When researching LongCOVID, we need to consider clinical impairment and the range of symptoms reported. 5/5

www.nature.com/articles/s43...

Reinfected children and young people had more symptoms than children and young people who report one infection; those who report no infection had the lowest symptom burden. 4/

They found that 7.2% of children and young people consistently meet the ‘Long COVID’ research definition at 3-, 6-, 12- and 24-months post-infection. These children and young people reported around 5-to-6 symptoms at each time-point. 3/

Researchers used data from the Long COVID in Children and Young People (CloCk) study to describe symptoms and how much they impact children and young people’s lives 24-months post-infection. 2/

Asthma attacks & COPD flare-ups (also called exacerbations) can be deadly. Every day in the UK four people with asthma & 85 people with COPD will tragically die. Both conditions are also very common. In the UK, someone has an asthma attack every 10 seconds 6/6

www.thelancet.com/journals/lan...

The benralizumab injection was administered by health care professionals in the study but can be potentially administered safely at home, in the GP practice, or in the Emergency Department. 5/

Benralizumab is a safe and effective drug already used to manage severe asthma. The researchers used the drug in a different way—at the point of an exacerbation—to show that it's more effective than steroid tablets, which is the only treatment currently available. 4/

Treatment with the #benralizumab injection took longer to fail, meaning fewer episodes to see a doctor or go to hospital. There was also an improvement in the quality of life for people with asthma and COPD. 3/

#Benralizumab is a monoclonal antibody which targets eosinophils to reduce lung inflammation. The new trial has found a single dose can be more effective when injected at the point of exacerbation compared to steroid tablets. 2/

Here is the link to the study👇

www.sciencedirect.com/science/arti...

Trans fats are preferred over Cis fats by SPT to synthesize long-chain sphingoid bases. Trans-fat-derived sphingomyelin is highly secreted from cells.
Trans fats promotes hepatic SPT flux, VLDL secretion & atherosclerosis. SPT inhibition reduces circulating VLDLs & atherosclerosis in mice 4/4

Here, using a combination of in vitro and in vivo metabolic tracing, dietary manipulations, pharmacological interventions, and physiological analyses, researchers have highlighted a functional role for serine palmitoyltransferase (SPT) in hepatic lipoprotein metabolism and ASCVD progression. 3/

Fortunately, this attention to cholesterol has prompted the development of cholesterol-lowering drugs called statins and lifestyle interventions like dietary and exercise regimens. But what if there's more to the picture than just cholesterol? 2/