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CELEBRATE: Prehospital Platelet Inhibitor Zalunfiban Hits Mark in STEMI

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Reposted by Yael L. Maxwell

TCTMD @tctmd.bsky.social · 8d

In the phase III CELEBRATE trial, the novel injectable glycoprotein IIb/IIIa inhibitor zalunfiban has met its primary safety and efficacy outcomes in STEMI patients. Read more here: www.tctmd.com/news/celebra...

The drug met primary safety and efficacy outcomes, with full results to be presented at the AHA Scientific Sessions.

Lowering Novel Biomarker, GDF-15, Raises HF Event Rate: GARDEN-TIMI 74 [email protected] Tue, 09/30/2025 - 14:33 Yael L. Maxwell Despite success in some cancer patients, a drug that neutralizes GDF-15 was clearly harmful in HF patients. The question is, why?

Yael L. Maxwell @yaelmaxwell.bsky.social · 7d

“You often learn from when science goes the opposite direction from what you expect,” said presenter David Berg, MD. The next question to answer is what role GDF-15 plays in heart failure. #HFSA2025 #CardioSky

TCTMD @tctmd.bsky.social · 8d

Lowering Novel Biomarker, GDF-15, Raises HF Event Rate: GARDEN-TIMI 74

CCM-D Delivers Safe, Effective Integrated Therapy in HFrEF [email protected] Mon, 09/29/2025 - 15:45 Yael L. Maxwell The Integra-D trial shows the device, which provides cardiac contractility modulation and defibrillation, also eases symptoms.

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Yael L. Maxwell @yaelmaxwell.bsky.social · 9d

Another from #HFSA2025: this time looking at a new CCM-D device in patients with HFrEF. Will this be enough for CCM to gain traction in the HF world? #CardioSky

TCTMD @tctmd.bsky.social · 9d

CCM-D Delivers Safe, Effective Integrated Therapy in HFrEF

Voice Analysis Picks Up Patients at Risk for HF Hospitalization: COMMUNITY-HF [email protected] Mon, 09/29/2025 - 12:17 Yael L. Maxwell Vocal monitoring has the potential to identify HF patients with worsening congestion early and prevent acute decompensation.

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Yael L. Maxwell @yaelmaxwell.bsky.social · 9d

My first from #HFSA2025 and an interesting one to boot! The Cordio HearO App can pick up signals of heart failure events more than 3 weeks before they happen. #CardioSky

TCTMD @tctmd.bsky.social · 9d

Voice Analysis Picks Up Patients at Risk for HF Hospitalization: COMMUNITY-HF

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Yael L. Maxwell @yaelmaxwell.bsky.social · 11d

The first plenary session at #HFSA2025 is about to begin and all of my coverage will be on ⁦‪@tctmd.bsky.social!‬⁩ Who else is here and what are you looking forward to at the meeting?

Reposted by Yael L. Maxwell

TCTMD @tctmd.bsky.social · 14d

What's new in the world of cardiology? In this month's Heart Sounds, the TCTMD team highlights their favorite stories from September, and @DrRobRoswell joins to discuss DAPT-SHOCK-AMI. Full episode here: www.tctmd.com/audio/top-ca...

@yaelmaxwell.bsky.social

ESC/EACTS Release New Valvular Heart Disease Guidelines

Yael L. Maxwell @yaelmaxwell.bsky.social · Sep 3

Earlier, less invasive treatment is the name of the game according to new @escardio.bsky.social and @eacts.bsky.social valvular heart disease guidelines. #ESCongress

www.tctmd.com/news/esceact...

Among the changes are a lower TAVI age cutoff and greater emphasis on patient education and coronary CTA.

Reposted by Yael L. Maxwell

TCTMD @tctmd.bsky.social · Aug 18

On the latest On Record, @yaelmaxwell.bsky.social, Gilbert Tang, and Tsuyoshi Kaneko discuss reinterventions after TAVI during #NYValves2025. Watch the full video here: www.tctmd.com/videos/on-re...

New ACC/AHA Hypertension Guidelines Still Urge Early Treatment but With Some Twists

Yael L. Maxwell @yaelmaxwell.bsky.social · Aug 14

New US hypertension guidelines, the first since 2017, released today reinforce prior recs that prioritize lowering BP early and aggressively, with special emphasis on lifestyle, the connection between BP and cognitive function, and pregnancy. #CardioSky

www.tctmd.com/news/new-acc...

The document, last updated in 2017, promotes use of the PREVENT calculator as well as more flexible BP goals.

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Reposted by Yael L. Maxwell

TCTMD @tctmd.bsky.social · Aug 7

During #NYValves2025, Patrick O'Gara, Michael Borger, and @yaelmaxwell.bsky.social discussed how the FDA approval of asymptomatic TAVI has changed practice, with perspectives from the US and Europe. Watch the full episode of On Record here: www.tctmd.com/videos/on-re...

Reposted by Yael L. Maxwell

TCTMD @tctmd.bsky.social · Jul 31

In this episode of Heart Sounds, our TCTMD journalists discuss the top news in cardiology for July. @lamckeown1.bsky.social @yaelmaxwell.bsky.social @toddneale.bsky.social www.tctmd.com/audio/top-ca...

Yael L. Maxwell @yaelmaxwell.bsky.social · Jul 31

I set up a Signal account if anyone would prefer to reach me there.

