Yadira Peña-García
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yadirapga.bsky.social
Yadira Peña-García
@yadirapga.bsky.social
PhD candidate at IU
Reposted by Yadira Peña-García
Have you ever wondered: just how strong *is* the evidence for Muller's ratchet on mtDNA?

Well, wonder no more!

(Project led by Yu Mo, with @smishra677.bsky.social and @yadirapga.bsky.social)

"No molecular evidence for Muller's ratchet in mitochondrial genomes"
www.biorxiv.org/content/10.6...
No molecular evidence for Muller's ratchet in mitochondrial genomes
Muller's ratchet predicts that non-recombining genomes can accumulate deleterious mutations, though molecular evidence for it is rare. Previous studies have tried to detect ratchet-like behavior in mi...
www.biorxiv.org
December 17, 2025 at 2:36 PM
Reposted by Yadira Peña-García
New paper led by @yadirapga.bsky.social!

Opossums have babies at 6-months of age, but are still highly male-biased in their mutations

academic.oup.com/genetics/adv...
Low mutation rate but high male-bias in the germline of a short-lived opossum
Abstract. Age and sex have been found to be important determinants of the mutation rate per generation in mammals, but the mechanisms underlying these fact
academic.oup.com
September 1, 2025 at 7:09 PM
Reposted by Yadira Peña-García
New paper led by @glom.bsky.social!

"Unprecedented female female bias in the aye-aye, a highly unusual lemur from Madagascar"

1/
journals.plos.org/plosbiology/...
February 10, 2025 at 2:50 PM
Reposted by Yadira Peña-García
New paper led by @yadirapga.bsky.social!

Even though opossums have kids at 0.5 years, they still have typical male-biased mutation (though not quite as high as humans).

"Low mutation rate but high male-bias in the germline of a short-lived opossum"

www.biorxiv.org/content/10.1...
Low mutation rate but high male-bias in the germline of a short-lived opossum
Age and sex have been found to be important determinants of the mutation rate per generation in mammals, but the mechanisms underlying these factors are still unclear. One approach to distinguishing b...
www.biorxiv.org
December 10, 2024 at 8:05 PM