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yalembb.bsky.social
Yale MB&B
@yalembb.bsky.social
82 followers 80 following 8 posts
Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT
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Reposted by Yale MB&B
paulsenlab.bsky.social
Candie Paulsen Lab @paulsenlab.bsky.social · 6d
🧠Pain sensors need to switch on fast—and off just as quickly.

In our new tour de force Nat Comms paper - led by the first Paulsen lab grad student - we show that calmodulin plays a key role in shutting down the TRPA1 pain receptor - a finding that could guide new pain therapies.

📰 rdcu.be/eJcMK
Calmodulin binding is required for calcium mediated TRPA1 desensitization
Nature Communications - For pain signaling to be useful, sensory receptors must rapidly detect noxious stimuli and efficiently turn off once the threat has passed. Here, the authors uncover a...
rdcu.be
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yalembb.bsky.social
Yale MB&B @yalembb.bsky.social · 17d
Thank you to everyone who attended this year’s retreat at the Heritage Hotel. A special thank you to retreat coordinators Enrique De La Cruz, Rachel Agosto, and Liz Vellali!
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yalembb.bsky.social
Yale MB&B @yalembb.bsky.social · 24d
Malvankar lab publishes pioneer research delving into the quantum mechanics underlying bacterial respiration

mbb.yale.edu/news/malvank...
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yalembb.bsky.social
Yale MB&B @yalembb.bsky.social · Aug 20
Ailong Ke Leads Study Revealing Hidden RNA‑Editing Activity in CRISPR‑Cas9
www.cell.com/cell/fulltex...
Conversion of IscB and Cas9 into RNA-guided RNA editors
An engineered RNA-guided editing platform for efficient gene knockdown and sequence correction at the mRNA level.
www.cell.com
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Reposted by Yale MB&B
jcb.org
Journal of Cell Biology @jcb.org · Aug 18
Heffler and @LammerdingLab.bsky.social discuss recent studies from the @schliekerlab.bsky.social (doi.org/10.1083/jcb....) and @hennelab.bsky.social (doi.org/10.1016/j.ce...) that identify two proteins serving as crucial mechanical elements in the endoplasmic reticulum. rupress.org/jcb/article/...
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yalembb.bsky.social
Yale MB&B @yalembb.bsky.social · Aug 18
Congratulations to Enrique M. De La Cruz for his election as President of the Biophysics Society! mbb.yale.edu/news/congrat...
Reposted by Yale MB&B
yalerna.bsky.social
Yale Center for RNA Science and Medicine @yalerna.bsky.social · Jun 2
🔬 Join us LIVE on Zoom this Wednesday, June 11, at 4 PM ET!
We’re excited to co-host the RNA Collaborative Seminar Series featuring
🎙️ Dr. @siggyn5.bsky.social (Yale RNA Center)
🎙️ Dr. Alex Wesselhoeft (HMS Initiative for RNA Medicine)

Registration 👉 lnkd.in/e-9Huhzd
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Reposted by Yale MB&B
yalerna.bsky.social
Yale Center for RNA Science and Medicine @yalerna.bsky.social · Jun 5
🧬 June RNA Club at Yale

📅 Tuesday, June 10th, 2025
📍 Location: Bass Center 305, Yale Science Building (Science Hill)

This month’s speakers:
🔹 Dr. Chengtao Xu (Ke Lab)
🔹 Dr. Jyotsna Kumar (Garg Lab)

📣 Come for the science—stay for the conversations!
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Reposted by Yale MB&B
schliekerlab.bsky.social
Christian Schlieker @schliekerlab.bsky.social · Jun 9
We’ve pioneered a disease-agnostic screening platform for aberrant biomolecular condensates—cellular structures linked to incurable neurological diseases. We screened genes and FDA-approved drugs that modulate disease-relevant nuclear condensates: www.biorxiv.org/cgi/content/...
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yalembb.bsky.social
Yale MB&B @yalembb.bsky.social · Jun 9
Join us next week for MB&B's Computational Biophysics & Biochemistry Symposium on 6/17 in Bass 305!
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Reposted by Yale MB&B
schliekerlab.bsky.social
Christian Schlieker @schliekerlab.bsky.social · May 19
we are beyond proud that our @yalembb.bsky.social @schliekerlab.bsky.social undergraduate researcher Sophia graduated as the sole @Yale Colleague '25 graduate with an exceptional distinction in the major! Congrats Sophia for this richly deserved honor!
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yalembb.bsky.social
Yale MB&B @yalembb.bsky.social · Apr 4
Join our department as a Lecturer!
Apply here: apply.interfolio.com/163609.
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Reposted by Yale MB&B
jeremymberg.bsky.social
Jeremy Berg @jeremymberg.bsky.social · Feb 10
A useful tool and a great thing to do...

5calls.org/issue/nih-ns...
Save NIH and NSF Research Funding ⭑ 5 Calls
On February 7, the Trump administration moved to cut billions of dollars in funding from the National Institutes of Health (NIH) and National Science …
5calls.org
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yalembb.bsky.social
Yale MB&B @yalembb.bsky.social · Feb 11
📣 New work from MB&B graduate student Max Paul, published in PNAS, reveals how a conserved region of the RasGAP C2 domain enhances enzymatic activity via allosteric interaction with Ras. Structural & functional data suggest a key role in Ras regulation! 🧫🔬 mbb.yale.edu/news/mbb-gra...
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yalembb.bsky.social
Yale MB&B @yalembb.bsky.social · Feb 10
We are excited to announce a tenure-track or tenured faculty position in Computational Biophysics and Biochemistry, exploring the intricate molecular and cellular processes and the complex interactions of their macromolecular components. Join us in MB&B!

Apply now at apply.interfolio.com/162132
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