Lightnews — Scholar-powered news

Reposted by Simon Bullock

Alfredo Castello @alf-castello.bsky.social · 6d

Are you thinking on an exciting PHD project at the interface of translation control and innate immunity? @rnanomad.bsky.social and I have a project that might interest you!

Mehdi Jafarnejad @rnanomad.bsky.social · 6d

@alf-castello.bsky.social & I are inviting applications for a competitive PhD studentship to study the mechanisms of translational regulation of the host response to RNA virus infections. The student will be based at Uni. Glasgow. Please spread the word. #RNASky

www.gla.ac.uk/postgraduate...

University of Glasgow - Postgraduate study - Centres for Doctoral Training - NorthWest Biosciences - Our Projects - Understanding Pathogens, from Molecules to Phenotypes - Alfredo Castello

www.gla.ac.uk

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Reposted by Simon Bullock

Michael Webster @michaelwebster.bsky.social · 6d

Start independent research at the JIC with us 👇.

Really interested in finding those with an interest in structural biology and biochemistry of plants and microbes.

Please do get in touch by email if you'd like to know more 👍

John Innes Centre @johninnescentre.bsky.social · 6d

VACANCY - Independent research fellowships leading to tenured positions

We’re inviting applications from outstanding researchers who either hold, or wish to apply for, Independent Research Fellowships.

APPLICATION DEADLINE: 10 November 2025

Click here to apply: jic.link/Fellows

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Reposted by Simon Bullock

Siân Culley @superresolusian.bsky.social · 10d

BioImage analysis friends - King's are recruiting for a full-time, permanent facility position! Come and work with fun microscopes and fun people (and me!) - please share! www.kcl.ac.uk/jobs/126345-...

Bioimage Analysis Specialist | King's College London

www.kcl.ac.uk

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Sofya Garushyants @garushyants.bsky.social · 24d

hey bluesky 👋 visa hurdles mean I’m looking for opportunities outside the US. I’m a computational biologist (bacterial + phage genomics, postdoc in Koonin’s group @ NIH). I am interested in teaming up on funding apps. reach out if this resonates!

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Michael Way @drmichaelway.bsky.social · 23d

And now for something completely different @tianyang22.bsky.social & #YanCao uncover of how SPIN90 dimers activate Arp2/3 to nucleate bidirectional linear actin filaments. Great collaboration with @romet-jegou-lab.bsky.social & @carolynmoores1.bsky.social #Cryo-EM #Arp2/3 rdcu.be/eGoH4

Arp2/3-mediated bidirectional actin assembly by SPIN90 dimers

Nature Structural & Molecular Biology - Liu et al. show that SPIN90 dimerizes and binds two Arp2/3 complexes to nucleate two bidirectional actin filaments and the dimerization domain is...

rdcu.be

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Reposted by Simon Bullock

Akaash Kumar @akaashkumar.bsky.social · 23d

🚨Publication alert🚨
My first, first-author paper is now out in @natphoton.nature.com! Our paper describes an iterative spectral unmixing algorithm and eight-channel camera-based hardware we developed enabling unmixing of low SNR live-cell data at video rates. www.nature.com/articles/s41...

Multispectral live-cell imaging with uncompromised spatiotemporal resolution - Nature Photonics

A tree-like arrangement of dichroic mirrors and multiple cameras coupled with an iterative spectral unmixing algorithm enables multispectral imaging of live cells in up to eight spectral channels with...

www.nature.com

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Reposted by Simon Bullock

EMBL Events @events.embl.org · 28d

Are you ready for a symposium dedicated to microtubule dynamics, function, and structure? 🙌

#EESMicrotubules will bring together researchers who share an interest in microtubule biology and its relevance to health and disease 🩺

💻 s.embl.org/ees26-09-bl
✒️ Submit your abstract by 11 March

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Reposted by Simon Bullock

Anestis Tsakiridis @tsakiridis.bsky.social · 28d

A 6-month postdoc position is currently available in our group. The project involves the use of hPSC-based models to dissect the links between chromosomal copy number alterations, DNA damage and tumour initiation-please spread the word-closing date=29th Sept: www.jobs.ac.uk/job/DON353/r...

Research Associate (Stem Cell/Cancer Biology)

jobsite.sheffield.ac.uk

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Simon Bullock @simonbullock11.bsky.social · 29d

The winners of our schools microscopy competition have been announced 👇!

MRC Laboratory of Molecular Biology @mrclmb.bsky.social · 29d

🔬 Over 900 pupils from 22 schools across Cambridge, Peterborough & Bedfordshire took part in this year’s #Microscopes4Schools competition.

