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Vaccine & Gene Therapy Institute

@vgti.bsky.social

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VGTI provides lifesaving solutions through transformative biomedical discovery and research, enabling the prevention and cure of global infectious diseases. www.ohsu.edu/vaccine-gene-therapy-institute

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Vaccine & Gene Therapy Institute @vgti.bsky.social · Dec 17

Located on the OHSU West campus, the VGTI is a free-standing facility that includes access to biosafety level 3 laboratories, and state-of-the-art core technologies such as spatial profiling and transcriptomics, single cell transcriptomics, and flow cytometry. Current faculty engage in

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Vaccine & Gene Therapy Institute @vgti.bsky.social · 5d

Read the full article here:
pubmed.ncbi.nlm.nih.gov/41004538/

Liver biopsies obtained throughout SIV infection reveal evolving interferon stimulated protein expression within distinct monocyte/macrophage subsets - PubMed

Liver dysfunction is more common and more severe among people with HIV than in the general population. Our previous transcriptomic analysis identified an increased hepatic type-1 interferon (IFN-1) re...

pubmed.ncbi.nlm.nih.gov

Vaccine & Gene Therapy Institute @vgti.bsky.social · 5d

Liver dysfunction is more common and severe among people with HIV than in the general population. In this recent publication, our Burwitz affiliate lab explores the correlation between different cell types in the IFN-1 response, focusing on macrophage subsets during the acute phase of SIV infection.

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Vaccine & Gene Therapy Institute @vgti.bsky.social · 8d

...of the enzymes involved in their biosynthesis.

Read the full article here: pubmed.ncbi.nlm.nih.gov/40659247/

Integrated lipidomic and proteomic profiling reveals metabolic network disruption by SARS-CoV-2 variants - PubMed

The rapid evolution of SARS-CoV-2 has produced myriad viral strains with increasing transmissibility and capacity for immune evasion. While effective vaccination campaigns have reduced the fatalities ...

pubmed.ncbi.nlm.nih.gov

Vaccine & Gene Therapy Institute @vgti.bsky.social · 8d

In their recent publication, our Tafesse affiliate lab with their contributors, explore SARS-CoV-2 and whether the patterns of host lipid rewiring remained consistent across variants and whether the changes in the abundance of lipid classes are related to changes in the expression...

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Vaccine & Gene Therapy Institute @vgti.bsky.social · 21d

...their potential antiviral activity, as typically prodrugs increase solubility and delivery. Additional studies are underway to elucidate the mechanism of action of these analogues.

Read the full article here: pubmed.ncbi.nlm.nih.gov/40939252/

Novel tricycle expanded purine nucleosides with pan-viral activity - PubMed

A series of thiophene-expanded tricyclic nucleosides featuring modifications not previously investigated, including sugar and nucleobase modifications, were synthesized as potential antiviral therapeu...

pubmed.ncbi.nlm.nih.gov

Vaccine & Gene Therapy Institute @vgti.bsky.social · 21d

In collaboration with Dr. Seley-Radtke’s group at the University of Maryland, our Hirsch lab has contributed to a study identifying a new series of thiophene-expanded tricyclic nucleosides as potential antiviral therapeutics. In addition, their corresponding prodrugs were also pursued to probe...

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Vaccine & Gene Therapy Institute @vgti.bsky.social · Sep 4

In addition, MHC-E has a number of fascinating functions in regulating immunity that have many possible applications for the development of vaccines and immunotherapies against infectious diseases and cancer." -Klaus Früh, Ph.D.

Here is a link to the full text:
www.nature.com/articles/s41...

