William M de Souza
@wmdesouza.bsky.social
Assistant Professor at the University of Kentucky | Emerging Arboviruses | www.desouzalab.com
Chikungunya virus and other emerging arthritogenic alphaviruses. At @natrevmicro.nature.com we discuss the transmission dynamics, evolution, pathophysiology & countermeasures 🌎 🦟 🦠 🌡️
Read more ➡️ rdcu.be/ek1MD
Read more ➡️ rdcu.be/ek1MD
May 7, 2025 at 1:56 PM
Chikungunya virus and other emerging arthritogenic alphaviruses. At @natrevmicro.nature.com we discuss the transmission dynamics, evolution, pathophysiology & countermeasures 🌎 🦟 🦠 🌡️
Read more ➡️ rdcu.be/ek1MD
Read more ➡️ rdcu.be/ek1MD
Our study at @TheLancetInfDis demonstrated that 2023-24 Oropouche virus reassortant have increased virulence, fitness, and the ability to evade previous immunity generated by the previous Oropouche virus infection! 🦟🦠🇧🇷
Available:
thelancet.com/journals/lanin…
Available:
thelancet.com/journals/lanin…
February 20, 2025 at 3:39 PM
Our study at @TheLancetInfDis demonstrated that 2023-24 Oropouche virus reassortant have increased virulence, fitness, and the ability to evade previous immunity generated by the previous Oropouche virus infection! 🦟🦠🇧🇷
Available:
thelancet.com/journals/lanin…
Available:
thelancet.com/journals/lanin…
Our study at @EIDjournal investigates the molecular epidemiology of western equine encephalitis virus in South America between November 2023 and April 2024.🦟🐎🧠🇧🇷🇦🇷🇺🇾
Read:
wwwnc.cdc.gov/eid/article/30…
Read:
wwwnc.cdc.gov/eid/article/30…
February 20, 2025 at 3:39 PM
Our study at @EIDjournal investigates the molecular epidemiology of western equine encephalitis virus in South America between November 2023 and April 2024.🦟🐎🧠🇧🇷🇦🇷🇺🇾
Read:
wwwnc.cdc.gov/eid/article/30…
Read:
wwwnc.cdc.gov/eid/article/30…
We identified a novel Western equine encephalitis lineage associated with the ongoing outbreak in South America (2023-2024).
Great collaboration with @aascarpellini @Richardssalvato @GabrielWallau @jaderccardoso 🦟🦠🐎🇧🇷
x.com/Richardssalvat…
Great collaboration with @aascarpellini @Richardssalvato @GabrielWallau @jaderccardoso 🦟🦠🐎🇧🇷
x.com/Richardssalvat…
February 20, 2025 at 3:38 PM
We identified a novel Western equine encephalitis lineage associated with the ongoing outbreak in South America (2023-2024).
Great collaboration with @aascarpellini @Richardssalvato @GabrielWallau @jaderccardoso 🦟🦠🐎🇧🇷
x.com/Richardssalvat…
Great collaboration with @aascarpellini @Richardssalvato @GabrielWallau @jaderccardoso 🦟🦠🐎🇧🇷
x.com/Richardssalvat…
Mayaro virus found in 3.4% of febrile patients in Roraima, Brazil (2018-2021)! In our study at @EIDjournal we detected, sequenced, and isolated the Mayaro virus & confirmed genotype D.
Led by Júlia Forato and @LeveUnicamp team. 🦟🦠🇧🇷
Read:
wwwnc.cdc.gov/eid/article/30…
Led by Júlia Forato and @LeveUnicamp team. 🦟🦠🇧🇷
Read:
wwwnc.cdc.gov/eid/article/30…
February 20, 2025 at 3:38 PM
Mayaro virus found in 3.4% of febrile patients in Roraima, Brazil (2018-2021)! In our study at @EIDjournal we detected, sequenced, and isolated the Mayaro virus & confirmed genotype D.
