Chris Toseland
@christoseland.bsky.social
Prof. Cancer Biophysics at University of Sheffield.
Investigating Nuclear Myosin, Nuclear Organisation and Mechanobiology in Cancer with single molecule Biophysics
Web: Toseland-lab.com
Investigating Nuclear Myosin, Nuclear Organisation and Mechanobiology in Cancer with single molecule Biophysics
Web: Toseland-lab.com
Pinned
Please repost - Multiple PhDs available
www.findaphd.com/phds/project...
www.findaphd.com/phds/project...
www.findaphd.com/phds/project...
www.findaphd.com/phds/project...
www.findaphd.com/phds/project...
www.findaphd.com/phds/project...
Reposted by Chris Toseland
The review by Banani, Lee, Hyman & Rosen (NRMCB 2017) www.nature.com/articles/nrm... on biomolecular condensates has >6000 citations. It…
1. Introduced a broad definition of “biomolecular condensates,” promoting acceptance that a unifying mechanism may underlie all membrane-less compartments.
1. Introduced a broad definition of “biomolecular condensates,” promoting acceptance that a unifying mechanism may underlie all membrane-less compartments.
Biomolecular condensates: organizers of cellular biochemistry - Nature Reviews Molecular Cell Biology
In addition to membrane-bound organelles, eukaryotic cells feature various membraneless compartments, including the centrosome, the nucleolus and various granules. Many of these compartments form thro...
www.nature.com
November 17, 2025 at 7:24 AM
The review by Banani, Lee, Hyman & Rosen (NRMCB 2017) www.nature.com/articles/nrm... on biomolecular condensates has >6000 citations. It…
1. Introduced a broad definition of “biomolecular condensates,” promoting acceptance that a unifying mechanism may underlie all membrane-less compartments.
1. Introduced a broad definition of “biomolecular condensates,” promoting acceptance that a unifying mechanism may underlie all membrane-less compartments.
Reposted by Chris Toseland
🚨Reposts appreciated‼️If I had read this PhD offer five years ago, I wouldn’t have hesitated for a second to apply 😉
Passionate about gene regulation, chromatin, and developmental biology? Just contact @radaiglesiaslab.bsky.social at @ibbtec.bsky.social 🧬✨
#PhD #3DGenome
Passionate about gene regulation, chromatin, and developmental biology? Just contact @radaiglesiaslab.bsky.social at @ibbtec.bsky.social 🧬✨
#PhD #3DGenome
November 15, 2025 at 9:53 AM
🚨Reposts appreciated‼️If I had read this PhD offer five years ago, I wouldn’t have hesitated for a second to apply 😉
Passionate about gene regulation, chromatin, and developmental biology? Just contact @radaiglesiaslab.bsky.social at @ibbtec.bsky.social 🧬✨
#PhD #3DGenome
Passionate about gene regulation, chromatin, and developmental biology? Just contact @radaiglesiaslab.bsky.social at @ibbtec.bsky.social 🧬✨
#PhD #3DGenome
In this work we show that you don’t have to target the main players in disease….instead you identify and target what they depend on!
We are very happy to share our new PrePrint: Myosin VI orchestrates estrogen-driven gene expression in breast
cancer cells. www.biorxiv.org/content/10.1...
We characterise how Myosin VI is a key regulator of the Estrogen Receptor. Perturbation of Myosin VI impedes ER functionality.
cancer cells. www.biorxiv.org/content/10.1...
We characterise how Myosin VI is a key regulator of the Estrogen Receptor. Perturbation of Myosin VI impedes ER functionality.
November 15, 2025 at 10:31 AM
In this work we show that you don’t have to target the main players in disease….instead you identify and target what they depend on!
Reposted by Chris Toseland
We're still accepting submissions for our 'Cell Biology of the Nucleus' special issue, which is being guest edited by
@abbybuch.bsky.social and Megan King (@luskinglab.bsky.social).
Submission deadline: 5 January
journals.biologists.com/jcs/pages/nu...