Targeting MHC-E as a new strategy for vaccines and immunotherapeutics - Nature Reviews Immunology

The dual nature of non-polymorphic MHC-E as a ligand for innate receptors and as an antigen-presenting protein raises the possibility of new, universally effective vaccines and immunotherapies for inf...

www.nature.com

Vaccine & Gene Therapy Institute @vgti.bsky.social · Sep 4

MHC-E is a non-classical MHC class I protein that has been studied for many years by the Oxford group and that we stumbled upon in our research on using cytomegalovirus as a novel vaccine vector. We found that T cells targeting MHC-E might be the key to the development of an AIDS vaccine
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Vaccine & Gene Therapy Institute @vgti.bsky.social · Sep 4

"Everything you always wanted to know about MHC-E, but were afraid to ask.... is covered in this Nature Review, the result of a team effort together with Louis Picker here at OHSU and Andrew McMichael, Geraldine Gillespie and Persephone Borrow from University of Oxford.
(continued)

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Vaccine & Gene Therapy Institute @vgti.bsky.social · Sep 2

Read the full article here:
pubmed.ncbi.nlm.nih.gov/40862619/

Impact of obesity on the gut microbiome and inflammatory markers during SIV infection and antiretroviral therapy - PubMed

Dysbiosis and impaired gut barrier integrity contribute to chronic immune activation associated with both obesity and HIV infection. Given the increased incidence of obesity in people living with HIV,...

pubmed.ncbi.nlm.nih.gov

Vaccine & Gene Therapy Institute @vgti.bsky.social · Sep 2

Our Sacha Affiliate Lab, with their contributors, have recently published a new study where they explored the impact of obesity on the gut microbiome and microbial translocation (MT) biomarkers during HIV infection and antiretroviral therapy (ART). Amazing work done by all!

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Vaccine & Gene Therapy Institute @vgti.bsky.social · Aug 29

... facilitates the development of safe and efficacious vaccines in humans.

Read the full article here:
academic.oup.com/jimmunol/art...

Glycoprotein L–deleted single-cycle rhesus cytomegalovirus vectors elicit MHC-E–restricted CD8+ T cells that protect against SIV

Abstract. Strain 68-1 rhesus CMV (RhCMV) vectors induce immune responses that mediate early, complete replication arrest of SIV infection in ∼60% of vaccin

academic.oup.com

Vaccine & Gene Therapy Institute @vgti.bsky.social · Aug 29

This study by Dr Hansen et al. demonstrates that CMV-based vaccines protect against SIV even when highly attenuated by deleting a glycoprotein essential for CMV entry. The remarkable ability to uncouple viral spreading from its immunogenicity is a unique feature of CMV based vectors and...

Vaccine & Gene Therapy Institute @vgti.bsky.social · Aug 22

Incredible work by the Bimber, Okoye, Sacha, Estes, Axthelm, Streblow, Hansen, Picker lab teams with their contributors.

Read the full article here:

www.researchgate.net/publication/...

(PDF) An immune-focused supplemental alignment pipeline captures information missed from dominant single-cell RNA-seq analyses, including allele-specific MHC-I regulation

PDF | Introduction RNA sequencing (RNA-seq) can measure whole transcriptome gene expression from tissues or even individual cells, providing a powerful... | Find, read and cite all the research you ne...

www.researchgate.net

Vaccine & Gene Therapy Institute @vgti.bsky.social · Aug 22

This recently published paper titled, "An immune-focused supplemental alignment pipeline captures information missed from dominant single-cell RNA-seq analyses, including allele-specific MHC-I regulation" showcases an incredible collaboration between between the VGTI Labs and Affiliate Labs.

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Vaccine & Gene Therapy Institute @vgti.bsky.social · Aug 21

Read the full article here:
pubmed.ncbi.nlm.nih.gov/40670406/

The TLR7/8 agonist INI-4001 enhances the immunogenicity of a Powassan virus-like-particle vaccine - PubMed

Powassan virus (POWV) is a pathogenic tick-borne flavivirus that causes fatal neuroinvasive disease in humans. There are currently no approved therapies or vaccines for POWV infection. Here, we develo...

pubmed.ncbi.nlm.nih.gov

Vaccine & Gene Therapy Institute @vgti.bsky.social · Aug 21

There are currently no approved therapies or vaccines for Powassan virus infection. In this recent publication, our Hirsch lab and their contributors, developed a POW virus-like particle (POW-VLP) based vaccine adjuvanted with the novel synthetic Toll-like receptor 7/8 agonist INI-4001.

