions on the use of AI in pre-clinical and clinical metabolic research.

www.nature.com

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Golnaz Vahedi @vahedilab.bsky.social · 2d

Congrats!

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Reposted by Golnaz Vahedi

Dr. Amanda Poholek @poholeklab.bsky.social · 2d

Thrilled to share my promotion to Associate Professor with tenure at @pitt-immunology.bsky.social! Huge thanks to my incredible lab, collaborators, department, colleagues, family & friends. Science is a team effort, and I'm so proud of our work & excited for what's next! Stay tuned!

Pitt Department of Immunology @pitt-immunology.bsky.social · 2d

Congratulations to Dr. Amanda Poholek @poholeklab.bsky.social for her promotion to Associate Professor with tenure! Learn more about Dr. Poholek and her research: buff.ly/q14wey8

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Golnaz Vahedi @vahedilab.bsky.social · 5d

Congrats!

Golnaz Vahedi @vahedilab.bsky.social · 15d

The Vahedi Lab is seeking a highly motivated Research Specialist A/B to join our dynamic research group studying the mechanisms of immune regulation. Apply here: wd1.myworkdaysite.com/recruiting/u...

Research Specialist A/B

University Overview The University of Pennsylvania, the largest private employer in Philadelphia, is a world-renowned leader in education, research, and innovation. This historic, Ivy League school co...

wd1.myworkdaysite.com

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Reposted by Golnaz Vahedi

John Ray @jraylab.bsky.social · 20d

Excited to finally present the lab's latest work in defining candidate causal genetic variants that drive autoimmune diseases and their effects on primary human T cell expression and function! www.nature.com/articles/s41...

Genetic and epigenetic screens in primary human T cells link candidate causal autoimmune variants to T cell networks - Nature Genetics

Massively parallel reporter assay in primary human CD4+ T cells and bulk and single-cell CRISPR-interference screens identify candidate causal variants linked to autoimmune disease risk that modulate ...

www.nature.com

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Golnaz Vahedi @vahedilab.bsky.social · Aug 19

Excellent news!

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Golnaz Vahedi @vahedilab.bsky.social · Jul 13

New preprint in collaboration with the Faryabi lab: Optical Looping Interactive Viewing Engine (OLIVE), a web-based tool designed for high-throughput chromatin tracing data that functions similarly to genome browsers. If you work with these data, give a try: www.biorxiv.org/content/10.1...

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Golnaz Vahedi @vahedilab.bsky.social · Jun 26

If you are interested in T and B cells, you can look your favorite gene and its connectivity here: sorayoon.shinyapps.io/HiCociety/

Hi-Cociety Web DatabaseInference of multi-enhancer interactions from T lymphocytes using Hi-CocietyDescription of table columns

sorayoon.shinyapps.io

Golnaz Vahedi @vahedilab.bsky.social · Jun 26

Hi-Cociety does magic: it takes Hi-C data and determines cell-type specific highly connected regions without taking any additional input.

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Golnaz Vahedi @vahedilab.bsky.social · Jun 26

🚨 New #preprint alert!
We're excited to share the latest work from the brilliant Sora Yoon: "Inference of multi-enhancer interactions in T lymphocytes using Hi-Cociety"🔗 www.biorxiv.org/content/10.1...

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Reposted by Golnaz Vahedi

Golnaz Vahedi @vahedilab.bsky.social · Jun 2

🚨 New #preprint alert!
We're excited to share our latest work:
"Single-Allele Chromatin Tracing Reveals Genomic Clustering of Paralogous Transcription Factors as a Mechanism for Developmental Robustness in T Cells"🔗 tinyurl.com/4ve26tbd

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Golnaz Vahedi @vahedilab.bsky.social · Jun 2

Deep gratitude to the Vahedi and Faryabi Labs and all our supporters and funders who made this possible! #Tcells #chromatin #generegulation #microscopy #epigenetics #immunology #developmentalbiology #ORCA #teamwork

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Golnaz Vahedi @vahedilab.bsky.social · Jun 2

✨ This is the first chromatin tracing study in immune cells, and we're incredibly proud of the team for reaching this milestone.

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Golnaz Vahedi @vahedilab.bsky.social · Jun 2

🧬 Key findings:
The dominant chromatin conformation pulls Ets1 close to its super-enhancer, spatially separating it from Fli1.
Deleting the super-enhancer rewires the locus, increasing Ets1–Fli1 promoter-promoter interactions.
This suggests that enhancer "pulling" override domain boundaries.

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Golnaz Vahedi @vahedilab.bsky.social · Jun 2

💡 Huge thanks to Alistair Boettiger, Guy Nir, Ting Wu, and their lab members for their generous help in troubleshooting the approach.

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Golnaz Vahedi @vahedilab.bsky.social · Jun 2

To investigate, we needed to resolve chromatin architecture at single-allele resolution in individual cells. Atishay and Yeqiao implemented ORCA (Optical Reconstruction of Chromatin Architecture)—a sub-diffraction microscopy method—that lets us walk along the chromosome.

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Golnaz Vahedi @vahedilab.bsky.social · Jun 2

🔍 Our question: Why are certain paralogous transcription factors—like Ets1 and Fli1—maintained in close genomic proximity across hundreds of millions of years?

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Golnaz Vahedi @vahedilab.bsky.social · Jun 2

This study was a huge team effort, led by the brilliant @atishayjay.bsky.social in close collaboration with Yeqiao Zhao in the @faryabi.bsky.social Lab, with key contributions from @arjunraj.bsky.social, whose Nimbus image analysis tool was essential.

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Golnaz Vahedi @vahedilab.bsky.social · Jun 2

🚨 New #preprint alert!
We're excited to share our latest work:
"Single-Allele Chromatin Tracing Reveals Genomic Clustering of Paralogous Transcription Factors as a Mechanism for Developmental Robustness in T Cells"🔗 tinyurl.com/4ve26tbd

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Golnaz Vahedi @vahedilab.bsky.social · May 24

Wonderful news. Very well deserved

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Golnaz Vahedi @vahedilab.bsky.social · May 24

Wonderful news. Congrats!

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Golnaz Vahedi @vahedilab.bsky.social · May 16

Sometimes you only need to focus on good news: www.nytimes.com/2025/05/15/h...

Baby Is Healed With World’s First Personalized Gene-Editing Treatment

www.nytimes.com

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Golnaz Vahedi @vahedilab.bsky.social · May 8

Thanks for the opportunity!

Reposted by Golnaz Vahedi

Global Immunotalks @globalimmuno.bsky.social · May 7

The recorded video of Dr. Golnaz Vahedi seminar entitled Chromatin topology at paralogous transcription factors is now available at “Global Immunotalks” YouTube Channel youtube.com/live/7aw_Qx5...
Please ask questions in the Youtube comment section for Golnaz.
Hope you enjoy it!

GLOBAL IMMUNOTALKS: Virtual immunology seminar series

YouTube video by GLOBAL IMMUNOTALKS

youtube.com

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