#nucleus #notforprofit #freetopublish
@abbybuch.bsky.social and Megan King (@luskinglab.bsky.social).
Submission deadline: 5 January
journals.biologists.com/jcs/pages/nu...
#nucleus #notforprofit #freetopublish
November 13, 2025 at 5:13 PM
We're still accepting submissions for our 'Cell Biology of the Nucleus' special issue, which is being guest edited by
@abbybuch.bsky.social and Megan King (@luskinglab.bsky.social).
Submission deadline: 5 January
journals.biologists.com/jcs/pages/nu...
#nucleus #notforprofit #freetopublish
@abbybuch.bsky.social and Megan King (@luskinglab.bsky.social).
Submission deadline: 5 January
journals.biologists.com/jcs/pages/nu...
#nucleus #notforprofit #freetopublish
Reposted by Chris Toseland
Myosin VI orchestrates estrogen-driven gene expression in breast cancer cells. https://www.biorxiv.org/content/10.1101/2025.11.13.688007v1
November 14, 2025 at 3:48 AM
Myosin VI orchestrates estrogen-driven gene expression in breast cancer cells. https://www.biorxiv.org/content/10.1101/2025.11.13.688007v1
We are very happy to share our new PrePrint: Myosin VI orchestrates estrogen-driven gene expression in breast
cancer cells. www.biorxiv.org/content/10.1...
We characterise how Myosin VI is a key regulator of the Estrogen Receptor. Perturbation of Myosin VI impedes ER functionality.
cancer cells. www.biorxiv.org/content/10.1...
We characterise how Myosin VI is a key regulator of the Estrogen Receptor. Perturbation of Myosin VI impedes ER functionality.
November 14, 2025 at 9:33 AM
We are very happy to share our new PrePrint: Myosin VI orchestrates estrogen-driven gene expression in breast
cancer cells. www.biorxiv.org/content/10.1...
We characterise how Myosin VI is a key regulator of the Estrogen Receptor. Perturbation of Myosin VI impedes ER functionality.
cancer cells. www.biorxiv.org/content/10.1...
We characterise how Myosin VI is a key regulator of the Estrogen Receptor. Perturbation of Myosin VI impedes ER functionality.
Reposted by Chris Toseland
A PhD position is available in the lab of @zech-lab.bsky.social co-supervised @christoseland.bsky.social
An exciting project to understand cellular ageing in health and disease www.findaphd.com/phds/project...
#CellBio #SuperResolutionMicroscopy
#MolecularBio #AgeingResearch #PhDOpportunity
An exciting project to understand cellular ageing in health and disease www.findaphd.com/phds/project...
#CellBio #SuperResolutionMicroscopy
#MolecularBio #AgeingResearch #PhDOpportunity
MRC DiMeN Doctoral Training Partnership: Stopping premature ageing: Investigating the role of actomyosin mediated nuclear force feedback in cell homeostasis at University of Liverpool on FindAPhD.com
PhD Project - MRC DiMeN Doctoral Training Partnership: Stopping premature ageing: Investigating the role of actomyosin mediated nuclear force feedback in cell homeostasis at University of Liverpool, l...
www.findaphd.com
November 13, 2025 at 10:25 AM
A PhD position is available in the lab of @zech-lab.bsky.social co-supervised @christoseland.bsky.social
An exciting project to understand cellular ageing in health and disease www.findaphd.com/phds/project...
#CellBio #SuperResolutionMicroscopy
#MolecularBio #AgeingResearch #PhDOpportunity
An exciting project to understand cellular ageing in health and disease www.findaphd.com/phds/project...
