WesleyWongLab
@wesleywonglab.bsky.social
We study the physical basis behind how biological systems work at the nanoscale, focusing on the role of force, using single-molecule and nanoscale methods
https://www.wonglab.tch.harvard.edu
https://www.wonglab.tch.harvard.edu
Our light guided molecular patterning method for high-throughput single-molecule studies just published today in Small! Programmable, covalent, multiplexed, accessible.
doi.org/10.1002/smll...
doi.org/10.1002/smll...
Light‐Guided Molecular Patterning for High‐Throughput Single‐Molecule Mechanical Characterization
A light-guided molecular patterning method is presented for high-throughput single-molecule characterization. The approach enables scalable and accessible molecular patterning without specialized lit...
doi.org
January 19, 2026 at 8:10 PM
Our light guided molecular patterning method for high-throughput single-molecule studies just published today in Small! Programmable, covalent, multiplexed, accessible.
doi.org/10.1002/smll...
doi.org/10.1002/smll...
What better way to start the year then with a deep dive into multiplexed force spectroscopy? It was a lot of fun putting this together with @halvorsenlab.bsky.social. Hope you check it out!
Starting the new year with a review article! (with @wesleywonglab.bsky.social) This feels like a pretty big accomplishment. I remember how much I relied on annual reviews as a grad student to dive into a subject, so its surreal to be on the other side...
www.annualreviews.org/content/jour...
www.annualreviews.org/content/jour...
Beyond the Single Molecule: Multiplexed Methods in Force Spectroscopy
Single-molecule techniques have transformed biological research by enabling direct observation and manipulation of individual molecules. These methods overcome ensemble averaging inherent in bulk meas...
www.annualreviews.org
January 16, 2026 at 3:39 PM
What better way to start the year then with a deep dive into multiplexed force spectroscopy? It was a lot of fun putting this together with @halvorsenlab.bsky.social. Hope you check it out!
Our work on using DNA nanoswitches to characterize G-quadruplexes at the single-molecule level is now out in NAR!
In the recent publication in Nucleic Acids Research, we introduce a single-molecule framework that combines multiple distance measurements with directional mechanical unfolding, enabling simultaneous structural and mechanical fingerprinting of nucleic acids.
doi.org/10.1093/nar/...
doi.org/10.1093/nar/...
Single-molecule mechanostructural fingerprinting of nucleic acid conformations
Abstract. Understanding the three-dimensional structure and mechanical response of biomolecules is key to uncovering their molecular mechanisms, particular
doi.org
January 15, 2026 at 2:32 PM
Our work on using DNA nanoswitches to characterize G-quadruplexes at the single-molecule level is now out in NAR!
Just published in ACS Central Science—our latest work using the Centrifuge Force Microscope to quantify immune-cell interactions. The new setup combines high-throughput force spectroscopy with multichannel fluorescence for single-cell studies. pubs.acs.org/doi/10.1021/...
August 28, 2025 at 3:20 PM
Just published in ACS Central Science—our latest work using the Centrifuge Force Microscope to quantify immune-cell interactions. The new setup combines high-throughput force spectroscopy with multichannel fluorescence for single-cell studies. pubs.acs.org/doi/10.1021/...
New preprint on single-molecule mechanostructural fingerprinting! doi.org/10.1101/2025... We use DNA nanoswitch calipers to characterize the geometry and mechanical stability of telomeric DNA G-quadruplexes. #Biophysics #SingleMolecule #Mechanobiology #DNAnanotech
May 9, 2025 at 3:15 PM
New preprint on single-molecule mechanostructural fingerprinting! doi.org/10.1101/2025... We use DNA nanoswitch calipers to characterize the geometry and mechanical stability of telomeric DNA G-quadruplexes. #Biophysics #SingleMolecule #Mechanobiology #DNAnanotech
Excited to share our new preprint! It's a light-guided approach for precise and programmable molecular patterning, enabling multiplexed single-molecule force spectroscopy—no lithography needed. Read more at doi.org/10.1101/2025...
May 4, 2025 at 12:02 AM
Excited to share our new preprint! It's a light-guided approach for precise and programmable molecular patterning, enabling multiplexed single-molecule force spectroscopy—no lithography needed. Read more at doi.org/10.1101/2025...