Led by Júlia Forato and @LeveUnicamp team. 🦟🦠🇧🇷
Read:
wwwnc.cdc.gov/eid/article/30…
Led by Júlia Forato and @LeveUnicamp team. 🦟🦠🇧🇷
Read:
wwwnc.cdc.gov/eid/article/30…
Join our team as a Research Associate or Postdoctoral Researcher. We work on preparedness and response for outbreaks and epidemics caused by emerging RNA viruses. Please apply, retweet, or share it. 🦠🦟🖥️📊
Apply now!
desouzalab.com/careers/
Apply now!
desouzalab.com/careers/
February 20, 2025 at 3:38 PM
Join our team as a Research Associate or Postdoctoral Researcher. We work on preparedness and response for outbreaks and epidemics caused by emerging RNA viruses. Please apply, retweet, or share it. 🦠🦟🖥️📊
Apply now!
desouzalab.com/careers/
Apply now!
desouzalab.com/careers/
I’m thrilled to announce that I am joining the Department of Microbiology, Immunology & Molecular Genetics @universityofky as Assistant Professor! My lab and I will continue to study emerging viruses and arboviruses🦠🦟
Check outcreated by @PlotMyScience
desouzalab.com
Check outcreated by @PlotMyScience
desouzalab.com
February 20, 2025 at 3:38 PM
I’m thrilled to announce that I am joining the Department of Microbiology, Immunology & Molecular Genetics @universityofky as Assistant Professor! My lab and I will continue to study emerging viruses and arboviruses🦠🦟
Check outcreated by @PlotMyScience
desouzalab.com
Check outcreated by @PlotMyScience
desouzalab.com
At @NatureComms, we showed the kinetics of the humoral response to homologous or heterologous COVID-19 vaccines in Syrian hamsters for up to 9 months.💉🦠🐹
Led by Rafael Machado and a great team!!! @utmbhealth @UTMB_WRCEVA
Available on:
doi.org/10.1038/s41467…
Led by Rafael Machado and a great team!!! @utmbhealth @UTMB_WRCEVA
Available on:
doi.org/10.1038/s41467…
February 20, 2025 at 3:38 PM
At @NatureComms, we showed the kinetics of the humoral response to homologous or heterologous COVID-19 vaccines in Syrian hamsters for up to 9 months.💉🦠🐹
Led by Rafael Machado and a great team!!! @utmbhealth @UTMB_WRCEVA
Available on:
doi.org/10.1038/s41467…
Led by Rafael Machado and a great team!!! @utmbhealth @UTMB_WRCEVA
Available on:
doi.org/10.1038/s41467…
We are delighted to share our study "Spatiotemporal dynamics and recurrence of chikungunya virus in Brazil: an epidemiological study" now published at
@LancetMicrobe!🦟🦠🇧🇷
Available:
thelancet.com/journals/lanmi…
@LancetMicrobe!🦟🦠🇧🇷
Available:
thelancet.com/journals/lanmi…
February 20, 2025 at 3:37 PM
We are delighted to share our study "Spatiotemporal dynamics and recurrence of chikungunya virus in Brazil: an epidemiological study" now published at
@LancetMicrobe!🦟🦠🇧🇷
Available:
thelancet.com/journals/lanmi…
@LancetMicrobe!🦟🦠🇧🇷
Available:
thelancet.com/journals/lanmi…
I am glad to be attending #TropMed2022 and meeting many new and old friends. Also, I am honored to be awarded as ASTMH Young Investigator Award - First-Tier Mention. @ASTMH @ACAV_ASTMH @GlobalVirusNews @UTMBGSBS 🦟🦠🏆
February 20, 2025 at 3:37 PM
I am glad to be attending #TropMed2022 and meeting many new and old friends. Also, I am honored to be awarded as ASTMH Young Investigator Award - First-Tier Mention. @ASTMH @ACAV_ASTMH @GlobalVirusNews @UTMBGSBS 🦟🦠🏆
We found that CHIKV can cause explosive outbreaks with a higher number of cases and deaths that is compared to dengue virus. We estimated the case-fatality ratio in Ceará at ~1.3 deaths per 1,000 cases
February 20, 2025 at 3:37 PM
We found that CHIKV can cause explosive outbreaks with a higher number of cases and deaths that is compared to dengue virus. We estimated the case-fatality ratio in Ceará at ~1.3 deaths per 1,000 cases
CHIKF recurrence in Brazil was associated with viral transmission in regions and municipalities less affected in previous waves, suggesting that spatial heterogeneity of CHIKV spread and population immunity may explain the recurrence pattern in the country
February 20, 2025 at 3:37 PM
CHIKF recurrence in Brazil was associated with viral transmission in regions and municipalities less affected in previous waves, suggesting that spatial heterogeneity of CHIKV spread and population immunity may explain the recurrence pattern in the country
Ceará State in the northeast has been the most affected, with two largest epidemic waves in 2016 and 2017, and the ongoing third wave in 2022. CHIKF disproportionally affected females.
February 20, 2025 at 3:37 PM
Ceará State in the northeast has been the most affected, with two largest epidemic waves in 2016 and 2017, and the ongoing third wave in 2022. CHIKF disproportionally affected females.