#CellBio #SuperResolutionMicroscopy
#MolecularBio #AgeingResearch #PhDOpportunity
Reposted by Chris Toseland
🔬Want to develop a blood test for dementia? A fully funded PhD position is available in our lab to probe and detect single molecules! Join our team @york.ac.uk
! Find out more & apply by 4th Dec:
tinyurl.com/yt36p9tx
@ybri-uoy.bsky.social @ei-science.bsky.social @timcraggs.bsky.social
! Find out more & apply by 4th Dec:
tinyurl.com/yt36p9tx
@ybri-uoy.bsky.social @ei-science.bsky.social @timcraggs.bsky.social
October 31, 2025 at 4:14 PM
🔬Want to develop a blood test for dementia? A fully funded PhD position is available in our lab to probe and detect single molecules! Join our team @york.ac.uk
! Find out more & apply by 4th Dec:
tinyurl.com/yt36p9tx
@ybri-uoy.bsky.social @ei-science.bsky.social @timcraggs.bsky.social
! Find out more & apply by 4th Dec:
tinyurl.com/yt36p9tx
@ybri-uoy.bsky.social @ei-science.bsky.social @timcraggs.bsky.social
Please repost - Multiple PhDs available
www.findaphd.com/phds/project...
www.findaphd.com/phds/project...
www.findaphd.com/phds/project...
www.findaphd.com/phds/project...
www.findaphd.com/phds/project...
www.findaphd.com/phds/project...
November 5, 2025 at 9:18 AM
Please repost - Multiple PhDs available
www.findaphd.com/phds/project...
www.findaphd.com/phds/project...
www.findaphd.com/phds/project...
www.findaphd.com/phds/project...
www.findaphd.com/phds/project...
www.findaphd.com/phds/project...
Please Repost!
Tobi Zach and I have an MRC DiMeN PhD position available! Come join us!
www.findaphd.com/phds/project...
Tobi Zach and I have an MRC DiMeN PhD position available! Come join us!
www.findaphd.com/phds/project...
MRC DiMeN Doctoral Training Partnership: Stopping premature ageing: Investigating the role of actomyosin mediated nuclear force feedback in cell homeostasis at University of Liverpool on FindAPhD.com
PhD Project - MRC DiMeN Doctoral Training Partnership: Stopping premature ageing: Investigating the role of actomyosin mediated nuclear force feedback in cell homeostasis at University of Liverpool, l...
www.findaphd.com
November 2, 2025 at 11:13 AM
Please Repost!
Tobi Zach and I have an MRC DiMeN PhD position available! Come join us!
www.findaphd.com/phds/project...
Tobi Zach and I have an MRC DiMeN PhD position available! Come join us!
www.findaphd.com/phds/project...
It’s Halloween so time to make the cells scream!
October 31, 2025 at 8:23 AM
It’s Halloween so time to make the cells scream!
Reposted by Chris Toseland
Excited for our next special issue and looking forward to working with Abby Buchwalter (@abbybuch.bsky.social) and Megan King (@luskinglab.bsky.social)! Working on the cell biology of the nucleus? Send your papers our way!
#notforprofit
#notforprofit
Call for papers: Cell Biology of the Nucleus
We invite you to submit your latest research to our special issue: Cell Biology of the Nucleus, guest edited by Abby Buchwalter @abbybuch.bsky.social, working alongside Megan King @luskinglab.bsky.social.
journals.biologists.com/jcs/pages/nu...
We invite you to submit your latest research to our special issue: Cell Biology of the Nucleus, guest edited by Abby Buchwalter @abbybuch.bsky.social, working alongside Megan King @luskinglab.bsky.social.
journals.biologists.com/jcs/pages/nu...
July 16, 2025 at 3:55 PM
Excited for our next special issue and looking forward to working with Abby Buchwalter (@abbybuch.bsky.social) and Megan King (@luskinglab.bsky.social)! Working on the cell biology of the nucleus? Send your papers our way!
#notforprofit
#notforprofit
Reposted by Chris Toseland
Phantastic review of SPT method and analysis. Great resource for every single molecule tracking enthusiast! Congratulations, @gebhardtlab.bsky.social
The review on live-cell SMT that I contribute to the jmolbiol.bsky.social special issue ‚Imaging of the central dogma‘ is now online as pre-proof: www.sciencedirect.com/science/arti...
