wearnxin.bsky.social
Wearn Xin (Edeline)
@wearnxin.bsky.social
29 followers 28 following 3 posts
Postdoc at UCSF // PhD at Oxford Interested in pathogens, horizontal gene transfer and host-pathogen interactions :)
Posts Media Videos Starter Packs
wearnxin.bsky.social
Wearn Xin (Edeline) @wearnxin.bsky.social · Apr 4
Big thank you to @jbdsf.bsky.social and all our collaborators for this work! It's amazing how one nuclease can detect so many modifications!
jbdsf.bsky.social
Joe Bondy-Denomy @jbdsf.bsky.social · Apr 3
Interested in phage defenses that natively block lytic phage used in therapies?

Or do you want to figure out if a phage has a modified genome?

Meet the END-nucleases, an enzyme family that can broadly restrict phages with many diverse modifications. From talented post-doc Wearn-Xin Yee!
1
wearnxin.bsky.social
Wearn Xin (Edeline) @wearnxin.bsky.social · Apr 2
A big thank you to Joe for his guidance during this first postdoc publication and to everyone in the lab (inclu. ex-members!) for the experimental support; to Peter and Yan-Jiun, the DNA hypermodification experts; and of course Kira and Eugene, for the amazing domain analyses! I've learnt so much!
2
wearnxin.bsky.social
Wearn Xin (Edeline) @wearnxin.bsky.social · Apr 2
We've identified a group of nucleases that can target multiple phages with hypermodified DNA, using a sensor domain present across many domains of life. We’ve even used this as a tool to find phages with hypermodified DNA! Really thankful to all the co-authors who have been such great help!
END nucleases: Antiphage defense systems targeting multiple hypermodified phage genomes
Prokaryotes carry clusters of phage defense systems in defense islands that have been extensively exploited bioinformatically and experimentally for discovery of immune functions. However, little effo...
www.biorxiv.org
1 7 31