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Vaccine & Gene Therapy Institute @vgti.bsky.social · Aug 7

...corresponding orthologs to HCMV.

Read the full article here:
pubmed.ncbi.nlm.nih.gov/40736257/

Cytomegalovirus latency-the sum of subtleties - PubMed

Human cytomegalovirus (HCMV) is a betaherpesvirus, which, like all herpesviruses, establishes a life-long latent infection while retaining the ability to reactivate its replicative program. While HCMV...

pubmed.ncbi.nlm.nih.gov

Vaccine & Gene Therapy Institute @vgti.bsky.social · Aug 7

Our Hancock, Caposio, and Streblow Labs with their contributors, have recently published this review on the current understanding of HCMV latency. They focus on cross-cutting principles derived collectively from in vitro experimental culture models and in vivo animal models using the...

Reposted by Vaccine & Gene Therapy Institute

OHSU Brain Institute @ohsubrain.bsky.social · Aug 6

OHSU researchers have identified a gene that plays a crucial role in the brain's ability to form #myelin, potentially opening new doors to treatments for a rare childhood disorder and more common diseases such as #MultipleSclerosis. www.miragenews.com/gene-linked-...

Gene Linked to Widespread Disorders Identified

Discovery may open the way for new treatments for multiple sclerosis, leukodystrophies OHSU researchers discover a gene that helps cells

www.miragenews.com

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Vaccine & Gene Therapy Institute @vgti.bsky.social · Aug 5

...surface protein and marker genes as ground truth.

Read the full article here:
pubmed.ncbi.nlm.nih.gov/40233746/

Enhanced interpretation of immune cell phenotype and function through a rhesus macaque single-cell atlas - PubMed

Single-cell RNA sequencing (scRNA-seq) allows cell classification using genome-wide transcriptional state; however, high-dimensional transcriptomic profiles, and the unsupervised analyses employed to ...

pubmed.ncbi.nlm.nih.gov

Vaccine & Gene Therapy Institute @vgti.bsky.social · Aug 5

In this incredible collaboration our Estes, Okoye, Axthelm, Hansen, Picker, Bimber affiliate and lab teams— present the RIRA, the first immune-focused macaque single-cell multi-tissue atlas. They contrasted transcriptional profiles against immune lineages, using...

Vaccine & Gene Therapy Institute @vgti.bsky.social · Jul 31

Read the full article here:
pubmed.ncbi.nlm.nih.gov/40663406/

Prophylactic and therapeutic neutralizing monoclonal antibody treatment prevents lethal yellow fever infection - PubMed

Yellow Fever virus (YFV) infection is fatal in 5-10% of the 200,000 yearly cases. There is currently no available antiviral treatment. We showed previously that administration of 50 mg/kg of a YFV-spe...

pubmed.ncbi.nlm.nih.gov

Vaccine & Gene Therapy Institute @vgti.bsky.social · Jul 31

Recently publishing a paper on Yellow Fever our Burwitz, Axthelm, Estes, Bimber, and Sacha affiliate lab teams, further expand the potential clinical use of our YFV-specific nmAb. Which could be used during an outbreak for immediate prophylactic immunity or for patients with measurable serum viremia

Vaccine & Gene Therapy Institute @vgti.bsky.social · Jul 28

Read the full article here: pubmed.ncbi.nlm.nih.gov/40705709/

Effect of obesity on the acute response to SARS-CoV-2 infection and development of post-acute sequelae of COVID-19 (PASC) in nonhuman primates - PubMed

Long-term adverse consequences of SARS-CoV-2 infection, termed "long COVID" or post-acute sequelae of COVID (PASC), are a major component of overall COVID-19 disease burden. Prior obesity and metaboli...

pubmed.ncbi.nlm.nih.gov