Elaine Emmerson
@doctoremmerson.bsky.social
PI of @emmersonlab-irr.bsky.social at @edinuni-irr.bsky.social studying regeneration after cancer radiotherapy | Academic Lead for Public Engagement | Stepmum, vegetarian, baker, cyclist
A common LGR5+ cell gives rise to the #tongue epithelium, the #tastebuds and the von Ebner #salivaryglands. A lovely study from @hansclevers.bsky.social and colleagues.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Tripotent Lgr5 stem cells in the posterior tongue generate lingual, taste, and salivary gland lineages - Nature Communications
Here, the authors show that a single Lgr5 stem cell population in the posterior tongue produces taste buds, salivary glands, and epithelium, representing unified chemosensory units.
www.nature.com
November 24, 2025 at 9:13 AM
A common LGR5+ cell gives rise to the #tongue epithelium, the #tastebuds and the von Ebner #salivaryglands. A lovely study from @hansclevers.bsky.social and colleagues.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Elaine Emmerson
If you work with #scRNAseq, #salivary, #thyroid or #mammary gland #organoids, or are interested in #irradiation and #Notch signaling, you might find this exciting! Our latest paper is now available in @embojournal.org! Check it out! Link below ✨
doi.org/10.1038/s443...
doi.org/10.1038/s443...
November 11, 2025 at 1:15 AM
If you work with #scRNAseq, #salivary, #thyroid or #mammary gland #organoids, or are interested in #irradiation and #Notch signaling, you might find this exciting! Our latest paper is now available in @embojournal.org! Check it out! Link below ✨
doi.org/10.1038/s443...
doi.org/10.1038/s443...
Reposted by Elaine Emmerson
Extremely excited to see this out in @science.org Signaling! In this study, we explored the molecular differences between #photon and #proton irradiation and uncovered how #salivary gland stem cells respond to the resulting #inflammatory cues.
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
IFN-I signaling enhances salivary gland stem and progenitor cell activity after irradiation
Regenerative responses in salivary gland organoids after irradiation are mediated by IFN-I signaling.
www.science.org
November 20, 2025 at 5:34 PM
Extremely excited to see this out in @science.org Signaling! In this study, we explored the molecular differences between #photon and #proton irradiation and uncovered how #salivary gland stem cells respond to the resulting #inflammatory cues.
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Reposted by Elaine Emmerson
Delighted to share this! We identify gut #macrophages as key players in preventing dissemination of intestinal microbes in liver cirrhosis. Best collab with my partner in crime @lenasmets.bsky.social, featuring some stunning live imaging with @colindascheele.bsky.social
👇
gut.bmj.com/content/earl...
👇
gut.bmj.com/content/earl...
Intestinal blood vessel-associated macrophages and gut-vascular barrier dysfunction in cirrhosis
Background Bacterial translocation in cirrhosis can trigger infection and hepatic decompensation, leading to systemic inflammation, organ failure and increased mortality. These infections often origin...
gut.bmj.com
November 19, 2025 at 9:42 PM
Delighted to share this! We identify gut #macrophages as key players in preventing dissemination of intestinal microbes in liver cirrhosis. Best collab with my partner in crime @lenasmets.bsky.social, featuring some stunning live imaging with @colindascheele.bsky.social
👇
gut.bmj.com/content/earl...
👇
gut.bmj.com/content/earl...
Thrilled for our wonderful postdoc @lizihegarty.bsky.social whose #PhD work on colonic #macrophages and #colitis with @bainlab.bsky.social @edinuni-irr.bsky.social has been accepted for publication in @mucosalimmunol.bsky.social 🔬
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Tissue resident colonic macrophages persist through acute inflammation and adapt to aid tissue repair
Macrophages are crucial for the maintenance of intestinal homeostasis, are considered key proinflammatory effector cells during intestinal inflammatio…
www.sciencedirect.com
November 19, 2025 at 5:09 PM
Thrilled for our wonderful postdoc @lizihegarty.bsky.social whose #PhD work on colonic #macrophages and #colitis with @bainlab.bsky.social @edinuni-irr.bsky.social has been accepted for publication in @mucosalimmunol.bsky.social 🔬
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
A beautiful study describing cell fate acquisition in bilayered #epithelia, inc. my fave #salivarygland, published in @cp-devcell.bsky.social
Conserved signals control self-organization & symmetry breaking of murine bilayered epithelia during development & regeneration
www.cell.com/developmenta...