July 10, 2025 at 8:18 AM
Phantastic review of SPT method and analysis. Great resource for every single molecule tracking enthusiast! Congratulations, @gebhardtlab.bsky.social
Yesterday we had the School of Medicine and Population Health PGR symposium - a fantastic range of talks and posters from our students!
We had excellent career sessions from Faith Nutter Howard David King and Amy Turner
Thanks to our ECRs who gave a useful and honest take on finishing a PhD.
We had excellent career sessions from Faith Nutter Howard David King and Amy Turner
Thanks to our ECRs who gave a useful and honest take on finishing a PhD.
July 9, 2025 at 6:54 AM
Yesterday we had the School of Medicine and Population Health PGR symposium - a fantastic range of talks and posters from our students!
We had excellent career sessions from Faith Nutter Howard David King and Amy Turner
Thanks to our ECRs who gave a useful and honest take on finishing a PhD.
We had excellent career sessions from Faith Nutter Howard David King and Amy Turner
Thanks to our ECRs who gave a useful and honest take on finishing a PhD.
Reposted by Chris Toseland
Announcing a new @embo.org Workshop on "Intracellular mechanics and organelle mechanobiology" that we are organizing with Michael Krieg and Verena Ruprecht at @icfo.eu (Barcelona) on 16-20 February, 2026. Please, repost and spread the word! 🙏 #EMBOmechanobio
meetings.embo.org/event/26-org...
meetings.embo.org/event/26-org...
Intracellular mechanics and organelle mechanobiology
Mechanobiology is an interdisciplinary field that emerges at the cross-section of biology, physics and engineering. It aims to understand how living cells, tissues and animals sense and respond to me…
meetings.embo.org
July 4, 2025 at 3:50 PM
Announcing a new @embo.org Workshop on "Intracellular mechanics and organelle mechanobiology" that we are organizing with Michael Krieg and Verena Ruprecht at @icfo.eu (Barcelona) on 16-20 February, 2026. Please, repost and spread the word! 🙏 #EMBOmechanobio
meetings.embo.org/event/26-org...
meetings.embo.org/event/26-org...
Doubling up on the measurements and toys today - so great and useful to have this kit next door to each other!
July 3, 2025 at 4:05 PM
Doubling up on the measurements and toys today - so great and useful to have this kit next door to each other!
Reposted by Chris Toseland
Postdoc positions open in my lab (Francis Crick Institute) to study
1. initiation of DNA replication.
2. chromatin replication/epigenetic inheritance.
Great for biochemists, biophysicists and cryo-EM/cryo-tomography scientists.
Deadline 3 August 2025.
crick.wd3.myworkdayjobs.com/External/job...
1. initiation of DNA replication.
2. chromatin replication/epigenetic inheritance.
Great for biochemists, biophysicists and cryo-EM/cryo-tomography scientists.
Deadline 3 August 2025.
crick.wd3.myworkdayjobs.com/External/job...
June 20, 2025 at 9:38 AM
Postdoc positions open in my lab (Francis Crick Institute) to study
1. initiation of DNA replication.
2. chromatin replication/epigenetic inheritance.
Great for biochemists, biophysicists and cryo-EM/cryo-tomography scientists.
Deadline 3 August 2025.
crick.wd3.myworkdayjobs.com/External/job...
1. initiation of DNA replication.
2. chromatin replication/epigenetic inheritance.
Great for biochemists, biophysicists and cryo-EM/cryo-tomography scientists.
Deadline 3 August 2025.
crick.wd3.myworkdayjobs.com/External/job...
Reposted by Chris Toseland
This is a piece that I and @karsten-rippe.bsky.social discussing a lot, and a topic that is very close to my heart. The editors @naturerevgenet.bsky.social gave us the stage to do so, and the final version of our review is now available under this link: rdcu.be/erP1u
A short thread follows 1/n
A short thread follows 1/n
June 19, 2025 at 4:37 PM
This is a piece that I and @karsten-rippe.bsky.social discussing a lot, and a topic that is very close to my heart. The editors @naturerevgenet.bsky.social gave us the stage to do so, and the final version of our review is now available under this link: rdcu.be/erP1u
A short thread follows 1/n
A short thread follows 1/n
Reposted by Chris Toseland
The QS World University Rankings 2026 have just been released and we’ve placed 92nd within the World Top 100! Huge congratulations and thanks to everyone in the University of Sheffield community for this achievement; from staff and students to alumni, supporters and friends around the world!
