Lightnews — Scholar-powered news

Vizgen @vizgen.bsky.social · 7d

MERFISH 2.0™ delivers a substantial increase in sensitivity, enabling detection of up to 10× more transcripts per field of view.

Discover how MERFISH 2.0 is transforming spatial biology for researchers like Dr. Bourdenx: hubs.ly/Q03LCNrY0 #SpatialBiology

Vizgen @vizgen.bsky.social · 12d

New data release highlights the power of MERSCOPE Ultra to capture high-resolution #spatialtranscriptomics across a 3.0 cm² imaging area:

• Mouse embryo tissue (E10, E12, and E14) on same slide
• Normal and Alzheimer’s human brain on same slide

hubs.ly/Q03KH7VN0

2

Vizgen @vizgen.bsky.social · 20d

Next-gen spatial transcriptomic tools are helping overcome the challenge of degraded & FFPE samples.

Vizgen co-founder Jiang He explains how these advances are opening new doors for research in oncology, neuroscience & beyond:
www.biocompare.com/Editorial-Ar...

1 1

Vizgen @vizgen.bsky.social · 22d

Just published in Nature: U Mass Chan Medical School, a Vizgen Certified Service Provider, mapped the brain’s molecular landscape across the human lifespan using MERSCOPE®, single-cell RNA-seq & genomic data.

Read: hubs.ly/Q03JsW0z0

#SpatialBiology #Neuroscience #AgingResearch

1

Vizgen @vizgen.bsky.social · 29d

From discovery to clinical research, #SpatialBiology is shaping precision medicine. With Vizgen, researchers now access:

➡️MERFISH 2.0™ spatial transcriptomics
➡️InSituPlex® multiplex protein analysis
➡️STARVUE™ AI image analysis

Explore our tech: hubs.ly/Q03GPSL70

1

Vizgen @vizgen.bsky.social · Sep 3

How do disseminated tumor cells reveal themselves in the bone marrow?

Using MERFISH 2.0™, Mark Watson, Ph.D.'s team can map 200K–500K cells from bone marrow aspirates and distinguish DTCs from other populations w/ a 140-gene panel.

Full webinar: hubs.ly/Q03GgGLm0

1

Vizgen @vizgen.bsky.social · Aug 26

New in @science.org: Researchers paired PEtracer with Vizgen’s MERSCOPE® to map how tumors evolve in vivo—showing how cell ancestry and local microenvironments shape growth and revealing new insights into tumor biology.

🔗 www.science.org/doi/10.1126/...

1

Vizgen @vizgen.bsky.social · Aug 25

MERFISH 2.0™ enables in situ spatial transcriptomic imaging in fixed frozen mouse bone marrow. ✨

At SR-TIGET, researchers quantified millions of transcripts— unlocking new insights into how cells interact in health and disease.

Explore MERFISH 2.0: vizgen.com/technology/#...

#SpatialBiology

2

Vizgen @vizgen.bsky.social · Aug 13

In @cp-cellreports.bsky.social: Researchers used MERSCOPE to help uncover how basophils activate fibroblasts to drive persistent skin inflammation, offering clues for potential new treatments for conditions like atopic dermatitis.

www.cell.com/cell-reports...

1

Vizgen @vizgen.bsky.social · Aug 6

Congrats to the winners of the 2025 Heidelberg MERFISH 2.0™ Grant Program! 🎉

In partnership with scOpenLab, we’re supporting cutting-edge spatial transcriptomics projects using MERFISH 2.0 and predesigned gene panels.

We can’t wait to see how these projects progress!

1

Vizgen @vizgen.bsky.social · Aug 1

Just launched: Vizgen’s Summer of Spatial Technology Evaluation Program!

Test industry-leading spatial transcriptomics & proteomics workflows on your own samples with expert support & exclusive pricing.

Limited to 10 projects—ends 9/22. Learn more: info.vizgen.com/form-summer-...

Vizgen @vizgen.bsky.social · Jul 28

In Nature: Engineered macrophages eliminated liver metastases in mice by restoring CD8⁺ T-cell activity and reprogramming the tumor microenvironment.

MERSCOPE® spatially mapped co-localized immune signals, revealing T-cell rejuvenation in the TME.

www.nature.com/articles/s41...

