Wills Barrell
@willsbarrell.bsky.social
Postdoc in the Liu lab, KCL. Dev bio, cilia, neural crest cells, congenital anomaly modelling
Reposted by Wills Barrell
Sequestration of Ena/VASP proteins impedes in vivo Wnt activation driving Xenopus embryonic development. Our results suggest Mena as a crucial mediator of Wnt signalosome endocytosis thus promoting canonical Wnt signalling.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
The Actin regulator Mena promotes Wnt signalosome endocytosis and Wnt signalling.
Wnt signaling controls embryonic development and tissue maintenance. Endocytosis of Wnt-receptors is required for signalling, yet uptake mechanisms remain poorly understood. Here, we identify the acti...
www.biorxiv.org
November 25, 2025 at 10:58 AM
Sequestration of Ena/VASP proteins impedes in vivo Wnt activation driving Xenopus embryonic development. Our results suggest Mena as a crucial mediator of Wnt signalosome endocytosis thus promoting canonical Wnt signalling.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...