From insect wings to iridescent feathers, kids used microscopes to explore the hidden beauty of nature: www2.mrc-lmb.cam.ac.uk/microscopes-...

#LMBNews

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Reposted by Simon Bullock

News from UK Research and Innovation @news.ukri.org · Sep 9

ICYMI: Simplifying access to MRC applicant-led funding #MRC #AcademicSky

Simplifying access to MRC applicant-led funding

We’re introducing a new flexible research grant and removing closing dates from our board funding opportunities.

www.ukri.org

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Reposted by Simon Bullock

Marco MILAN LAB @milanlab.bsky.social · Sep 4

EMBO meeting on "Molecular and Developmental Biology of Drosophila" 21 – 27 June 2026
Registration is now open!
Deadline next November 3rd!
meetings.embo.org/event/26-dro...

Molecular and Developmental Biology of Drosophila

The principal theme of the EMBO Workshop is the Molecular and Developmental Biology of Drosophila. Supported by EMBO over four decades, this will be the 24th biennial “Crete meeting”. With the a…

meetings.embo.org

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Katja Röper @katjaroeper.bsky.social · Sep 3

If you love cytoskeleton and tissue morphogenesis, have a read!

Development @dev-journal.bsky.social · Sep 1

Supracellular actomyosin assemblies: master coordinators of development

In this Review, Katja Röper @katjaroeper.bsky.social discusses supracellular actomyosin structures, tissues where they function, their known roles as well as potential properties

journals.biologists.com/dev/article/...

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Reposted by Simon Bullock

Matthew Freeman @mjafreeman.bsky.social · Sep 1

Are you a postdoc interested in the mechanisms of disease?

Do you have a great record and an exciting vision?

Come and start your own lab @dunnschool.bsky.social by applying for sponsorship for early career fellowships.

Deadline 30th September...pass it on!

www.path.ox.ac.uk/work-with-us...

Group Leader Career Development Fellowships - Dunn School

Are you an early career researcher interested in the cell or molecular mechanisms underlying disease? Do you have an outstanding record and an innovative research plan?

www.path.ox.ac.uk

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Andreas Prokop @poppi62.bsky.social · Aug 25

Dear GenZ members of the #Drosophila community! You are needed to make cool fly research viral in your social media world! As a boomer I do not understand that sphere, but I can consult and contribute our enormous fund of outreach resources: droso4public.wordpress.com. Please, get in contact!

(no title)

droso4public is a central resource store supporting science communication and advocacy for Drosophila

droso4public.wordpress.com

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Reposted by Simon Bullock

Elif Nur Firat-Karalar @cytolabkoc.bsky.social · Aug 26

New paper on DYRK kinases and primary cilium!
This project began with our interest in DYRK3’s relationship to centriolar satellites. But what started as a CS-focused story soon evolved into studying DYRK kinase activity during ciliogenesis.
nature.com/articles/s42...

Kinase activity of DYRK family members is required for regulating primary cilium length, stability and morphology - Communications Biology

DYRK3 kinase interacts with multiple centriolar satellites and ciliary components to regulate axoneme length dynamics in cooperation with DYRK2.

nature.com

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Reposted by Simon Bullock

Michael Way @drmichaelway.bsky.social · Aug 20

💥 Another Cryo-ET study from the Way lab by ‪@miguel-virus-cells.bsky.social‬ in collaboration with Rosenthal lab @crick.ac.uk‬ examining Vaccinia virus egress 😀👇 www.biorxiv.org/content/10.1...

In situ cryo-electron tomography of vaccinia virus exit from infected cells

Poxvirus-infected cells release newly assembled virions via Golgi-mediated envelopment and subsequent exocytosis at the plasma membrane, prior to cell lysis. Here, we used cryo-electron tomography and...

www.biorxiv.org

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Reposted by Simon Bullock

MRC Laboratory of Molecular Biology @mrclmb.bsky.social · Aug 20

We’re looking for a #postdoc to join Michael Hastings’ group, studying diet-induced neuroinflammation in the hypothalamus and its modulation by circadian clock mechanisms, in collaboration with John O'Neill's group.
www.nature.com/naturecareer...
Closes 08 SEP
#ScienceJobs #PostdocJobs

Michael Hastings in a light pink shirt stands with arms crossed in front of scientific research posters filled with charts and graphs.

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Reposted by Simon Bullock

Cahir O'Kane @cahirokane.bsky.social · Aug 6

A beautiful model of an mRNA transport complex that looks like a Texas congressional district

Carter Lab @carter-lab.bsky.social · Aug 5

Excited to share our latest work with @simonbullock11.bsky.social! We looked at how diverse mRNAs get selected for subcellular localization and it turns out that a single protein can recognize different RNA elements using shared features that weren’t apparent before.
www.biorxiv.org/content/10.1...