#Immunotherapy

Vizgen @vizgen.bsky.social · Jul 21

What makes spatial transcriptomics different?

• Single-cell resolution in spatial context
• Preserves tissue structure
• Reveals insights beyond traditional methods

Explore the basics: vizgen.com/what-is-spat...

1

Vizgen @vizgen.bsky.social · Jul 17

New in Cell: CXCL12 identified as a key genetic driver of coronary artery anatomy.

GWAS + spatial transcriptomics using MERSCOPE reveal how gene expression shapes heart development:
www.cell.com/cell/fulltex...

Vizgen @vizgen.bsky.social · Jul 15

Now in Singapore: MERSCOPE Ultra™!

We're thrilled to announce the first MERSCOPE Ultra install in Southeast Asia at LifeStrands Genomics, in partnership w/ Genomax Technologies.

Explore MERFISH 2.0 services now available to researchers across the region: spatial.lifestrandsgx.com/vizgen-mersc...

Vizgen @vizgen.bsky.social · Jul 7

Struggling with cell segmentation in complex tissues like multinucleated muscle or abnormally shaped cells? Enhance your cell segmentation with Vizgen's Cellpose2 Plugin!

Learn more about VPT and the plugin: vizgen.com/vpt/

#SpatialBiology

Vizgen @vizgen.bsky.social · Jul 1

More tissue. More speed. More power.

MERSCOPE Ultra™ brings 3X imaging area, 1.8X faster run time, and MERFISH 2.0 chemistry, all with sub-cellular resolution and FFPE compatibility.

See how spatial genomics scales: vizgen.com/merscope-ult...

#SpatialGenomics

Vizgen @vizgen.bsky.social · Jun 23

Uncovering how cells organize into functional niches is a major challenge in spatial biology.

A new study in Nature Genetics combines deep learning w/spatial transcriptomics from MERSCOPE® to map tissue architecture and cell communication across millions of cells.
www.nature.com/articles/s41...

2

Vizgen @vizgen.bsky.social · Jun 17

New study featured on the June cover of Nature Neuroscience used Vizgen’s MERSCOPE® to uncover how microglia and CD8⁺ T cells drive white matter degeneration in aging brains.

Learn more: vizgen.com/study-publis...

#SpatialBiology

2 2

Vizgen @vizgen.bsky.social · Jun 16

Ultivue by Vizgen’s new ADC OmniVUE™ Panels integrate advanced InSituPlex® assays with the STARVUE™ image data science pipeline, bringing speed, scale, and pathology-grade precision to clinical and translational research.

Learn more: ultivue.com/products/omn...

1

Vizgen @vizgen.bsky.social · Jun 10

🐟 MERFY Duo has landed in Singapore!

Take part in Vizgen’s #Cellfie promotion at #HCA2025 for a chance to win a MERSCOPE Ultra slide run using MERFISH 2.0 at Vizgen Lab Services.

Stop by booth #2 to learn more and explore the future of spatial biology with us.

Vizgen @vizgen.bsky.social · Jun 6

🐟Meet the Vizgen mascots! From Merfy to Ollie and now Merfy Duo (hatched this spring with MERFISH 2.0), each marks a milestone in spatial transcriptomics.

Heading to #HCA2025 in Singapore? Swim by our booth to meet the crew—and maybe reel in your own!

1 1

Vizgen @vizgen.bsky.social · Jun 5

Learn how combining MERSCOPE Ultra™ and InSituPlex® provides a more comprehensive view of immune infiltration, tumor biology, and spatial organization within human FFPE cancer samples. 

Download our #AACR25 Poster:
hubs.ly/Q03qzRMG0

1 2

Vizgen @vizgen.bsky.social · Jun 2

Vizgen is proud to be a silver sponsor for #HCA2025. ✨

Stop by booth #2 to meet the Vizgen team and explore our latest innovations in spatial multi-omics.

#SpatialBiology #SingleCell

1 1

Vizgen @vizgen.bsky.social · May 28

We’re headed to the 2025 WEHI Spatial Technology Symposium in Melbourne, June 5-6.

Join us and Integrated Sciences as we highlight the latest in spatial biology, including MERFISH 2.0™ and MERSCOPE Ultra™.

Register: www.eventbrite.com.au/e/wehi-spati...

#SpatialBiology #SpatialMultiOmics