Cardiologists More Often Send Higher-Risk Patients for CAC Scans vs Generalists

Yael L. Maxwell @yaelmaxwell.bsky.social · Jul 30

Whether a patient undergoes CAC screening depends on the type of doctor they see, with large sex differences observed over the past decade at a single healthcare system, according to retrospective data. #SCCT2025 #CardioSky

www.tctmd.com/news/cardiol...

The decade-long, single-healthcare-system study gives insights into how physicians are using CAC tests and in which patients.

Less Plaque With Intensive Medical Therapy vs Usual Care in INOCA: WARRIOR

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Yael L. Maxwell @yaelmaxwell.bsky.social · Jul 29

Intensive medical therapy usual care for reducing noncalcified coronary plaque in women who have INOCA, according to results of a serial imaging subanalysis of the WARRIOR trial. #SCCT2025 #CardioSky @damini-d.bsky.social

www.tctmd.com/news/less-pl...

The serial imaging substudy shows that intensive therapy might change plaque morphology positively, researchers say.

Defining Success in Medicine

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Yael L. Maxwell @yaelmaxwell.bsky.social · Jul 25

New in the @tctmd.bsky.social Fellows in Focus Feed: Attendees at #Fellows2025 tell us how they define success in medicine. #FellowsForum #CardioSKy

www.tctmd.com/videos/defin... @abdullahalabcha.bsky.social

From patient satisfaction to making family and mentors proud, fellows tell TCTMD they feel fulfilled in a variety of ways.

Leaders in Cardiac CT Look Back on 20 Years of Growth Despite Challenges

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Yael L. Maxwell @yaelmaxwell.bsky.social · Jul 25

Leaders in the field of cardiac CT celebrated 20 years of science, innovation, and overcoming challenges during a special session at the 2025 @scct-heart.bsky.social meeting. #SCCT2025 #CardioSky

www.tctmd.com/news/leaders...

A special session at SCCT was dedicated to the history of the field, but also explored future directions and unanswered questions.

AI-QCT Possibly Lessens Gap Between Ideal vs Actual Care for Patients at Risk of ASCVD

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Yael L. Maxwell @yaelmaxwell.bsky.social · Jul 24

AI-QCT can potentially improve preventive care for patients, especially women, thought to be at risk for ASCVD, according to an analysis of the CERTAIN study. #SCCT2025 #CardioSky

www.tctmd.com/news/ai-qct-...

The “hypothesis-generating” results show that the technology might improve use of preventive therapies, especially in women.

AI-Based Coronary Plaque Analysis Can Inform Management Beyond CCTA: DECIDE Registry

Yael L. Maxwell @yaelmaxwell.bsky.social · Jul 22

For symptomatic patients who’ve undergone CCTA, added knowledge gleaned from AI-CPA (@heartflow.bsky.social) changes the management strategy more than half the time, according to new data from the DECIDE registry.

tctmd.com/news/ai-base...
@cianpmccarthy.bsky.social #SCCT2025 #Cardiosky

The technology, which led to a shift in strategy more than half of the time, could save $719 per symptomatic patient over 10 years.

tctmd.com

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Yael L. Maxwell @yaelmaxwell.bsky.social · Jul 18

Among more than 300 young, fit firefighters, CCTA led to 3.6% undergoing a diagnostic cath and 28.6% being referred to a cardiologist for medical or lifestyle management. Among the 2/3 with 0 CAC, 83% had noncalcified plaque. #SCCT2025 #CardioSky

www.tctmd.com/news/adding-...

Adding Coronary CT Angiography to Annual Firefighter Physicals Could Save Lives

Scanning identified significant CAD in this high-risk population, even among those with zero CAC.

Carbon Footprint of Surgical AVR Double the Size of TAVI’s

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Yael L. Maxwell @yaelmaxwell.bsky.social · Jul 18

I’m excited to be in Montréal for #scct2025. Who else is here and what are you most looking forward to hearing about? (And where can I find the best poutine in town?😉)

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Yael L. Maxwell @yaelmaxwell.bsky.social · Jul 16

"It’s not so much that one therapy is better than another, but there are consequences to everything that we do," says Isaac George.

www.tctmd.com/news/carbon-... #cardiosky

The study isn’t intended to sway clinical decision-making, but to make doctors aware of the impact of their choices.

Carbon Footprint of Surgical AVR Double the Size of TAVI’s

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Yael L. Maxwell @yaelmaxwell.bsky.social · Jul 15

"It’s not so much that one therapy is better than another, but there are consequences to everything that we do," says Isaac George.

www.tctmd.com/news/carbon-... #CardioSky

The study isn’t intended to sway clinical decision-making, but to make doctors aware of the impact of their choices.

Good Outcomes, Little Hospital Experience: Pascal TEER in Real World

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Yael L. Maxwell @yaelmaxwell.bsky.social · Jun 30

TEER with the Pascal system in patients with degenerative MR results in good early survival outcomes, significant reductions in MR, and improvements in quality of life, according to an analysis of the STS/ACC TVT Registry. #NYValves2025 #CardioSky

www.tctmd.com/news/good-ou...

The study led to questions about whether patients would be best served by being treated at high-volume centers of excellence.

Long-term Survival Better With TAVI Explant vs Redo: Medicare Data

Yael L. Maxwell @yaelmaxwell.bsky.social · Jun 30

My 1st from #NYValves2025 (and my 1st time at this meeting!):

Surgical explant is associated with better long-term survival compared with redo TAVI in a population of Medicare patients requiring reintervention. @ShinFukuharaMD @DrBowdish @TsuyoshiKaneko1

www.tctmd.com/news/long-te...

The procedures are not mutually exclusive, however, and should be considered on a patient-by-patient basis, a researcher says.