Liaoyi Xu
@xliaoyi.bsky.social
Reposted by Liaoyi Xu
Excited to share our new preprint from the @arbelharpak.bsky.social Lab!
How do recruitment into genetic studies and study characteristics impact what we infer about the genetic bases of traits, and what are the consequences? (1/21)
www.biorxiv.org/content/10.6...
How do recruitment into genetic studies and study characteristics impact what we infer about the genetic bases of traits, and what are the consequences? (1/21)
www.biorxiv.org/content/10.6...
Representation in genetic studies affects inference about genetic architecture
Knowledge of a trait's "genetic architecture," namely the joint distribution of allele frequencies of causal variants and the direction and magnitude of their effects, is essential to understanding it...
www.biorxiv.org
January 14, 2026 at 7:07 PM
Excited to share our new preprint from the @arbelharpak.bsky.social Lab!
How do recruitment into genetic studies and study characteristics impact what we infer about the genetic bases of traits, and what are the consequences? (1/21)
www.biorxiv.org/content/10.6...
How do recruitment into genetic studies and study characteristics impact what we infer about the genetic bases of traits, and what are the consequences? (1/21)
www.biorxiv.org/content/10.6...
Reposted by Liaoyi Xu
1/13 In a new preprint, we (with @xliaoyi.bsky.social in the @arbelharpak.bsky.social lab) find that expression from the “inactivated” X (Xi) is consequential for both female-male differences in gene expression and variation among females in disease and physiology: www.biorxiv.org/content/10.1...
Escape from X inactivation drives sex differences and female trait variation
X chromosome inactivation (XCI) partially balances gene dosage between sexes, yet expression from the inactive X (Xi) is variable across genes. In this study, we investigate whether gene-level Xi expr...
www.biorxiv.org
August 6, 2025 at 2:42 AM
1/13 In a new preprint, we (with @xliaoyi.bsky.social in the @arbelharpak.bsky.social lab) find that expression from the “inactivated” X (Xi) is consequential for both female-male differences in gene expression and variation among females in disease and physiology: www.biorxiv.org/content/10.1...
Reposted by Liaoyi Xu
Led by Brieuc Lehmann, we have a paper on relatedness and ARG!
Closely related to my PROBGEN talk on Friday.
Closely related to my PROBGEN talk on Friday.
On ARGs, pedigrees, and genetic relatedness matrices https://www.biorxiv.org/content/10.1101/2025.03.03.641310v1
March 5, 2025 at 2:19 PM
Led by Brieuc Lehmann, we have a paper on relatedness and ARG!
Closely related to my PROBGEN talk on Friday.
Closely related to my PROBGEN talk on Friday.
Reposted by Liaoyi Xu
Think of a polygenic score you care about. Are direct genetic effects driving variation among people in this predictor? Or perhaps other, confounding factors? We at the @arbelharpak.bsky.social & @docedge.bsky.social Labs developed a method to tackle this question. [1/n]
A Litmus Test for Confounding in Polygenic Scores
Polygenic scores (PGSs) are being rapidly adopted for trait prediction in the clinic and beyond. PGSs are often thought of as capturing the direct genetic effect of one's genotype on their phenotype. ...
www.biorxiv.org
February 4, 2025 at 6:04 PM
Think of a polygenic score you care about. Are direct genetic effects driving variation among people in this predictor? Or perhaps other, confounding factors? We at the @arbelharpak.bsky.social & @docedge.bsky.social Labs developed a method to tackle this question. [1/n]
Reposted by Liaoyi Xu
I am excited to share the first first-author paper of my PhD describing work with Changde Cheng, Mark Kirkpatrick and @arbelharpak.bsky.social has been published at AJHG! We ask if sex-differential gene expression drives sex-differential selection in humans. (1/14)
www.cell.com/ajhg/fulltex...
www.cell.com/ajhg/fulltex...
No evidence for sex-differential transcriptomes driving genome-wide sex-differential natural selection
We assess the evidence for a genome-wide relationship between sex differences in gene
expression and sex differences in natural selection. We develop an improved model
for testing this association but...
www.cell.com
January 14, 2025 at 10:35 PM
I am excited to share the first first-author paper of my PhD describing work with Changde Cheng, Mark Kirkpatrick and @arbelharpak.bsky.social has been published at AJHG! We ask if sex-differential gene expression drives sex-differential selection in humans. (1/14)
www.cell.com/ajhg/fulltex...
www.cell.com/ajhg/fulltex...