Anestis Tsakiridis
@tsakiridis.bsky.social
Research group leader and Senior Lecturer at the University of Sheffield. Stem cells, embryonic development, disease modelling, regenerative medicine: https://www.tsakiridislab.com/
Reposted by Anestis Tsakiridis
We are very happy to share our new PrePrint: Myosin VI orchestrates estrogen-driven gene expression in breast
cancer cells. www.biorxiv.org/content/10.1...
We characterise how Myosin VI is a key regulator of the Estrogen Receptor. Perturbation of Myosin VI impedes ER functionality.
cancer cells. www.biorxiv.org/content/10.1...
We characterise how Myosin VI is a key regulator of the Estrogen Receptor. Perturbation of Myosin VI impedes ER functionality.
November 14, 2025 at 9:33 AM
We are very happy to share our new PrePrint: Myosin VI orchestrates estrogen-driven gene expression in breast
cancer cells. www.biorxiv.org/content/10.1...
We characterise how Myosin VI is a key regulator of the Estrogen Receptor. Perturbation of Myosin VI impedes ER functionality.
cancer cells. www.biorxiv.org/content/10.1...
We characterise how Myosin VI is a key regulator of the Estrogen Receptor. Perturbation of Myosin VI impedes ER functionality.
Reposted by Anestis Tsakiridis
Join us in Sheffield! We are keen to support early career researchers in applying for independent research fellowships (IRFs) to join our friendly and collaborative environment, in areas related to developmental biology, stem cells and regenerative biology, and neuroscience.
November 12, 2025 at 10:16 AM
Join us in Sheffield! We are keen to support early career researchers in applying for independent research fellowships (IRFs) to join our friendly and collaborative environment, in areas related to developmental biology, stem cells and regenerative biology, and neuroscience.
Reposted by Anestis Tsakiridis
Today’s speaker in our DRN external seminar series is Professor Jens Januschke (University of Dundee) @dundee.ac.uk
Host: Kyra Campbell
@kyracampbelllab.bsky.social
All welcome!
Host: Kyra Campbell
@kyracampbelllab.bsky.social
All welcome!
November 12, 2025 at 9:55 AM
Today’s speaker in our DRN external seminar series is Professor Jens Januschke (University of Dundee) @dundee.ac.uk
Host: Kyra Campbell
@kyracampbelllab.bsky.social
All welcome!
Host: Kyra Campbell
@kyracampbelllab.bsky.social
All welcome!
Reposted by Anestis Tsakiridis
📣 Paper alert!
I am delighted that our paper exploring the impact of Neanderthal-derived variants on the activity of a disease-associated craniofacial enhancer has been published in Development today!
journals.biologists.com/dev/article/...
I am delighted that our paper exploring the impact of Neanderthal-derived variants on the activity of a disease-associated craniofacial enhancer has been published in Development today!
journals.biologists.com/dev/article/...
November 10, 2025 at 11:11 AM
📣 Paper alert!
I am delighted that our paper exploring the impact of Neanderthal-derived variants on the activity of a disease-associated craniofacial enhancer has been published in Development today!
journals.biologists.com/dev/article/...
I am delighted that our paper exploring the impact of Neanderthal-derived variants on the activity of a disease-associated craniofacial enhancer has been published in Development today!
journals.biologists.com/dev/article/...
Reposted by Anestis Tsakiridis
An exciting PhD opportunity to work at the University of Sheffield on how e-cigarettes affect reproduction and offspring: www.findaphd.com/phds/project...
BBSRC Yorkshire Bioscience DLA Programme: Defining the Reproductive and Offspring Developmental Impacts of e-Cigarettes at University of Sheffield on FindAPhD.com
PhD Project - BBSRC Yorkshire Bioscience DLA Programme: Defining the Reproductive and Offspring Developmental Impacts of e-Cigarettes at University of Sheffield, listed on FindAPhD.com
www.findaphd.com
November 6, 2025 at 2:30 PM
An exciting PhD opportunity to work at the University of Sheffield on how e-cigarettes affect reproduction and offspring: www.findaphd.com/phds/project...
