Hanna Allerkamp
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vethannaphd.bsky.social
Hanna Allerkamp
@vethannaphd.bsky.social
Postdoc @MedUniGraz | PlacentaLab @WadsackLab | Vet

#TeamPlacenta #Cuterus
via Pregnancy Modelling Group @ University of Auckland
placentalab.science
Thank you so much for highlighting our work! 🫶
February 22, 2025 at 12:07 PM
3/ Why care? Early-onset preeclampsia affects 2–10% of pregnancies and has long-term consequences for both mom & baby. Targeting Piezo1 & TRPV4 might hold therapeutic potential in the future.
Huge thanks to all collaborators @MedUniGraz! Read @AJPCellPhys journals.physiology.org/doi/full/10....
In vitro examination of Piezo1-TRPV4 dynamics: implications for placental endothelial function in normal and preeclamptic pregnancies | American Journal of Physiology-Cell Physiology
Mechanosensation is essential for endothelial cell (EC) function, which is compromised in early-onset preeclampsia (EPE), impacting offspring health. The ion channels Piezo-type mechanosensitive ion c...
journals.physiology.org
February 1, 2025 at 10:32 AM
2/ Our findings? In EPE, these channels aren't playing nice. Calcium signaling? Reduced. Nitric oxide production? Complicated. And the endothelial barrier? We’re seeing serious cracks. Turns out, teamwork makes the placenta work—when it's healthy.
#TeamPlacenta #preeclampsia
February 1, 2025 at 10:32 AM