June 19, 2025 at 6:59 AM
The QS World University Rankings 2026 have just been released and we’ve placed 92nd within the World Top 100! Huge congratulations and thanks to everyone in the University of Sheffield community for this achievement; from staff and students to alumni, supporters and friends around the world!
Reposted by Chris Toseland
🚀 Manual mask annotation slowing you down?
💡 SAMJ is a new ImageJ/Fiji plugin using Segment Anything (SAM) for fast, interactive segmentation — no GPU needed, one-click install, real-time results.
🔬 Perfect for large biomedical images.
arxiv.org/abs/2506.02783
#AI #Bioimaging #ImageJ #OpenSource
💡 SAMJ is a new ImageJ/Fiji plugin using Segment Anything (SAM) for fast, interactive segmentation — no GPU needed, one-click install, real-time results.
🔬 Perfect for large biomedical images.
arxiv.org/abs/2506.02783
#AI #Bioimaging #ImageJ #OpenSource
June 17, 2025 at 8:16 AM
🚀 Manual mask annotation slowing you down?
💡 SAMJ is a new ImageJ/Fiji plugin using Segment Anything (SAM) for fast, interactive segmentation — no GPU needed, one-click install, real-time results.
🔬 Perfect for large biomedical images.
arxiv.org/abs/2506.02783
#AI #Bioimaging #ImageJ #OpenSource
💡 SAMJ is a new ImageJ/Fiji plugin using Segment Anything (SAM) for fast, interactive segmentation — no GPU needed, one-click install, real-time results.
🔬 Perfect for large biomedical images.
arxiv.org/abs/2506.02783
#AI #Bioimaging #ImageJ #OpenSource
Reposted by Chris Toseland
If heterochromatin is really a liquid-like condensate, why is it not spherical?
We investigated whether mechanical interactions between a condensate and a fiber network can explain the variety of morphologies seen in phase-separated nuclear compartments
www.biorxiv.org/content/10.1...
We investigated whether mechanical interactions between a condensate and a fiber network can explain the variety of morphologies seen in phase-separated nuclear compartments
www.biorxiv.org/content/10.1...
June 16, 2025 at 6:16 PM
If heterochromatin is really a liquid-like condensate, why is it not spherical?
We investigated whether mechanical interactions between a condensate and a fiber network can explain the variety of morphologies seen in phase-separated nuclear compartments
www.biorxiv.org/content/10.1...
We investigated whether mechanical interactions between a condensate and a fiber network can explain the variety of morphologies seen in phase-separated nuclear compartments
www.biorxiv.org/content/10.1...
Reposted by Chris Toseland
Applications are now open for the 4th edition of the “Ecole de Physique des Houches” on Fluorescence Markers for Advanced Microscopies, a WE-Heraeus seminar.
March 15th-20th 2026
Join us to learn everything you wanted to know about Fluorescent Markers for advanced microscopies.
March 15th-20th 2026
Join us to learn everything you wanted to know about Fluorescent Markers for advanced microscopies.
May 26, 2025 at 11:52 AM
Applications are now open for the 4th edition of the “Ecole de Physique des Houches” on Fluorescence Markers for Advanced Microscopies, a WE-Heraeus seminar.
March 15th-20th 2026
Join us to learn everything you wanted to know about Fluorescent Markers for advanced microscopies.
March 15th-20th 2026
Join us to learn everything you wanted to know about Fluorescent Markers for advanced microscopies.
Back in Harwell again for a late night reagent drop!
May 18, 2025 at 8:52 PM
Back in Harwell again for a late night reagent drop!
Quick visit back to Sheffield for more samples complete!
May 15, 2025 at 9:25 PM
Quick visit back to Sheffield for more samples complete!