Reposted by Anestis Tsakiridis
Please repost - Multiple PhDs available
www.findaphd.com/phds/project...
www.findaphd.com/phds/project...
www.findaphd.com/phds/project...
www.findaphd.com/phds/project...
www.findaphd.com/phds/project...
www.findaphd.com/phds/project...
November 5, 2025 at 9:18 AM
Please repost - Multiple PhDs available
www.findaphd.com/phds/project...
www.findaphd.com/phds/project...
www.findaphd.com/phds/project...
www.findaphd.com/phds/project...
www.findaphd.com/phds/project...
www.findaphd.com/phds/project...
Reposted by Anestis Tsakiridis
🚨 Come join us @sheffielduni.bsky.social for a PhD on the evolution and development of feathers and flight! 🐣🔬
This project is supervised by @matt-towers.bsky.social & @alexgfletcher.bsky.social, and I'm excited to be involved as a project advisor. Please share!
www.findaphd.com/phds/project... 🧪
This project is supervised by @matt-towers.bsky.social & @alexgfletcher.bsky.social, and I'm excited to be involved as a project advisor. Please share!
www.findaphd.com/phds/project... 🧪
November 3, 2025 at 2:46 PM
🚨 Come join us @sheffielduni.bsky.social for a PhD on the evolution and development of feathers and flight! 🐣🔬
This project is supervised by @matt-towers.bsky.social & @alexgfletcher.bsky.social, and I'm excited to be involved as a project advisor. Please share!
www.findaphd.com/phds/project... 🧪
This project is supervised by @matt-towers.bsky.social & @alexgfletcher.bsky.social, and I'm excited to be involved as a project advisor. Please share!
www.findaphd.com/phds/project... 🧪
Reposted by Anestis Tsakiridis
Last chance to apply - closing Nov 3rd: www.jobs.cam.ac.uk/job/52936/ Consider coming to Cambridge to work on a highly collaborative project on lung stem cells and lung disease with @labrawlins.bsky.social and @jennydickens41.bsky.social
October 31, 2025 at 4:29 PM
Last chance to apply - closing Nov 3rd: www.jobs.cam.ac.uk/job/52936/ Consider coming to Cambridge to work on a highly collaborative project on lung stem cells and lung disease with @labrawlins.bsky.social and @jennydickens41.bsky.social
Reposted by Anestis Tsakiridis
🚨 PhD Projects 🚨
We are advertising two UKRI funded PhD projects at the @sheffielduni.bsky.social. #stemcells #development #embryology #reproductivephysiology #mathmaticalmodelling #quantitativebiology
We are advertising two UKRI funded PhD projects at the @sheffielduni.bsky.social. #stemcells #development #embryology #reproductivephysiology #mathmaticalmodelling #quantitativebiology
October 31, 2025 at 7:39 AM
🚨 PhD Projects 🚨
We are advertising two UKRI funded PhD projects at the @sheffielduni.bsky.social. #stemcells #development #embryology #reproductivephysiology #mathmaticalmodelling #quantitativebiology
We are advertising two UKRI funded PhD projects at the @sheffielduni.bsky.social. #stemcells #development #embryology #reproductivephysiology #mathmaticalmodelling #quantitativebiology
Reposted by Anestis Tsakiridis
Thrilled to share my main postdoc work with @jamesbriscoe.bsky.social
We used genomic barcoding + scRNAseq in chick & human embryos to reveal a lineage architecture that reshapes how we understand neural tube development & cell fate decisions
🧵👇
www.biorxiv.org/content/10.1...
We used genomic barcoding + scRNAseq in chick & human embryos to reveal a lineage architecture that reshapes how we understand neural tube development & cell fate decisions
🧵👇
www.biorxiv.org/content/10.1...
