XavLoy
@xavloy.bsky.social
EVologist- Interested in CVD and Extracellular Vesicles - Paris -
Views are my own
Views are my own
Reposted by XavLoy
A Eichmann and Colleagues @PARCC showed that endothelial ROCK1 and 2 maintain junctional integrity and ensure proper angiogenesis and lumen formation. These data also indicate the need for careful consideration when using ROCK inhibitors in disease settings.
doi.org/10.1093/cvr/...
doi.org/10.1093/cvr/...
Endothelial Rho kinase controls blood vessel integrity and angiogenesis
AbstractAims. The Rho kinases 1 and 2 (ROCK1/2) are serine-threonine specific protein kinases that control actin cytoskeleton dynamics. They are expressed
doi.org
December 18, 2025 at 11:11 AM
A Eichmann and Colleagues @PARCC showed that endothelial ROCK1 and 2 maintain junctional integrity and ensure proper angiogenesis and lumen formation. These data also indicate the need for careful consideration when using ROCK inhibitors in disease settings.
doi.org/10.1093/cvr/...
doi.org/10.1093/cvr/...
Reposted by XavLoy
Pr Z Mallat @PARCC and colleagues show that, in patients with acute coronary syndromes, low-dose IL-2 safely increases Treg cell levels and reduces arterial inflammation.
Learn More: www.nature.com/articles/s41...
Learn More: www.nature.com/articles/s41...
Anti-inflammatory therapy with low-dose IL-2 in acute coronary syndromes: a randomized phase 2 trial - Nature Medicine
In a randomized phase 2 trial in patients with acute coronary syndrome and high levels of the inflammation biomarker C-reactive protein, treatment with low-dose interleukin-2 increased the numbers of ...
www.nature.com
January 8, 2026 at 1:56 PM
Pr Z Mallat @PARCC and colleagues show that, in patients with acute coronary syndromes, low-dose IL-2 safely increases Treg cell levels and reduces arterial inflammation.
Learn More: www.nature.com/articles/s41...
Learn More: www.nature.com/articles/s41...
Reposted by XavLoy
Dr E Camerer and colleagues @PARCC uncover an essential role for circulating S1P in maintaining blood pressure and left ventricular systolic function. They also highlight distinct functions for the pools of S1P bound to HDL or to albumin.
www.pnas.org/doi/10.1073/...
www.pnas.org/doi/10.1073/...
PNAS
Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...
www.pnas.org
January 10, 2026 at 1:46 PM
Dr E Camerer and colleagues @PARCC uncover an essential role for circulating S1P in maintaining blood pressure and left ventricular systolic function. They also highlight distinct functions for the pools of S1P bound to HDL or to albumin.
www.pnas.org/doi/10.1073/...
www.pnas.org/doi/10.1073/...
Reposted by XavLoy
In this Communications Biology article, authors modeled cardiomyocyte geometry revealing that mitochondrial–sarcoplasmic architecture enhances respiration by facilitating ion and lipid transfer for efficient cardiac metabolism🫀
@parcc-inserm.bsky.social
doi.org/10.1038/s420...
@parcc-inserm.bsky.social
doi.org/10.1038/s420...
Myocardial disarray drives metabolic inefficiency in human cardiomyocytes - Communications Biology
Modelling cardiomyocyte geometry reveals that mitochondrial–sarcoplasmic architecture enhances respiration by facilitating ion and lipid transfer for efficient cardiac metabolism.
doi.org
October 15, 2025 at 6:54 AM
In this Communications Biology article, authors modeled cardiomyocyte geometry revealing that mitochondrial–sarcoplasmic architecture enhances respiration by facilitating ion and lipid transfer for efficient cardiac metabolism🫀
@parcc-inserm.bsky.social
doi.org/10.1038/s420...
@parcc-inserm.bsky.social
doi.org/10.1038/s420...
Reposted by XavLoy
P Breillat and B Terrier from PL Tharaux team @PARCC showed that NK-cell dysfunction in VEXAS (vacuoles, E1 enzyme, X-linked, autoinflammatory, somatic) syndrome contributes to increased susceptibility to severe infections.
doi.org/10.1182/bloo...
doi.org/10.1182/bloo...
Impaired cytotoxic function and exhausted phenotype of natural killer cells in VEXAS syndrome
Key PointsNK-cell phenotyping reveals impaired cytotoxicity, chronic activation, and exhaustion in VEXAS syndrome.Decreased circulating NK cells were indep
doi.org
October 22, 2025 at 4:02 PM
P Breillat and B Terrier from PL Tharaux team @PARCC showed that NK-cell dysfunction in VEXAS (vacuoles, E1 enzyme, X-linked, autoinflammatory, somatic) syndrome contributes to increased susceptibility to severe infections.
doi.org/10.1182/bloo...
doi.org/10.1182/bloo...
Reposted by XavLoy
🚨 New paper from the lab in ATVB
Dexamethasone protects against COVID-19 endothelium-induced coagulopathy 🦠🔥🫁🩸
@davidmsmadja.bsky.social @hopitalpompidou.bsky.social @upcite.bsky.social @parcc-inserm.bsky.social
@ahajournals.bsky.social
@inserm.fr
www.ahajournals.org/doi/10.1161/...