Conserved signals control self-organization & symmetry breaking of murine bilayered epithelia during development & regeneration
www.cell.com/developmenta...
Conserved signals control self-organization and symmetry breaking of murine bilayered epithelia during development and regeneration
Journot et al. explore fate specification during embryonic development and regeneration
of bilayered glandular epithelia. They uncover conserved molecular mechanisms linking
tissue architecture with c...
www.cell.com
October 26, 2025 at 10:57 AM
A beautiful study describing cell fate acquisition in bilayered #epithelia, inc. my fave #salivarygland, published in @cp-devcell.bsky.social
Conserved signals control self-organization & symmetry breaking of murine bilayered epithelia during development & regeneration
www.cell.com/developmenta...
Conserved signals control self-organization & symmetry breaking of murine bilayered epithelia during development & regeneration
www.cell.com/developmenta...
Wonderful to see this lovely data out in @mucosalimmunol.bsky.social! Congratulations to @nabinapun.bsky.social, @douglaspdyer.bsky.social & colleagues of @lydiabeckeriii.bsky.social & @mcrcellmatrix.bsky.social! 👏
#monocyte #radiotherapy #intestinal #toxicity
www.sciencedirect.com/science/arti...
#monocyte #radiotherapy #intestinal #toxicity
www.sciencedirect.com/science/arti...
CCR2-driven monocyte recruitment is protective against radiotherapy-induced intestinal toxicity
Radiotherapy (RT) is essential in treating abdominal and pelvic cancers but often damages the healthy tissues, particularly the intestines, leading to…
www.sciencedirect.com
October 26, 2025 at 10:50 AM
Wonderful to see this lovely data out in @mucosalimmunol.bsky.social! Congratulations to @nabinapun.bsky.social, @douglaspdyer.bsky.social & colleagues of @lydiabeckeriii.bsky.social & @mcrcellmatrix.bsky.social! 👏
#monocyte #radiotherapy #intestinal #toxicity
www.sciencedirect.com/science/arti...
#monocyte #radiotherapy #intestinal #toxicity
www.sciencedirect.com/science/arti...
📖 A very comprehensive review of the heterogeneity, crosstalk and therapeutic potential of #salivarygland #macrophages including reference to several papers from @emmersonlab-irr.bsky.social
📚 #immunosky
www.frontiersin.org/journals/imm...
📚 #immunosky
www.frontiersin.org/journals/imm...
Frontiers | Salivary gland macrophages in health and disease: heterogeneity, niche crosstalk, and therapeutic avenues
Salivary glands (SGs) produce saliva essential for digestion, mucosal immunity, and as a source of non-invasive biomarkers. The health and pathology of SGs h...
www.frontiersin.org
October 19, 2025 at 3:36 PM
📖 A very comprehensive review of the heterogeneity, crosstalk and therapeutic potential of #salivarygland #macrophages including reference to several papers from @emmersonlab-irr.bsky.social
📚 #immunosky
www.frontiersin.org/journals/imm...
📚 #immunosky
www.frontiersin.org/journals/imm...
TGFb mediates #macrophage specialisation and crosstalk with sensory #nerves in the #skin after injury. A beautiful study by Julia Kolter, Philipp Henneke and colleagues published in @cp-immunity.bsky.social #immunosky
www.cell.com/immunity/ful...
www.cell.com/immunity/ful...