Hierarchical lineage architecture of human and avian spinal cord revealed by single-cell genomic barcoding
The formation of neural circuits depends on the precise spatial and temporal organisation of neuronal populations during development. In the vertebrate spinal cord, progenitors are patterned into mole...
www.biorxiv.org
October 26, 2025 at 5:15 PM
Thrilled to share my main postdoc work with @jamesbriscoe.bsky.social
We used genomic barcoding + scRNAseq in chick & human embryos to reveal a lineage architecture that reshapes how we understand neural tube development & cell fate decisions
🧵👇
www.biorxiv.org/content/10.1...
We used genomic barcoding + scRNAseq in chick & human embryos to reveal a lineage architecture that reshapes how we understand neural tube development & cell fate decisions
🧵👇
www.biorxiv.org/content/10.1...
Reposted by Anestis Tsakiridis
I am absolutely delighted to share the invited speakers for our upcoming @bsdb.bsky.social "Molecules to Morphogenesis" meeting!
Registration and abstract submission is now open - join us!
bsdb.org/meetings/
March 23-26, 2026 - UK
Registration and abstract submission is now open - join us!
bsdb.org/meetings/
March 23-26, 2026 - UK
October 23, 2025 at 5:25 PM
I am absolutely delighted to share the invited speakers for our upcoming @bsdb.bsky.social "Molecules to Morphogenesis" meeting!
Registration and abstract submission is now open - join us!
bsdb.org/meetings/
March 23-26, 2026 - UK
Registration and abstract submission is now open - join us!
bsdb.org/meetings/
March 23-26, 2026 - UK
Reposted by Anestis Tsakiridis
Hot on the heels of our recent basic science preprint. Check out our preprint of a data driven study looking at Hirschsprung Disease Outcomes of children in England using ECHILD (medrxiv.org/cgi/content/...).
Childhood outcomes in children with Hirschsprung disease: a population-based data linkage study in England
Objective Hirschsprung disease (HSCR) is a rare congenital intestinal condition that, despite lifesaving surgery, can result in increased hospitalisations and a lower quality of life throughout childh...
medrxiv.org
October 20, 2025 at 10:28 AM
Hot on the heels of our recent basic science preprint. Check out our preprint of a data driven study looking at Hirschsprung Disease Outcomes of children in England using ECHILD (medrxiv.org/cgi/content/...).
Reposted by Anestis Tsakiridis
Check out our lab’s new preprint (www.biorxiv.org/content/10.1...) on the consequences of ENS progenitor transplantation to mouse Hirschsprung disease explants. Delighted to continue a fruitful collaboration with
@tsakiridis.bsky.social
to develop a #celltherapy for #Hirschsprungs
@tsakiridis.bsky.social
to develop a #celltherapy for #Hirschsprungs
Functional and molecular rescue of aganglionic colon by human enteric nervous system progenitor transplantation in Hirschsprung disease
Hirschsprung disease (HSCR) is a devastating congenital disorder characterised by absence of the enteric nervous system (ENS) in the distal gut. Cell therapy, using human pluripotent stem cell-derived...
www.biorxiv.org
October 17, 2025 at 11:08 AM
Check out our lab’s new preprint (www.biorxiv.org/content/10.1...) on the consequences of ENS progenitor transplantation to mouse Hirschsprung disease explants. Delighted to continue a fruitful collaboration with
@tsakiridis.bsky.social
to develop a #celltherapy for #Hirschsprungs
@tsakiridis.bsky.social
to develop a #celltherapy for #Hirschsprungs
Reposted by Anestis Tsakiridis
Happy to share our new preprint!
Simplified In Vitro Generation of Human Gastruloids for Modelling Early Development https://www.biorxiv.org/content/10.1101/2025.10.15.682610v1
October 16, 2025 at 4:53 AM
Happy to share our new preprint!
Reposted by Anestis Tsakiridis
Today we are honoured to host Dr Sally Lowell @cellysally.bsky.social (University of Edinburgh), winner of the 2024 BSDB Wolpert Medal, who is giving a talk in our DRN external seminar series
@bsdb.bsky.social
Host: Marysia Placzek
All welcome!
@bsdb.bsky.social
Host: Marysia Placzek
All welcome!
