The Yale Medicine Distinguished Clinical Career Award honors physicians who have contributed to Yale Medicine for at least 20 years since completing their

Cancer researchers focused on improving the success of cancer immunotherapies introduced a new tool in a Yale study published Sept. 29 in Nature Chemical

npj Breast Cancer - Association of potential biomarkers with clinical outcomes in metastatic triple-negative breast cancer treated with pembrolizumab or chemotherapy

An analysis of opioid use and prescriptions for more than 10,000 Connecticut patients with cancer found modest decreases in both new and additional painkiller

KRAS G12C mutations in non-small cell lung cancer (NSCLC) have been associated with improved immune-checkpoint inhibition (ICI) outcomes. However, it remains unclear whether this benefit reflects alle...

Breast cancer remains the most commonly diagnosed malignancy among women worldwide. Standard treatment often involves mastectomy, followed by chemotherapy and/or radiation. Approximately 40% of patients undergo breast reconstruction to address the physical and psychological effects of tissue loss. Since the first autologous breast reconstruction described in 1887, both autologous and alloplastic techniques have evolved significantly to improve patient outcomes. However, current approaches are limited by issues such as the inability to restore biological breast function, suboptimal tissue integration, and concerns over long-term implant viability. Tissue engineering has emerged as a promising field capable of overcoming these limitations. Since the 1990s, advances in biomaterials, stem cell research, and regenerative strategies have enabled the development of vascularized, patient-specific constructs with potential applications in both structural and functional breast reconstruction. This review provides a comprehensive overview of the evolution of breast reconstruction techniques and the integration of tissue engineering into the field. Particular emphasis is placed on tissue engineering’s role in enhancing breast cancer treatment and diagnosis while also exploring future directions toward functional restoration, including lactation.

Introduction The epigenetic silencing of O 6-methylguanine DNA methyltransferase (MGMT) is associated with reduced DNA repair capacity, carcinogenesis and increased sensitivity to alkylating chemother...

Cervical cancer is one of the most prevalent and deadly cancers worldwide. Here we demonstrate the preclinical pharmacology of Dato-DXd, a TROP2-targe…