Sensory neurons shape local macrophage identity via TGF-β signaling
Specialized macrophages are known to persist within tissue niches, but the molecular
mechanisms guiding their sustained functional adaptation remain unclear. Kolter and
Döring et al. show that local i...
www.cell.com
October 16, 2025 at 9:00 AM
TGFb mediates #macrophage specialisation and crosstalk with sensory #nerves in the #skin after injury. A beautiful study by Julia Kolter, Philipp Henneke and colleagues published in @cp-immunity.bsky.social #immunosky
www.cell.com/immunity/ful...
www.cell.com/immunity/ful...
Reposted by Elaine Emmerson
“For Gurdon to continue in biology would be a complete waste of time both for him and for those who would have to teach him”
He proved them wrong! RIP John Gurdon
www.cell.com/current-biol...
He proved them wrong! RIP John Gurdon
www.cell.com/current-biol...
John Gurdon
John Gurdon is at the Wellcome Trust/Cancer Research UK Institute of Cancer and Developmental
Biology in Cambridge. Educated at Eton and Christ Church, Oxford, he changed from
classics to zoology. Dur...
www.cell.com
October 7, 2025 at 4:21 PM
“For Gurdon to continue in biology would be a complete waste of time both for him and for those who would have to teach him”
He proved them wrong! RIP John Gurdon
www.cell.com/current-biol...
He proved them wrong! RIP John Gurdon
www.cell.com/current-biol...
Great to see this out for all to see after a lot of hard work by @lizihegarty.bsky.social and @bainlab.bsky.social. Colonic #macrophages persist but are transcriptionally altered post- #inflammation in a mouse model of #colitis.
Tissue resident colonic macrophages persist through acute inflammation and adapt to aid tissue repair https://www.biorxiv.org/content/10.1101/2025.09.19.677333v1
September 22, 2025 at 6:48 AM
Great to see this out for all to see after a lot of hard work by @lizihegarty.bsky.social and @bainlab.bsky.social. Colonic #macrophages persist but are transcriptionally altered post- #inflammation in a mouse model of #colitis.
Absolutely delighted that our superstar #postdoc @lizihegarty.bsky.social was awarded the @cmvm-edinburghuni.bsky.social Student Support & Supervision Award for #PAW 2025. Thoroughly deserved for everything she does for @emmersonlab-irr.bsky.social, @bainlab.bsky.social & @edinuni-irr.bsky.social
September 19, 2025 at 5:57 PM
Absolutely delighted that our superstar #postdoc @lizihegarty.bsky.social was awarded the @cmvm-edinburghuni.bsky.social Student Support & Supervision Award for #PAW 2025. Thoroughly deserved for everything she does for @emmersonlab-irr.bsky.social, @bainlab.bsky.social & @edinuni-irr.bsky.social
A cracking meal complete with piper & Ceilidh to round off the second day of #EMDS2025 in #Edinburgh
September 17, 2025 at 11:37 PM
A cracking meal complete with piper & Ceilidh to round off the second day of #EMDS2025 in #Edinburgh
#EMDS2025 attendees - if anyone is looking for a postdoc position and likes what they see of #Edinburgh, please come and speak to me or @lizihegarty.bsky.social (poster 71) or @erinwatson.bsky.social (poster 35).
I am advertising for a #postdoc for a 3 year BBSRC-funded project exploring the role of macrophages in salivary gland development. The successful candidate will be based at @edinuni-irr.bsky.social at @uni-of-edinburgh.bsky.social. Closing date: 9th Oct. elxw.fa.em3.oraclecloud.com/hcmUI/Candid...
Postdoctoral Research Fellow
An exciting opportunity has arisen to join the Emmerson lab within the Institute for Regeneration and Repair at the University of Edinburgh. This three year, BBSRC-funded postdoctoral research associa...
elxw.fa.em3.oraclecloud.com
September 16, 2025 at 4:15 PM
#EMDS2025 attendees - if anyone is looking for a postdoc position and likes what they see of #Edinburgh, please come and speak to me or @lizihegarty.bsky.social (poster 71) or @erinwatson.bsky.social (poster 35).