October 15, 2025 at 7:39 AM
Today we are honoured to host Dr Sally Lowell @cellysally.bsky.social (University of Edinburgh), winner of the 2024 BSDB Wolpert Medal, who is giving a talk in our DRN external seminar series
@bsdb.bsky.social
Host: Marysia Placzek
All welcome!
@bsdb.bsky.social
Host: Marysia Placzek
All welcome!
I am co-organising a @cclguk.bsky.social @dmmjournal.bsky.social symposium on the developmental origins of paediatric cancers at the @crick.ac.uk on 8/6/2026. Great speaker line up, affordable registration and available slots for short talks-spread the word! www.cclg.org.uk/information-...
Developmental origins of paediatric cancer symposium
A one-day event showcasing the latest cutting-edge research on the modelling, biology and treatment of paediatric cancers in the context of their developmental origins.
www.cclg.org.uk
October 6, 2025 at 4:05 PM
I am co-organising a @cclguk.bsky.social @dmmjournal.bsky.social symposium on the developmental origins of paediatric cancers at the @crick.ac.uk on 8/6/2026. Great speaker line up, affordable registration and available slots for short talks-spread the word! www.cclg.org.uk/information-...
Reposted by Anestis Tsakiridis
Many enhancers that drive tissue-specific gene expression are already connected to gene promoters in human pluripotent cells.
In a new preprint, we share some clues about when, how, and why this happens!
www.biorxiv.org/content/10.1...
In a new preprint, we share some clues about when, how, and why this happens!
www.biorxiv.org/content/10.1...
Poising and connectivity of emergent human developmental enhancers in the transition from naive to primed pluripotency
In primed human pluripotent stem cells (hPSCs) resembling post-implantation epiblast, numerous lineage-specific enhancers assume the poised chromatin state, co-marked by H3K4me1 and Polycomb-associate...
www.biorxiv.org
October 3, 2025 at 3:09 PM
Many enhancers that drive tissue-specific gene expression are already connected to gene promoters in human pluripotent cells.
In a new preprint, we share some clues about when, how, and why this happens!
www.biorxiv.org/content/10.1...
In a new preprint, we share some clues about when, how, and why this happens!
www.biorxiv.org/content/10.1...
Reposted by Anestis Tsakiridis
How do #stemcells integrate information to coordinate fate decisions? Delighted to finally see our work showing how growth factors regulate the mechano-osmotic state of the #nucleus and #chromatin to control #pluripotency exit out! www.nature.com/articles/s41... see 🧵 👇
Mechano-osmotic signals control chromatin state and fate transitions in pluripotent stem cells - Nature Cell Biology
McCreery, Stubb et al. show that mechano-osmotic changes in the nucleus induce general transcriptional repression and prime chromatin for cell fate transitions by relieving repression of specific differentiation genes.
www.nature.com
September 29, 2025 at 4:45 PM
How do #stemcells integrate information to coordinate fate decisions? Delighted to finally see our work showing how growth factors regulate the mechano-osmotic state of the #nucleus and #chromatin to control #pluripotency exit out! www.nature.com/articles/s41... see 🧵 👇
Reposted by Anestis Tsakiridis
Neuroblastoma-associated ALK variants have distinct cellular and biochemical activities https://www.biorxiv.org/content/10.1101/2025.09.25.677354v1
September 26, 2025 at 5:46 AM
Neuroblastoma-associated ALK variants have distinct cellular and biochemical activities https://www.biorxiv.org/content/10.1101/2025.09.25.677354v1
Reposted by Anestis Tsakiridis
@mariasecrier.bsky.social & I are looking for an enthusiastic & excellent data scientist for a 4-year postdoc to understand cell cycle dysregulation in cancer.
Deadline 15th October. Get in touch if you have any questions.
Please repost!
More details:
www.imperial.ac.uk/jobs/search-...
Deadline 15th October. Get in touch if you have any questions.
Please repost!
More details:
www.imperial.ac.uk/jobs/search-...