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Griffiths Lab @griffithslab.bsky.social · Aug 4

Sometimes, knocking out a gene isn't a good way to figure out the function of that gene ...

In our new @jcellsci.bsky.social paper, we report potent transcriptional adaptation by cytotoxic T lymphocytes (CTLs) in response to CRISPR/Cas9-mediated deletion of the important polarity protein CDC42 🧵⬇️

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Reposted by Simon Bullock

Carter Lab @carter-lab.bsky.social · Aug 5

Excited to share our latest work with @simonbullock11.bsky.social! We looked at how diverse mRNAs get selected for subcellular localization and it turns out that a single protein can recognize different RNA elements using shared features that weren’t apparent before.
www.biorxiv.org/content/10.1...

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Simon Bullock @simonbullock11.bsky.social · Aug 5

Our latest work, in collaboration with the terrific @kashishsingh.bsky.social in the Carter lab @mrclmb.bsky.social is out. So proud of this study and everyone involved...

bioRxiv Cell Biology @biorxiv-cellbio.bsky.social · Aug 2

Cryo-EM structures of Egl-BicD-RNA complexes reveal how diverse mRNAs are selected for subcellular localization https://www.biorxiv.org/content/10.1101/2025.08.02.668268v1

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Sjors Scheres @sjorsscheres.bsky.social · Aug 5

Fantastic work by the group of @matteoall.bsky.social : a SUN5:Nesprin3 complex at the head:tail junction of sperm cells. 🤯 #teamtomo

www.biorxiv.org/content/10.1...

In-cell structure of a LINC complex reveals the molecular basis for membrane remodelling and head-to-tail coupling in sperm cells

In eukaryotic cells, LINC complexes physically bridge the two nuclear membranes to cytoskeletal filaments, transmitting mechanical forces to the nucleus. Due to their dynamic and membrane-embedded nat...

www.biorxiv.org

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Reposted by Simon Bullock

Aixa V. Morales @aixa-v-morales.bsky.social · Aug 4

Our new work on the establishment of quiescence in #adultneurogenesis , done at @institutocajal.bsky.social @csic.es, is out in @plosbiology.org .
Proud of a Great team, Cristina Medina,
@paulatiradom.bsky.social , Lingling Li , @pilar-rguezm.bsky.social and the rest ! 🎊🎉🧠

PLOS Biology @plosbiology.org · Jul 31

Quiescent hippocampal #NeuralStemCells (NSCs) support #neurogenesis in adulthood. @aixa-v-morales.bsky.social &co show that NSCs have different levels of quiescence & that Sox5 controls the balance between shallow & deep quiescence during hippocampal development @plosbiology.org 🧪 plos.io/44Su34u

Top: DCX+ immature neurons (blue) in the hippocampal dentate gyrus of a conditional mutant mouse for Sox5, with recombined Sox5 deficient cells in magenta. Image credit: Cristina Medina-Menéndez. Bottom: Summary of NSC quiescence dynamics during early postnatal DG development (left) and their alterations in Sox5null mice (right).

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Reposted by Simon Bullock

Phil Holliger @philholliger.bsky.social · Jul 14

We are looking to recruit a tenure track group leader in the field of Chemical/Synthetic Biology (in the broadest sense) to lead a research program within the Division of Protein & Nucleic Acid Chemistry ( www.jobs.ac.uk/job/DNW809/r... ) at the MRC Laboratory of Molecular Biology (LMB).

Research Group Leader in Chemical/Synthetic Biology at MRC Laboratory of Molecular Biology

Start your UK & international job search for academic jobs, research jobs, science jobs and managerial jobs in leading universities and top...

www.jobs.ac.uk

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Reposted by Simon Bullock

Liz Miller @lizmillercu.bsky.social · Aug 4

Go check out the latest preprint from Giulia Zanetti's lab. @dr-downes.bsky.social used cryo-tomography to directly visualize COPI and COPII coated vesicles in situ at unprecedented resolution in human cells. Amazingly beautiful, rigorous, insightful work.
www.biorxiv.org/content/10.1...

Multi-scale Molecular Imaging of Human Cells reveals COPI and COPII Vesicles at ER Exit Sites

Trafficking from the endoplasmic reticulum to the Golgi apparatus comprises the first steps toward the correct localization of 30% of eukaryotic proteins. Coat protein complexes COPII and COPI are inv...

www.biorxiv.org

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