Reposted by Elaine Emmerson
After a year of planning, we are ready.
Registration opens at 8am. Excited for 2.5days of great science and a bit of fun.
See you soon
Registration opens at 8am. Excited for 2.5days of great science and a bit of fun.
See you soon
September 16, 2025 at 6:39 AM
After a year of planning, we are ready.
Registration opens at 8am. Excited for 2.5days of great science and a bit of fun.
See you soon
Registration opens at 8am. Excited for 2.5days of great science and a bit of fun.
See you soon
For anyone wanting to know more about this #postdoc position, I’ll be at @emds2025.bsky.social this week. Alternatively, you’ll find @emmersonlab-irr.bsky.social members @lizihegarty.bsky.social & @erinwatson.bsky.social at posters 71 & 35 #academicjobs
I am advertising for a #postdoc for a 3 year BBSRC-funded project exploring the role of macrophages in salivary gland development. The successful candidate will be based at @edinuni-irr.bsky.social at @uni-of-edinburgh.bsky.social. Closing date: 9th Oct. elxw.fa.em3.oraclecloud.com/hcmUI/Candid...
Postdoctoral Research Fellow
An exciting opportunity has arisen to join the Emmerson lab within the Institute for Regeneration and Repair at the University of Edinburgh. This three year, BBSRC-funded postdoctoral research associa...
elxw.fa.em3.oraclecloud.com
September 15, 2025 at 8:13 AM
For anyone wanting to know more about this #postdoc position, I’ll be at @emds2025.bsky.social this week. Alternatively, you’ll find @emmersonlab-irr.bsky.social members @lizihegarty.bsky.social & @erinwatson.bsky.social at posters 71 & 35 #academicjobs
I am advertising for a #postdoc for a 3 year BBSRC-funded project exploring the role of macrophages in salivary gland development. The successful candidate will be based at @edinuni-irr.bsky.social at @uni-of-edinburgh.bsky.social. Closing date: 9th Oct. elxw.fa.em3.oraclecloud.com/hcmUI/Candid...
Postdoctoral Research Fellow
An exciting opportunity has arisen to join the Emmerson lab within the Institute for Regeneration and Repair at the University of Edinburgh. This three year, BBSRC-funded postdoctoral research associa...
elxw.fa.em3.oraclecloud.com
September 13, 2025 at 8:58 AM
I am advertising for a #postdoc for a 3 year BBSRC-funded project exploring the role of macrophages in salivary gland development. The successful candidate will be based at @edinuni-irr.bsky.social at @uni-of-edinburgh.bsky.social. Closing date: 9th Oct. elxw.fa.em3.oraclecloud.com/hcmUI/Candid...
Official advert coming soon! #postdoc #macrophages @britsocimm.bsky.social @emds2025.bsky.social
@edinuni-irr.bsky.social
@edinuni-irr.bsky.social
I'll soon be advertising for a 3 year postdoc to join our lab at @edinuni-irr.bsky.social exploring #macrophages in salivary gland #development. Candidates should have a strong background in immunology/macrophage biology and/or developmental biology & key skills as below. Informal enquiries welcome!
September 10, 2025 at 7:37 AM
Official advert coming soon! #postdoc #macrophages @britsocimm.bsky.social @emds2025.bsky.social
@edinuni-irr.bsky.social
@edinuni-irr.bsky.social
Lovely @emmersonlab-irr.bsky.social outing with @lizihegarty.bsky.social and & @erinwatson.bsky.social to celebrate @abelsoto.bsky.social joining the lab for the summer and welcome incoming PhD student Natalie
July 29, 2025 at 6:45 PM
Lovely @emmersonlab-irr.bsky.social outing with @lizihegarty.bsky.social and & @erinwatson.bsky.social to celebrate @abelsoto.bsky.social joining the lab for the summer and welcome incoming PhD student Natalie
I'll soon be advertising for a 3 year postdoc to join our lab at @edinuni-irr.bsky.social exploring #macrophages in salivary gland #development. Candidates should have a strong background in immunology/macrophage biology and/or developmental biology & key skills as below. Informal enquiries welcome!