Description
Please note that job descriptions are not exhaustive, and you may be asked to take on additional duties that align with the key responsibilities ment...
www.imperial.ac.uk
September 18, 2025 at 8:02 PM
@mariasecrier.bsky.social & I are looking for an enthusiastic & excellent data scientist for a 4-year postdoc to understand cell cycle dysregulation in cancer.
Deadline 15th October. Get in touch if you have any questions.
Please repost!
More details:
www.imperial.ac.uk/jobs/search-...
Deadline 15th October. Get in touch if you have any questions.
Please repost!
More details:
www.imperial.ac.uk/jobs/search-...
Reposted by Anestis Tsakiridis
We have an exciting, fully funded PhD studentship (UK and ROI) to investigate mechanisms of epigenetic regulation in drug resistant B-cell lymphoma.
We are looking for a highly motivated, driven candidate to join our team.
eur02.safelinks.protection.outlook.com?url=https%3A...
We are looking for a highly motivated, driven candidate to join our team.
eur02.safelinks.protection.outlook.com?url=https%3A...
Targeting USP7-PRC1 axis as a novel therapeutic approach in drug resistant Diffuse Large B-Cell Lymphoma at Queen’s University Belfast on FindAPhD.com
PhD Project - Targeting USP7-PRC1 axis as a novel therapeutic approach in drug resistant Diffuse Large B-Cell Lymphoma at Queen’s University Belfast, listed on FindAPhD.com
eur02.safelinks.protection.outlook.com
September 18, 2025 at 3:36 AM
We have an exciting, fully funded PhD studentship (UK and ROI) to investigate mechanisms of epigenetic regulation in drug resistant B-cell lymphoma.
We are looking for a highly motivated, driven candidate to join our team.
eur02.safelinks.protection.outlook.com?url=https%3A...
We are looking for a highly motivated, driven candidate to join our team.
eur02.safelinks.protection.outlook.com?url=https%3A...
Reposted by Anestis Tsakiridis
I am advertising for a #postdoc for a 3 year BBSRC-funded project exploring the role of macrophages in salivary gland development. The successful candidate will be based at @edinuni-irr.bsky.social at @uni-of-edinburgh.bsky.social. Closing date: 9th Oct. elxw.fa.em3.oraclecloud.com/hcmUI/Candid...
Postdoctoral Research Fellow
An exciting opportunity has arisen to join the Emmerson lab within the Institute for Regeneration and Repair at the University of Edinburgh. This three year, BBSRC-funded postdoctoral research associa...
elxw.fa.em3.oraclecloud.com
September 13, 2025 at 8:58 AM
I am advertising for a #postdoc for a 3 year BBSRC-funded project exploring the role of macrophages in salivary gland development. The successful candidate will be based at @edinuni-irr.bsky.social at @uni-of-edinburgh.bsky.social. Closing date: 9th Oct. elxw.fa.em3.oraclecloud.com/hcmUI/Candid...
A 6-month postdoc position is currently available in our group. The project involves the use of hPSC-based models to dissect the links between chromosomal copy number alterations, DNA damage and tumour initiation-please spread the word-closing date=29th Sept: www.jobs.ac.uk/job/DON353/r...
Research Associate (Stem Cell/Cancer Biology)
Research Associate (Stem Cell/Cancer Biology)
jobsite.sheffield.ac.uk
September 11, 2025 at 10:32 AM
A 6-month postdoc position is currently available in our group. The project involves the use of hPSC-based models to dissect the links between chromosomal copy number alterations, DNA damage and tumour initiation-please spread the word-closing date=29th Sept: www.jobs.ac.uk/job/DON353/r...
Reposted by Anestis Tsakiridis
I'm a bit late to the party over here. I'll be advertising a BBSRC-funded postdoc position soon. So if anyone wants to solve some outstanding questions in limb development - please get in touch. We have a variety of models and approaches (everything from stem cells to sharks). towerslab.weebly.com
September 9, 2025 at 5:58 PM
I'm a bit late to the party over here. I'll be advertising a BBSRC-funded postdoc position soon. So if anyone wants to solve some outstanding questions in limb development - please get in touch. We have a variety of models and approaches (everything from stem cells to sharks). towerslab.weebly.com