In the first part, we described the spatial-temporal dynamics of seven CHIKV epidemic waves across Brazil between 2013 and 2022 in Brazil, which affected 59.5% (3,316 of 5,570) of the country’s municipalities.
February 20, 2025 at 3:36 PM
In the first part, we described the spatial-temporal dynamics of seven CHIKV epidemic waves across Brazil between 2013 and 2022 in Brazil, which affected 59.5% (3,316 of 5,570) of the country’s municipalities.
CHIKF outbreak recurrences can be explained by several factors, including the absence of neutralizing antibodies in younger age groups after periods of epidemiological silence
February 20, 2025 at 3:36 PM
CHIKF outbreak recurrences can be explained by several factors, including the absence of neutralizing antibodies in younger age groups after periods of epidemiological silence
Our recent study led by @j_fumagalli shows how pre-existing immunity to chikungunya virus may affect secondary infection by Mayaro virus! Excellent team! @luizacjorge @deCarvalhoRenan @italoacastro @ZamboniLab @JVirology
Available at:
x.com/MJ_Fumagalli/s… journals.asm.org/doi/10.1128/JV…
Available at:
x.com/MJ_Fumagalli/s… journals.asm.org/doi/10.1128/JV…
February 20, 2025 at 3:36 PM
Our recent study led by @j_fumagalli shows how pre-existing immunity to chikungunya virus may affect secondary infection by Mayaro virus! Excellent team! @luizacjorge @deCarvalhoRenan @italoacastro @ZamboniLab @JVirology
Available at:
x.com/MJ_Fumagalli/s… journals.asm.org/doi/10.1128/JV…
Available at:
x.com/MJ_Fumagalli/s… journals.asm.org/doi/10.1128/JV…
I am really proud to be part of this great team!
@Paleovirologist @cggbamford @RhysHParry.
(i) Flaviviridae is at least 100 million years old! 🦖+🦠
(ii) ‘Classical’ flaviviruses first evolved from tick-specific viruses, and only later adapted to become insect-borne!🕷️ 🔜🦟
x.com/cggbamford/sta…
@Paleovirologist @cggbamford @RhysHParry.
(i) Flaviviridae is at least 100 million years old! 🦖+🦠
(ii) ‘Classical’ flaviviruses first evolved from tick-specific viruses, and only later adapted to become insect-borne!🕷️ 🔜🦟
x.com/cggbamford/sta…
February 20, 2025 at 3:36 PM
I am really proud to be part of this great team!
@Paleovirologist @cggbamford @RhysHParry.
(i) Flaviviridae is at least 100 million years old! 🦖+🦠
(ii) ‘Classical’ flaviviruses first evolved from tick-specific viruses, and only later adapted to become insect-borne!🕷️ 🔜🦟
x.com/cggbamford/sta…
@Paleovirologist @cggbamford @RhysHParry.
(i) Flaviviridae is at least 100 million years old! 🦖+🦠
(ii) ‘Classical’ flaviviruses first evolved from tick-specific viruses, and only later adapted to become insect-borne!🕷️ 🔜🦟
x.com/cggbamford/sta…
Our recent study discovered and characterized 3 novel paramyxoviruses from neotropical bats and suggest a novel genus and nephrotropism🦇🦠🌿@j_fumagalli @JeanCarrPaul @nmrfaria @PabloRMurcia
Available:
sciencedirect.com/science/articl…
Available:
sciencedirect.com/science/articl…
February 20, 2025 at 3:36 PM
Our recent study discovered and characterized 3 novel paramyxoviruses from neotropical bats and suggest a novel genus and nephrotropism🦇🦠🌿@j_fumagalli @JeanCarrPaul @nmrfaria @PabloRMurcia
Available:
sciencedirect.com/science/articl…
Available:
sciencedirect.com/science/articl…
Our recent work described Chikungunya causing fatal CNS infection. CHIKV can cause death by multiple organ failure, even in young and healthy @CaddeProject @nmrfaria @candido_darlan @j_fumagalli @JeanCarrPaul @marcionunesbra2 @IDSAInfo
academic.oup.com/cid/advance-ar…
academic.oup.com/cid/advance-ar…
February 20, 2025 at 3:36 PM
Our recent work described Chikungunya causing fatal CNS infection. CHIKV can cause death by multiple organ failure, even in young and healthy @CaddeProject @nmrfaria @candido_darlan @j_fumagalli @JeanCarrPaul @marcionunesbra2 @IDSAInfo
academic.oup.com/cid/advance-ar…
academic.oup.com/cid/advance-ar…