July 26, 2025 at 12:17 PM
I'll soon be advertising for a 3 year postdoc to join our lab at @edinuni-irr.bsky.social exploring #macrophages in salivary gland #development. Candidates should have a strong background in immunology/macrophage biology and/or developmental biology & key skills as below. Informal enquiries welcome!
I am extremely honoured to say that I have been named as the @iadr.bsky.social Salivary Researcher of the Year 2025 🏆 This is testament to my incredible team & wonderful collaborators over the last 8 yrs & my superb postdoc training at @ucsanfrancisco.bsky.social #salivarygland #salivary #research
July 9, 2025 at 6:07 AM
I am extremely honoured to say that I have been named as the @iadr.bsky.social Salivary Researcher of the Year 2025 🏆 This is testament to my incredible team & wonderful collaborators over the last 8 yrs & my superb postdoc training at @ucsanfrancisco.bsky.social #salivarygland #salivary #research
As a postdoc I found that mimicking #nerve signals could help cell replenishment in #salivarygland. When I joined @edinuni-irr.bsky.social we teamed up with the incredible Unciti-Broceta lab from @uoe-igc.bsky.social to explore a novel #drugdelivery system: 📖 ➡️ www.researchsquare.com/article/rs-6...
Biodialyzed Palladium catalysis enables bioorthogonal drug release to control epithelial progenitor cell differentiation
Flowing from the principles of bioorthogonality, the introduction of abiotic transition metals for the catalytic production of drugs at specific anatomical locations has carved new paths to face chall...
www.researchsquare.com
July 3, 2025 at 8:48 AM
As a postdoc I found that mimicking #nerve signals could help cell replenishment in #salivarygland. When I joined @edinuni-irr.bsky.social we teamed up with the incredible Unciti-Broceta lab from @uoe-igc.bsky.social to explore a novel #drugdelivery system: 📖 ➡️ www.researchsquare.com/article/rs-6...
A beautiful study out now in @cp-devcell.bsky.social showing that tissue architecture drives cell fate in branched #epithelial organs during #development.
🧵Just out !
We reveal how 4 branched epithelia—mammary, lacrimal, salivary & prostate—use a conserved YAP–Notch–p63 circuit to self-organize during development & regeneration.
Here’s the story👇
authors.elsevier.com/c/1lM285Sx5g...
Work done in @frelab.bsky.social at
@institutcurie.bsky.social
We reveal how 4 branched epithelia—mammary, lacrimal, salivary & prostate—use a conserved YAP–Notch–p63 circuit to self-organize during development & regeneration.
Here’s the story👇
authors.elsevier.com/c/1lM285Sx5g...
Work done in @frelab.bsky.social at
@institutcurie.bsky.social
July 2, 2025 at 7:25 AM
A beautiful study out now in @cp-devcell.bsky.social showing that tissue architecture drives cell fate in branched #epithelial organs during #development.
Well done to @erinwatson.bsky.social for writing this wonderful review of what is known about macrophage crosstalk with peripheral nerves in a whole range of different tissues! @edinuni-irr.bsky.social #macrophage #nerve #neuroimmunology #immunosky
Delighted that our review paper covering all things nerve-macrophage in peripheral tissues has just been released! @doctoremmerson.bsky.social www.sciencedirect.com/science/arti...
Neuroimmunology beyond the CNS: Nerve-macrophage interactions in peripheral tissues
Macrophages are now recognised to be highly heterogeneous, with diverse ontogenies, anatomical locations and characteristics, all of which inform thei…
www.sciencedirect.com
June 26, 2025 at 5:03 PM
Well done to @erinwatson.bsky.social for writing this wonderful review of what is known about macrophage crosstalk with peripheral nerves in a whole range of different tissues! @edinuni-irr.bsky.social #macrophage #nerve #neuroimmunology #immunosky