Dexamethasone protects against COVID-19 endothelium-induced coagulopathy 🦠🔥🫁🩸
@davidmsmadja.bsky.social @hopitalpompidou.bsky.social @upcite.bsky.social @parcc-inserm.bsky.social
@ahajournals.bsky.social
@inserm.fr
www.ahajournals.org/doi/10.1161/...
Dexamethasone Suppresses Endotheliopathy and Endothelial-Induced Coagulopathy in COVID-19 | Arteriosclerosis, Thrombosis, and Vascular Biology
BACKGROUND: Endotheliopathy and coagulopathy are known complications of COVID-19, with a significant
association with mortality. Although dexamethasone is the standard of care for patients
with severe...
www.ahajournals.org
October 2, 2025 at 11:49 AM
🚨 New paper from the lab in ATVB
Dexamethasone protects against COVID-19 endothelium-induced coagulopathy 🦠🔥🫁🩸
@davidmsmadja.bsky.social @hopitalpompidou.bsky.social @upcite.bsky.social @parcc-inserm.bsky.social
@ahajournals.bsky.social
@inserm.fr
www.ahajournals.org/doi/10.1161/...
Dexamethasone protects against COVID-19 endothelium-induced coagulopathy 🦠🔥🫁🩸
@davidmsmadja.bsky.social @hopitalpompidou.bsky.social @upcite.bsky.social @parcc-inserm.bsky.social
@ahajournals.bsky.social
@inserm.fr
www.ahajournals.org/doi/10.1161/...
Reposted by XavLoy
Pr JS Hulot team @PARCC revealed that CD51 contributes to the immune-fibrotic axis driving heart failure progression under pressure overload.
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Inhibition of integrin alpha V reduces inflammation and the transition to heart failure after pressure overload
Integrin alpha V (CD51) is a surface receptor that binds to extracellular matrix ligands and contributes to fibrotic responses, including post-infarct…
www.sciencedirect.com
October 6, 2025 at 4:36 PM
Pr JS Hulot team @PARCC revealed that CD51 contributes to the immune-fibrotic axis driving heart failure progression under pressure overload.
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
#VEXAS Syndrome new paper alert!!
October 7, 2025 at 2:04 PM
#VEXAS Syndrome new paper alert!!
Reposted by XavLoy
Reposted by XavLoy
Collaborative work from E Camerer @PARCC highlights S1PR1 as a new regulator of both lymphatic valves and tertiary lymphoid organs (TLOs), and suggests that TLOs could be a marker for underlying lymphatic disorders.
doi.org/10.1084/jem....
doi.org/10.1084/jem....
S1PR1 regulates lymphatic valve development and tertiary lymphoid organ formation in the ileum | Journal of Experimental Medicine | Rockefeller University Press
TLOs are LN-like structures that are observed in certain inflammatory diseases. Geng et al. demonstrate that S1PR1 activity in the lymphatic vasculature is
doi.org
September 2, 2025 at 9:52 AM
Collaborative work from E Camerer @PARCC highlights S1PR1 as a new regulator of both lymphatic valves and tertiary lymphoid organs (TLOs), and suggests that TLOs could be a marker for underlying lymphatic disorders.
doi.org/10.1084/jem....
doi.org/10.1084/jem....
Reposted by XavLoy
C Cochain and coworkers @PARCC reveal that platelets interact with macrophages in the ischemic heart, and this interaction causes macrophages to become proinflammatory.
academic.oup.com/jleukbio/art...
academic.oup.com/jleukbio/art...
Platelets drive macrophage inflammatory activation in vitro
Activated platelets drive the inflammatory activation of macrophages mainly via cell-contact dependent mechanisms.
academic.oup.com
September 2, 2025 at 9:44 AM
C Cochain and coworkers @PARCC reveal that platelets interact with macrophages in the ischemic heart, and this interaction causes macrophages to become proinflammatory.
academic.oup.com/jleukbio/art...
academic.oup.com/jleukbio/art...
April 22, 2025 at 5:11 PM
Reposted by XavLoy
Dans l'académie de Normandie, en 7 mois, 9 enseignants se sont suicidés et 3 ont tenté de mettre fin à leurs jours.
"Jamais les registres de santé et sécurité au travail n’ont autant enregistré de signalements et d’appels à l’aide", alerte la FSU www.ouest-france.fr/education/en... @ouest-france.fr
"Jamais les registres de santé et sécurité au travail n’ont autant enregistré de signalements et d’appels à l’aide", alerte la FSU www.ouest-france.fr/education/en... @ouest-france.fr
Suicides dans l’académie de Normandie : un syndicat alerte
Selon la FSU Normandie, neuf enseignants se sont suicidés depuis juin 2024. Le syndicat demande au rectorat de réagir.
www.ouest-france.fr
January 25, 2025 at 9:23 AM
Dans l'académie de Normandie, en 7 mois, 9 enseignants se sont suicidés et 3 ont tenté de mettre fin à leurs jours.
"Jamais les registres de santé et sécurité au travail n’ont autant enregistré de signalements et d’appels à l’aide", alerte la FSU www.ouest-france.fr/education/en... @ouest-france.fr
"Jamais les registres de santé et sécurité au travail n’ont autant enregistré de signalements et d’appels à l’aide", alerte la FSU www.ouest-france.fr/education/en... @ouest-france.fr