Lightnews — Scholar-powered news

Xin Xiang @xianglab.bsky.social · Jun 2

I had fun checking out the endomap site (endomap.hms.harvard.edu/network). Surprisingly, PRPF40A (pre-mRNA splicing, Huntingtin-interacting, Aspergillus homolog Prp40A involved in cytoplasmic dynein function) connects to axonemal dynein light intermediate chain polypeptide, which is interesting!

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Xin Xiang @xianglab.bsky.social · May 24

www.dha.mil/News/2025/05...
Very proud of my colleague @pskcellbio.bsky.social and her lab for this important work on the clearance of misfolded GPI-anchor proteins out of the ER (supported by the NIH)!

journals.plos.org/plosbiology/...

www.dha.mil

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Xin Xiang @xianglab.bsky.social · Apr 29

Thank you Ferdos!

Reposted by Xin Xiang

John Salogiannis @jsalogiannis.bsky.social · Apr 24

Preprint from our lab is out! We identified a peroxisome-localized acyl-coA binding protein AcbdA - that regulates peroxisome movement. www.biorxiv.org/content/10.1.... Congratulations to members of my lab and the Christensen lab
@christensenlab.bsky.social www.biorxiv.org/content/10.1...

Acyl-coA binding protein AcbdA regulates peroxisome hitchhiking on early endosomes

Motor-driven transport on microtubules is critical for distributing organelles throughout the cell. Most commonly, organelle movement is mediated by cargo adaptors, proteins on the surface of an organ...

www.biorxiv.org

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Xin Xiang @xianglab.bsky.social · Apr 27

Beautiful work! Aside from the motor cooperation theme, this paper shows an insightful structure of the FHF complex (initially isolated by Wade Harper lab at Harvard. Xu et al 2008 MBoC). The structure contains FTS, the C-terminal part of Hook3 and FHIP1B. What a journey! Congrats to Abid Ali et al!

Ferdos Abid Ali @abidalilab.bsky.social · Apr 24

Great to see our story on dynein & kinesin co-dependence published www.nature.com/articles/s41..., and absolutely chuffed that it's made the front cover (thanks NSMB!). A brilliant News & Views too by Steven Markus www.nature.com/articles/s41.... Collab between @carter-lab.bsky.social & Straube lab🔬

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Reposted by Xin Xiang

Juan S. Bonifacino @juanbonifacino.bsky.social · Apr 13

Our lab at the NIH (Bethesda, MD) is looking for postdoctoral fellows to join our team studying the molecular mechanisms of protein trafficking and their links to neurodevelopmental disorders starting on or after 10-1-2025. Send your application to [email protected]. Please share and repost!

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Xin Xiang @xianglab.bsky.social · Apr 11

Thank you so much Prasanna!

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Xin Xiang @xianglab.bsky.social · Apr 10

Happy to share this short spotlight piece kwnsfk27.r.eu-west-1.awstrack.me/L0/https:%2F... published online by @cp-trendscellbio.bsky.social
for an interesting paper about an unexpected mechanism behind Kinesin-1-mediated meiotic spindle positioning in C. elegans @cp-cellreports.bsky.social

kwnsfk27.r.eu-west-1.awstrack.me

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Xin Xiang @xianglab.bsky.social · Mar 20

Wow! Congratulations!

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Xin Xiang @xianglab.bsky.social · Mar 18

LC8 moonlighting (most likely) in channels. Nice work!

Colin Nichols Lab @colinnicholslab.bsky.social · Mar 15

Check out our new publication "Dynein light chains 1 and 2 are auxiliary proteins of pH-sensitive Kir4.1 channels"
www.sciencedirect.com/science/arti...
A 🧵 1/n

Dynein light chains 1 and 2 are auxiliary proteins of pH-sensitive Kir4.1 channels

Inward rectifier Kir4.1 potassium channels are abundantly expressed in cells that are important for electrolyte homeostasis. Dysregulation of Kir4.1 u…

www.sciencedirect.com

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Xin Xiang @xianglab.bsky.social · Mar 9

An interesting read. Neil Gow just gave a fantastic talk at the #ecfg17 on fungal cell wall components- on mannose polymers that can either be a flag or a mask for different immune cells. The part on the malaria parasite is also fascinating.

Neil Gow @neil-gow.bsky.social · Dec 16

I was j reviewed, along with other microbiologists. on how microbes disguise themselves from our immune systems. The article is out in The Scientist. www.the-scientist.com/the-art-of-m...

The Art of Microbial Disguise

On the battleground of the human body, microbes use every skill to mask, infiltrate, manipulate, and evade the immune radar.

www.the-scientist.com

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Xin Xiang @xianglab.bsky.social · Mar 7

Just learned about this amazing work! doi.org/10.1016/j.cub.2024.12.041

Redirecting

doi.org

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Reposted by Xin Xiang

Carter Lab @carter-lab.bsky.social · Feb 21

Today in #journalclub, we looked at this fantastic new method from the @doudna-lab.bsky.social in Nature Biotechnology! They show how CRISPR–Csm enables single-molecule live-cell imaging of endogenous RNAs. Super cool!
www.nature.com/articles/s41...

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Reposted by Xin Xiang

Miguel A. Peñalva @miguelpenalva.bsky.social · Feb 16

our first serious attempt to understand F-actin (F standing for filamentous, among other things) in Aspergillus nidulans: www.biorxiv.org/content/10.1...

The actin module of endocytic internalization in Aspergillus nidulans: a critical role of the WISH/DIP/SPIN90 family protein Dip1

Using FPs fused with actin or its fiduciary probes Lifeact, Chromobody and Tractin, we studied, by time-resolved microscopy, the actin module of endocytosis in Aspergillus nidulans. F-actin probes eff...

www.biorxiv.org

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Reposted by Xin Xiang

Matthias C. Rillig @mrillig.bsky.social · Feb 6

Review in Nature

Case et al.
Fungal impacts on Earth’s ecosystems

www.nature.com/articles/s41...

Fungal impacts on Earth’s ecosystems - Nature

This Review delves into the fungal kingdom, exploring the relationships among fungi, animals, plants and the environment, and investigating both the threats posed by fungi and their potential benefits...

www.nature.com

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Xin Xiang @xianglab.bsky.social · Feb 6

Interesting! I guess they may still have it to get rid of lactic acid produced in muscle.

Reposted by Xin Xiang

Samara Reck-Peterson @samreckpeterson.bsky.social · Jan 31

I am excited for this opportunity to chair the Department of Biochemistry and Biophysics at Weill Cornell Medicine! news.weill.cornell.edu/news/2025/01...

Dr. Samara Reck-Peterson Named Chair of the Department of Biochemistry and Biophysics at Weill Cornell Medicine

The newly configured department marshals biochemists, biophysicists and experts in protein engineering and imaging to drive discoveries in the basic mechanisms of cell function.

news.weill.cornell.edu

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Reposted by Xin Xiang

Samara Reck-Peterson @samreckpeterson.bsky.social · Jan 20

The deadline to attend the “Integrating cell and planetary scales to address climate resilience” EMBO meeting is Feb 1st! We are bringing together scientists, funders, and policy makers. Join us for this exciting meeting: meetings.embo.org/event/25-cli...

Integrating cell and planetary scales to address climate resilience

The climate crisis is a multiscale problem that requires transdisciplinary expertise for understanding and engineering climate resilience. Cells are the first responders of the biosphere and yet cell…

meetings.embo.org

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Xin Xiang @xianglab.bsky.social · Jan 18

This is such a sad news! I remember talking to him at meetings many years ago and learning about the Rab11-centrosome connection…

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Reposted by Xin Xiang

Marco Hein @marco.heinlab.org · Jan 14

Time to share our organelle proteome paper
out in @cellcellpress.bsky.social: doi.org/nzwz
We created a spatial map of human cells using organelle immunoprecipitation at scale.
Locate your fav protein among the 7,600 we mapped across 19 subcellular compartments: organelles.sf.czbiohub.org/

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Graphical abstract of the Organelle Profiling paper, showing the workflow:
Endogenously tagged organelle library;
Native IP proteomics;
Data-driven graph clustering;
resulting in a subcellular proteome map with
more than 7,600 proteins localized across 19 subcellular compartments.

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Reposted by Xin Xiang

Darren Thomson @darrenthomson.bsky.social · Jan 3

I'm looking to database organelle dyes which work in fungi. Please comment if you can contribute w/ details.

We regularly see @mrccmm.bsky.social that some don't work in some fungi, but I just don't think it's been tested properly #Mycoscopy

I started this w/ Alex Lichius years ago, tip of the 🧊!

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Xin Xiang @xianglab.bsky.social · Jan 4

fusions in Aspergillus nidulans from different labs: Sec63-mRFP or Sec63-GFP labeling ER (Peñalva); GFP-RabE(Rab11) labeling post-Golgi vesicles (Peñalva); An-Nup49-GFP (and more) for nuclear pores (Osmani); PexK-GFP for peroxisomes (Hynes; Reck-Peterson) etc.

Reposted by Xin Xiang

Rui Zhang @ruizhangmt.bsky.social · Jan 1

Best way to start 2025! Thrilled to share our Nature paper about the structures of axonemal components from sperm flagella and from epithelial cilia of the oviduct and brain ventricles. Great collaboration with Tzviya Zeev-Ben-Mordehai and @alanbrownhms.bsky.social

www.nature.com/articles/s41...

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Reposted by Xin Xiang

Simon Bullock @simonbullock11.bsky.social · Dec 12

This is an great opportunity. Andrew, his science, and his team are amazing!

MRC Laboratory of Molecular Biology @mrclmb.bsky.social · Dec 12

Exciting 3-year postdoc opportunity with @carter-lab.bsky.social within a programme aimed at identifying the links between microtubule motors and axonal cargos.
Read more about the role here:
www.nature.com/naturecareer...
Apply by 30 DEC
#ScienceJobs #CambridgeJobs #PostdocJobs #GenomeEngineering

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Xin Xiang @xianglab.bsky.social · Dec 12

A very cool study revealing an important role of Fragile X messenger ribonucleoprotein (FMRP) in the local translation of a mitochondrial fission protein near its site of action. It really enhanced the understanding of the disease mechanism of Fragile X syndrome. Congratulations to all authors!

PennMedCSO @pennmedcso.bsky.social · Dec 11

FMRP, MFF translation & mitochondrial fission in neurons ft. Adam Fenton, Ruchao Peng, @Charlie_R_Bond, @SHugelier, @melikel.bsky.social, @yiweichang.bsky.social, @erikaholzbaur.bsky.social & Thomas Jongens @BB_UPenn @penngenetics.bsky.social @cambupenn.bsky.social www.nature.com/articles/s41...

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